Therapeutic Impact of Berries (Morus Alba and Morus Rubra) Fruit Extract in the Regression of High-Fat Diet-Induced Cardiac Dysfunction in Rats

Baz, Farouk K. El; Aly, Hanan F.; Abd‐Alla, Howaida I.; Biomy, Dalia F

doi:10.22159/ajpcr.2018.v11i7.25859

Cited by 6 publications

(5 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings showed the capacity of M. alba fruit to manage hyperlipidaemia. In another study, M. alba fruit modulated obesity-induced cardiac dysfunction by inhibiting lipogenesis and fibrosis, and enhancing lipolysis in high-fat diet-induced obesity [ 74 ]. Fruit extract also attenuated reactive oxygen species (ROS), vascular function, inflammatory markers, and lipid accumulation while reducing collagen in obese rats; these are considered factors for defense against and remediation of obesity-related cardiac dysfunction cardiac fibrosis.…”

Section: Nutraceutical Properties Of Morus Albamentioning

confidence: 99%

Morus alba L. Plant: Bioactive Compounds and Potential as a Functional Food Ingredient

Chen

Razali

Saikim

et al. 2021

Foods

View full text Add to dashboard Cite

Morus alba L. (M. alba) is a highly adaptable plant that is extensively incorporated in many traditional and Ayurveda medications. Various parts of the plant, such as leaves, fruits, and seeds, possess nutritional and medicinal value. M. alba has abundant phytochemicals, including phenolic acids, flavonoids, flavonols, anthocyanins, macronutrients, vitamins, minerals, and volatile aromatic compounds, indicating its excellent pharmacological abilities. M. alba also contains high nutraceutical values for protein, carbohydrates, fiber, organic acids, vitamins, and minerals, as well as a low lipid value. However, despite its excellent biological properties and nutritional value, M. alba has not been fully considered as a potential functional food ingredient. Therefore, this review reports on the nutrients and bioactive compounds available in M. alba leaves, fruit, and seeds; its nutraceutical properties, functional properties as an ingredient in foodstuffs, and a microencapsulation technique to enhance polyphenol stability. Finally, as scaling up to a bigger production plant is needed to accommodate industrial demand, the study and limitation on an M. alba upscaling process is reviewed.

show abstract

Section: Nutraceutical Properties Of Morus Albamentioning

confidence: 99%

Morus alba L. Plant: Bioactive Compounds and Potential as a Functional Food Ingredient

Chen

Razali

Saikim

et al. 2021

Foods

View full text Add to dashboard Cite

show abstract

“…In this type, the dispersion system is formed by drug incorporation into crystalline carriers such as urea and sugars, creating a slowly releasing thermodynamically stable crystalline SD. [14][15][16] The eutectic mixture was the first SD to be formulated. The monotectic mixture is not favored since the product and carrier melting points are unaffected.…”

Section: First-generation Solid Dispersionmentioning

confidence: 99%

“…The proposed carriers such as Hydroxy Propyl Cellulose (HPC) and Eudragit RS are used to sustain the release of biologically short half-life drugs. 14,25 Solubility enhancement and extending the drug release in a controlled manner are the main targets of the CSRD. 25…”

Section: Fourth-generation Solid Dispersionmentioning

confidence: 99%

Solid Dispersion as a Technical Solution to Boost the Dissolution Rate and Bioavailability of Poorly Water-Soluble Drugs

Attia¹,

Hasan²,

Ghazy³

et al. 2021

IJPER

View full text Add to dashboard Cite

Solid dispersion (SD) is one of the oldest and widely utilized techniques to improve the solubility of slowly dissolving drugs. A variety of pharmaceutically compatible additives using different emerging technology is used for preparing SDs. Multiple approaches were designed to prepare SDs by such as kneading, co-milling, fusion, solvent evaporation and various solvent-associated methods. The selection of appropriate preparation method and carrier is vital for producing a homogenous product affecting its stability and biological activity. Many attempts were recently carried out to improve the scalability of the applied approaches and the results were novel preparation methods such as KinetiSol, Electrospinning and Hot-melt extrusion. In the present review, drug carriers used to formulate SD were classified as small molecular weight carriers, large molecular weight named polymeric carriers and functionalized polymeric ones. Moreover, new attractive SD formulated using the newly emerged natural carriers recently joined the field of the pharmaceutical industry.

show abstract

“…Fruits of mulberry (Morus alba L. and Morus rubra L.) are rich in polyphenolic compounds such as quercetin, rutin, and 1-deoxynojirimycin. El-Baz et al (2018a) have studied the potential of fruit extract from Morus alba L. and Morus rubra L. to attenuate obesity-induced cardiac dysfunction and fibrosis in rats. Their histopathological experiments have shown that oral administration of the extracts to the obese rats has significantly treated cardiac dysfunction and fibrosis linked to obesity.…”

Section: Polyphenolsmentioning

confidence: 99%

Plant Products and Their Inhibitory Activity Against Pancreatic Lipase

Bajes

Almasri

Bustanji

2020

Rev. Bras. Farmacogn.

View full text Add to dashboard Cite

Imbalance in metabolism can lead to many health complications, and obesity is one of the alarming ones in the new world. Modern lifestyle has reduced physical activity and increased intake of various processed, unhealthy, fattening, and fast food. Many approaches have been followed to reduce lipid absorption through the gastrointestinal tract, including herbal plants and drugs. However, due to the side effects associated with drugs, more researches have been navigating towards the discovery of natural substances to substitute synthetic ones. Natural substances have been isolated and identified to inhibit pancreatic lipase, a key enzyme of lipid metabolism; however, only a few have been tested in clinical studies. The aim of this review is to provide relevant information on natural substances derived from plants and algae that have the potential to be anti-obesity agents, with attention to some medicinal plants from Jordan. As a consequence of the information presented in this mini review, several natural compounds have demonstrated to reduce lipid metabolism and absorption, which makes them potential anti-obesity agents.

show abstract

Therapeutic Impact of Berries (Morus Alba and Morus Rubra) Fruit Extract in the Regression of High-Fat Diet-Induced Cardiac Dysfunction in Rats

Cited by 6 publications

References 34 publications

Morus alba L. Plant: Bioactive Compounds and Potential as a Functional Food Ingredient

Morus alba L. Plant: Bioactive Compounds and Potential as a Functional Food Ingredient

Solid Dispersion as a Technical Solution to Boost the Dissolution Rate and Bioavailability of Poorly Water-Soluble Drugs

Plant Products and Their Inhibitory Activity Against Pancreatic Lipase

Contact Info

Product

Resources

About