High-dose UVA1 therapy for atopic dermatitis: Results of a multicenter trial

Krutmann, Jean; Diepgen, Thomas L.; Luger, Thomas A.; Grabbe, Stephan; Meffert, H; Sönnichsen, N; Czech, Wolfgang; Kapp, Alexander; Stege, Helger; Grewe, Markus; Schöpf, Erwin

doi:10.1016/s0190-9622(98)70123-9

Cited by 197 publications

(138 citation statements)

References 16 publications

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“…In addition, UVA1-induced upregulation of CD95L could be blocked by the electron quencher sodium azide, implying that the formation of singlet oxygen species is involved. This observation might be of clinical relevance, since UVA1 is known to improve atopic dermatitis, a T cell-mediated disease (43). Enhanced T cell apoptosis was detected in situ in skin samples obtained from atopic patients undergoing UVA1 phototherapy (42).…”

Section: Death Receptors On the Cell Membrane Are Involved In Uv-indumentioning

confidence: 80%

Molecular mechanisms of UV‐induced apoptosis

Kulms

Schwarz

2000

Photoderm Photoimm Photomed

281

206

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Sunburn cells, single standing cells with typical morphologic features occurring in UV-exposed skin, have been recognized as keratinocytes undergoing apoptosis following UV irradiation. Induction of apoptosis following UV exposure appears to be a protective mechanism, getting rid off severely damaged cells that bear the risk of malignant transformation. UV-mediated apoptosis is a highly complex process in which different molecular pathways are involved. These include DNA damage, activation of the tumor suppressor gene p53, triggering of cell death receptors

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Section: Death Receptors On the Cell Membrane Are Involved In Uv-indumentioning

confidence: 80%

Molecular mechanisms of UV‐induced apoptosis

Kulms

Schwarz

2000

Photoderm Photoimm Photomed

281

206

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“…All volunteers were exposed to a geometric dose series of UV-A1 irradiation (7,10,14,20,28,40,56, and 80 J/cm 2 for those with skin types I and II, with an additional dose of 112 J/cm 2 , while omitting the lowest dose for those of skin types III and IV; 1.4 incremental factor) at 2 test sites (photoprotected lower back and inner forearm skin; 8ϫ1.5 cm 2 test areas).…”

Section: Irradiationmentioning

confidence: 99%

Dose-Response and Time-Course Characteristics of UV-A1 Erythema

Beattie

Dawe²,

Ferguson³

et al. 2005

Arch Dermatol

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“…However, there is still some controversy about the optimal UVA1 single and cumulative dose. So far, the doses applied have ranged from low, with 10–30 J/cm 2 [2], through medium, at 50–60 J/cm 2 [3, 4], to a high-dose regimen [1, 4, 5], with 130 J/cm 2 . For that reason, we compared in a randomized, controlled, prospective pilot study the efficacy of ‘high-dose’ (maximum single dose of 130 J/cm 2 , maximum cumulative dose of 1,840 J/cm 2 ), ‘medium-dose’ (maximum single dose of 65 J/cm 2 , maximum cumulative dose of 975 J/cm 2 ) and ‘low-dose’ (maximum single dose of 20 J/cm 2 , maximum cumulative dose of 300 J/cm 2 ) UVA1 therapy in patients with acutely exacerbated AD (SCORAD >30) [6].…”

Section: Introductionmentioning

confidence: 99%