Plant Products and Their Inhibitory Activity Against Pancreatic Lipase

Abstract

Imbalance in metabolism can lead to many health complications, and obesity is one of the alarming ones in the new world. Modern lifestyle has reduced physical activity and increased intake of various processed, unhealthy, fattening, and fast food. Many approaches have been followed to reduce lipid absorption through the gastrointestinal tract, including herbal plants and drugs. However, due to the side effects associated with drugs, more researches have been navigating towards the discovery of natural substances to substitute synthetic ones. Natural substances have been isolated and identified to inhibit pancreatic lipase, a key enzyme of lipid metabolism; however, only a few have been tested in clinical studies. The aim of this review is to provide relevant information on natural substances derived from plants and algae that have the potential to be anti-obesity agents, with attention to some medicinal plants from Jordan. As a consequence of the information presented in this mini review, several natural compounds have demonstrated to reduce lipid metabolism and absorption, which makes them potential anti-obesity agents.

Potential of enhancing anti-obesogenic agriceuticals by applying sustainable fertilizers during plant cultivation

“…In the same way, carbohydrates are hydrolyzed into monosaccharides and disaccharides by enzymes including α-amylase and α-glucosidase, and a fraction of the monosaccharides are used to produce glycogen, which is then converted into fat (Rajan et al, 2020;Shang et al, 2021). Therefore, using edible and medicinal plants to inhibit digestive enzymes effectively reduces lipid and carbohydrate absorption and prevents obesity (Marrelli et al, 2018;Kamoun et al, 2019;Bajes et al, 2020). Pancreatic and gastric lipases are among the .…”

“…A protein from the Litchi chinensis seed at 100 µg/mL could also inhibit 68.2% of the pancreatic lipase activity, with an IC 50 of 73.1 µg/mL (Mhatre et al, 2019). Bajes et al (2020) described that polysaccharides (e.g., pectin) could reduce fat absorption in the gastrointestinal tract by changing the characteristics of gastrointestinal fluids, restricting pancreatic lipase activity (competitive inhibition), and affecting the fat aggregation state.…”

Design, Synthesis, Characterization, Enzyme Inhibition, Molecular Docking, and Pharmacological Evaluation of New Chalcone‐Sulfonate Derivatives Bearing Thiophene

“…Pancreatic lipase (PL) inhibition is one of the well-known treatment modalities in obesity, as PL is the main enzyme responsible for the digestion of dietary triacyl glycerides and lipid absorption through the small intestine. [39,40] Although many natural or synthetic compounds have been tested as potential PL inhibitors, [41,42] only orlistat was approved as an anti-obesity drug. [43] It is important to the development of reliable drugs to be effective in the treatment of diseases caused by obesity.…”

Pancreatic Lipase Inhibition Activity in Lipid Absorption Using Traditional Plants: A Systematic Review and Meta-Analysis

“…Next, flavonoid compounds commonly found in plants with great bioactivity potential are quercetin [20][21]. In addition to flavonoids, pancreatic lipase inhibitory phytochemicals contained in plants or isolated from plants have been reported to be saponins, polyphenols, alkaloids, carotenoids, and terpenes [22][23]. Phenolic derivatives such as chlorogenic acid, catechin, and caffeic acid have a positive correlation with pancreatic lipase inhibition [24].…”