High intensity interval training increases daily life physical activity and quality of life in patients with moderate and severe asthma

Silva, Ronaldo Aparecido da; Rocco, Patrícia Gonçalves Leite; Mazzucatto, Flávio; Cukier, Alberto; Stelmach, Rafaël; Martins, Mílton A.; Carvalho, Celso Ricardo Fernandes

doi:10.1183/13993003.congress-2016.pa1338

Cited by 2 publications

(1 citation statement)

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“…We did not show any significant differences at baseline between groups in HRQoL. The observation that patients in the HIIT group had improvements in their physical, vitality, emotional, physical, and mental component scores is consistent with a study by Wisløff et al (21) who showed the positive effect of HIIT on HRQoL in patients with congestive heart failure, in COPD patients (38), and in patients with moderate and severe asthma (39). However, an 8-wk home-based exercise program did not result in significantly greater improvements in terms of QoL assessed by Pulmonary Embolism Quality of Life questionnaire and the EuroQol-5 Dimensions-3 Levels questionnaire in acute PE patients (14).…”

Section: Discussionsupporting

confidence: 91%

High-Intensity Interval Training in Patients with Pulmonary Embolism: A Randomized Controlled Trial

Jenab

Soori

Choobineh

et al. 2021

Medicine &Amp; Science in Sports &Amp; Exercise

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PurposeHigh-intensity interval training (HIIT) appears to be safe and effective in cardiovascular diseases. However, there is a paucity of data on the effect of HIIT for patients with acute pulmonary embolism (PE). The present randomized controlled trial (RCT) therefore examined the efficiency and safety of HIIT in patients with acute PE.MethodsIn single-center parallel open-label RCT, 24 patients (5 women) discharged recently with a diagnosis of intermediate–high-risk acute PE were randomized (1:1) to supervised HIIT (n = 12) or control (n = 12) group. The primary outcomes were exercise capacity evaluated in terms of the estimated maximal oxygen uptake (eV˙O2max), lung function (forced expiratory volume in 1 s [FEV1]), right ventricular (RV) function (RV/left ventricular diameter [LV] ratio), and health-related quality of life (HRQoL). Safety was the secondary outcome.ResultsEight weeks of HIIT improved eV˙O2max (+65%, P < 0.001), FEV1 (%) (+17%, P = 0.031), and RV/LV ratio diameter (−27%, P = 0.005), as well as HRQoL. All patients in the HIIT group tolerated exercise training without serious adverse events. The control group did not improve (P > 0.05) eV˙O2max, RV/LV ratio diameter, or HRQoL; however, FEV1 (%) was slightly reduced (−6%, P = 0.030).ConclusionsThe present RCT of a tailored center-based HIIT intervention provides preliminary evidence that this intervention could improve exercise capacity, lung function, RV function, and HRQoL without serious adverse events, which could provide marked clinical benefits after PE. Further larger multicenter randomized controlled studies are needed to confirm these promising findings.

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Section: Discussionsupporting

confidence: 91%