2015
DOI: 10.1080/21623945.2015.1061723
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High-fat diet-induced obesity Rat model: a comparison between Wistar and Sprague-Dawley Rat

Abstract: In the past decades, obesity and associated metabolic complications have reached epidemic proportions. For the study of these pathologies, a number of animal models have been developed. However, a direct comparison between Wistar and Sprague-Dawley (SD) Rat as models of high-fat (HF) diet-induced obesity has not been adequately evaluated so far. Wistar and SD rats were assigned for 2 experimental groups for 17 weeks: standard (St) and high-fat (HF) diet groups. To assess some of the features of the metabolic s… Show more

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Cited by 253 publications
(228 citation statements)
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References 46 publications
(37 reference statements)
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“…Another study showed that long-term consumption of diets rich in carbohydrates can increase the abundance of Prevotella 43. In addition, a study showed that Prevotella decreased in rats fed a high fat diet44.…”
Section: Discussionmentioning
confidence: 99%
“…Another study showed that long-term consumption of diets rich in carbohydrates can increase the abundance of Prevotella 43. In addition, a study showed that Prevotella decreased in rats fed a high fat diet44.…”
Section: Discussionmentioning
confidence: 99%
“…Hal ini sesuai dengan penelitian yang dilakukan Nikasa et al (2016) yang menunjukkan bahwa diet tinggi kolesterol secara signifikan meningkatkan bobot badan tikus. Beberapa penelitian serupa menunjukkan bahwa tikus yang diberikan pakan tinggi lemak bobot badannya akan meningkat secara signifikan (Davidson et al 2010;Chien et al 2016;Marques et al 2016). Pada minggu ketiga dan keempat mulai diberikan intervensi berdasarkan kelompok perlakuan.…”
Section: Perubahan Bobot Tikusunclassified
“…However, obesity may produce a fail on adiponectin signaling (resistance of diponectin). However, Marques et al [16] showed that adiponectin plays a role in the decrease of insulin sensitivity happened by HFD and illustrated that hyperglycemia initiated by the HFD was associated with linked by a decrease in gene expression of adiponectin in the adipose tissue while did not cause a reduction in the serum levels of adiponectin, speculating that there is a compensative influence of the other depots of fat on serum levels of adiponectin. Previously, it El-Baz et al…”
Section: Discussionmentioning
confidence: 99%