High-Dose Versus Low-Dose Intravenous Immunoglobulin in Hypogammaglobulinaemia and Chronic Lung Disease

Allogeneic stem cell transplantation: low immunoglobulin levels associated with decreased survival

“…Patients with serum IgG values below 4 g/l were defined as significantly deficient according to the existing guidelines for antibody-replacement therapy. 29,30 Measurement of IgG Levels Serum samples for measurement of IgG levels were collected 3, 6, 9 and 12 months following hemopoietic stem cell transplantation and then at yearly intervals until 5 years posttransplantation. Serum IgG was analyzed routinely by nephelometry at Karolinska University Laboratory, Department of Clinical Chemistry.…”

Primary hypogammaglobulinemia: The impact of early diagnosis in lung complications

“…23 It is important to consider that in our study patients received doses of immunoglobulin for a few years without this individualization, maintaining IgG levels around 500 mg/dL, according to the values recommended by the literature at the time. 8 The maintenance of lower serum IgG levels may explain the development of bronchiectasis in our patients. However, even some patients diagnosed more recently who had appropriate IgG concentrations developed this complication, as reported in the literature, suggesting that other factors must be involved.…”

“…Furthermore, our study demonstrated the efficacy of immunoglobulin replacement in reducing the frequency and severity of pneumonia in accordance with other studies of patients with PH. [8][9][10][11][12]25,[29][30][31][32] Bronchiectasis was the most frequent tomographic finding in this cohort and its early occurrence was associated with older age at diagnosis and greater diagnostic delay. Plebani et al 3 and Basile et al 6 have already reported the association between age at diagnosis and the presence of bronchiectasis in patients with agammaglobulinemia, as well as Baris et al, 33 who reported this association for patients with CVID.…”

“…[1][2][3][4][5][6][7] Clinically, the most important PHs are: agammaglobulinemia (A), common variable immunodeficiency (CVID) and hyper IgM syndrome (HIGMS), characterized by low serum concentrations of immunoglobulins and that benefit from regular replacement of immunoglobulin, showing a decline in the frequency and severity of infections. [8][9][10][11][12] Even with proper replacement treatment, both international and national studies revealed the presence of bronchiectasis in patients with PH, 5,6,[13][14][15] demonstrating that the decline in infections provided by immunoglobulin replacement does not seem to be enough to prevent the occurrence of pulmonary complications. Chronic pulmonary disease, in particular the development of bron-chiectasis, is one of the most important complications in the evolution of patients, with direct implications regarding their quality of life and mortality.…”

Alterações tomográficas e funcionais pulmonares em pacientes com hipogamaglobulinemia primária em reposição de imunoglobulina humana

“…Clinicamente estes pacientes apresentam ausência ou hipoplasia de tonsilas e gânglios linfáticos, e infecções bacterianas graves ou recorrentes por germes encapsulados que acometem predominantemente os tratos respiratórios superior e inferior (Lederman e Winkelstein, 1985;Plebani et al, 2002;Moin et al, 2004;Winkelstein et al, 2006;Basile et al, 2009 (Roifman et al, 1987;Skull e Kemp, 1996;Plebani et al, 2002;Aghamohammadi et al, 2004).…”