High-Grade Trichoblastic Carcinoma Arising in Trichoblastoma

Schulz, Tilman; Proske, Sylvia; Hartschuh, Wolfgang; Kurzen, Hjalmar; Paul, Eberhard; Wünsch, Peter H.

doi:10.1097/01.dad.0000142240.93956.cb

Cited by 63 publications

(14 citation statements)

References 9 publications

(11 reference statements)

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“…The alternative available treatment was thallium acetate, which could induce nephritis and paralysis. Population studies have shown that patients who received depilatory radiotherapy for ringworm during childhood have a significantly higher risk of developing tumors, particularly in the cephalic area [4,5,6, 12]. Different types of cutaneous and noncutaneous cancers, especially brain, parotid and thyroid tumors [13, 14], have been described.…”

Section: Discussionmentioning

confidence: 99%

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Low-Dose X-Ray Depilatory Treatment Induces Trichoblastic Tumors of the Scalp

Fazaa¹,

Cribier

Zarâa³

et al. 2007

Dermatology

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Background: Depilatory radiotherapy for ringworm was largely used before antifungals were available. Patients who underwent this treatment are at high risk of developing scalp tumors or other cancers. The aim of this study was to characterize scalp tumors occurring after X-ray therapy for ringworm. Methods: We included cases of postradiotherapy scalp tumors recorded at the Dermatology Department of the Charles Nicolle Hospital, Tunis between 1988 and 2001. We recorded clinical descriptions and all cases were resubmitted to microscopic analysis. Results: Sixty-one tumors occurred in 33 men and 12 women with a mean age of 49.8 years. Radiodermatitis was present in 21% of patients. Tumors were basal cell carcinomas in 47 cases, trichoblastomas in 10 cases and trichoblastic carcinomas in 4 cases. Twelve patients had 2–5 tumors, with combinations of tumor types in 3 of them. Mean delay of onset of tumors after radiotherapy was 39.4 years in basal cell carcinoma cases, 38.3 years in trichoblastoma cases and 35.6 years in trichoblastic carcinoma cases. Conclusions: This series shows that although basal cell carcinoma is the most frequent tumor in this situation, trichoblastomas are common. We describe, for the first time, radio-induced trichoblastic carcinomas. Trichoblastic tumors have not yet been described in this context because this concept is relatively recent.

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Section: Discussionmentioning

confidence: 99%

“…Until now, it has not been described after X-ray radiation. It is characterized by a propensity for local recurrence and potential metastatic spread [10,11,12]. This behavior differs substantially from TB or BCC.…”

Section: Discussionmentioning

confidence: 99%

Low-Dose X-Ray Depilatory Treatment Induces Trichoblastic Tumors of the Scalp

Fazaa¹,

Cribier

Zarâa³

et al. 2007

Dermatology

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“…[16][17][18] BCC is the most common malignancy worldwide in white people 19 and accounts for 65-75% of all skin tumors. 20 It originates from pluripotential primordial germ cells and founds in basal layer of epidermis and cutaneous appandages resembling the structure of hair follicle morphologically.…”

Section: Introductionmentioning

confidence: 99%

Histopathological Characteristics may not be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appandages Originating from Hair Follicle

Şengül¹

2011

UHOD

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Differential diagnosis between benign tumors of cutaneous appandages originating from hair follicle (BTCOHF) (trichoadenoma [TA], trichofolliculoma [TF], trichoepithelioma [TE] and trichoblastoma [TB]) and basal cell carcinoma (BCC) have been tedious for the pathologists, especially in the presence of small specimens to date. Thirty cases of BTCOHF and 30 cases of BCC were retrieved from the archives, deposited from 2004 to 2008. Age, sex, localisation and histopathological characters such as ulceration, pigmentation, inflammation, and cyst formation were comparatively evaluated between both groups and each subgroups. No significant diference was detetected between two groups in the rate of the age, sex and the histopathology. Besides, histopathological characters were not significant for the subgroups of BCC. However, ulceration was observed in TE (Of 21 cases 5, [23.8%]) and TB (All the 5 cases, [100%]), but not in TA and TF which are the subgroups of BTCOHF and the difference was significant (p= 0,005). But, pigmentation, inflammation and cyst formation were not significant among the subgroups of both groups. We can conclude that BCC and BTCOHF may not be discriminated concerning age, sex and histopathological characters including ulceration, pigmentation, inflammation, and cyst formation. Secondly, one may not make the differential diagnosis easily even between the subgroups of each group via evaluating the histopathological characters, so that might create some life-threatening unwelcome outcomes. Keywords: Basal cell carcinoma, Pigmentation, Inflammation, Histopathology ÖZET Histopatolojik karakterler Bazal Hücreli Karsinoma ile K›l Follikülünden Köken Alan Benign Deri Eki Tümörlerinin Ay›r›c› Tan›s›nda Yararl› OlamayabilirTrikoadenoma, trikofolliküloma, trikoepitelyoma ve trikoblastoman›n bazal hücreli karsinomadan ay›r›c› tan›s›, bugüne kadar özellikle küçük spesimenlerde patologlar için can s›k›c› ve usand›r›c› olmaya devam edegelmifltir. Otuz k›l follikülünden köken alan benign deri eki tümörleri olgusu ve 30 bazal hücreli karsinoma olgusu, 2004 -2008 y›llar› aras›nda depoland›¤› arflivden yeniden edinildi. Yafl, cinsiyet, lokalizasyon ve ülserasyon, pigmentasyon, inflamasyon ve kist formasyonu gibi histopatolojik karekterler her iki grup ve her subgrup aras›nda karfl›laflt›rmal› olarak de¤erlendirildi. Yafl, cinsiyet, lokalizasyon ve histopatoloji aç›s›ndan iki grup aras›nda anlaml› fark saptanmad›. Ayr›ca, histopatolojik karekterler bazal hücreli karsinoman›n subgruplar› için anlaml› de¤ildi. Bununla birlikte; ülse-rasyon, k›l follikülünden köken alan benign deri eki tümörlerinin subgruplar› olan trikoepitelyoma (21 olgunun 5'inde [%23.8]) ve trikoblastomada (5 olgunun tümünde [%100]) izlendi, ancak trikoadenoma ve trikofollikülomada izlenmedi ve bu fark anlaml› bulundu (p= 0.005). Pigmentasyon, inflamasyon ve kist formasyonu her iki grubun subgruplar› aras›nda anlaml› de¤ildi.

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“…malignant mixed tumour, microcycstic adnexal carcinoma), that have been well established as entities up to now [3]. A partly malignant transformation of DT seems to be rare, but possible, in cases of multiple familial trichoepithelioma (Brooke–Spiegler syndrome) [4–6]. Malignant transformation of the complete DT has not yet been described.…”

Section: Introductionmentioning

confidence: 99%

Microcystic adnexal carcinoma of the upper lip misdiagnosed benign desmoplastic trichoepithelioma

Rustemeyer

Zwerger

Pörksen

et al. 2012

Oral Maxillofac Surg

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BackgroundDesmoplastic trichoepithelioma (DT) is a benign appendageal tumour predominately localized on the facial skin. The histological diagnosis can be difficult in some cases. Partial malignant transformation of a DT is a rarity and a complete transformation has never been described in literature.Case reportA DT of the upper lip was diagnosed histologically by a small biopsy 4 years previously. At presentation, the tumour had enlarged and had partly infiltrated the left side of the upper lip and subnasal region. Histological evaluation confirmed a microcystic adnexal carcinoma but without evidence of malignant transformation of the DT. It appeared that a too-small initial biopsy had led to the incorrect histological diagnosis of a benign tumour. Thus, it was necessary to perform a tumour resection and reconstruction using a two-flap technique including a rotation flap and an Abbé flap. Functional and aesthetic outcomes were good after 6 months. There were no recurrences during a 12-month follow-up.ConclusionA facial DT should be resected completely. Patients should be attended for follow-ups, keeping in mind the difficulty of making a proper histological diagnosis from small biopsies or excisions and the consequences of ablative facial surgery. However, in particular cases, subtotal defects of the upper lip region are amenable to reconstruction without gross functional or aesthetic deficits.

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High-Grade Trichoblastic Carcinoma Arising in Trichoblastoma

Cited by 63 publications

References 9 publications

Low-Dose X-Ray Depilatory Treatment Induces Trichoblastic Tumors of the Scalp

Low-Dose X-Ray Depilatory Treatment Induces Trichoblastic Tumors of the Scalp

Histopathological Characteristics may not be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appandages Originating from Hair Follicle

Microcystic adnexal carcinoma of the upper lip misdiagnosed benign desmoplastic trichoepithelioma

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