UVA1 Therapy Dose-Finding Study in Patients with Acute Exacerbated Atopic Dermatitis

Dittmar, Henning C.; Pflieger, D.; Schöpf, Erwin; Simon, Jan C.

doi:10.1159/000053765

Cited by 27 publications

(55 citation statements)

References 7 publications

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“…[12][13][14] Because of concerns about possible long-term side effects of high-dose UVA1 therapy (eg, photodamage and carcinogenesis), the effect of lower doses of UVA1 was studied. 15 The results of this study demonstrated that both high-dose (maximum 130 J/cm 2 ) and medium-dose (MD) (maximum 65 J/cm 2 ) UVA1 are effective, whereas low-dose (maximum 20 J/cm 2 ) UVA1 is not. 15 The clinical effect of MD UVA1 phototherapy in AD has been studied by several authors.…”

mentioning

confidence: 63%

“…15 The results of this study demonstrated that both high-dose (maximum 130 J/cm 2 ) and medium-dose (MD) (maximum 65 J/cm 2 ) UVA1 are effective, whereas low-dose (maximum 20 J/cm 2 ) UVA1 is not. 15 The clinical effect of MD UVA1 phototherapy in AD has been studied by several authors. 16,17 In a bilateral comparison study in 10 patients with AD, Tzaneva et al 18 showed that MD UVA1 is as effective as high-dose UVA1.…”

mentioning

confidence: 63%

See 1 more Smart Citation

Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis

Majoie

Oldhoff

Weelden

et al. 2009

Journal of the American Academy of Dermatology

100

106

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mentioning

confidence: 63%

mentioning

confidence: 63%

Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis

Majoie

Oldhoff

Weelden

et al. 2009

Journal of the American Academy of Dermatology

100

106

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“…The median cumulative UVA-1 dose of 1075 J/cm 2 used in our cohort was comparable to that reported in the dose finding studies in atopic dermatitis. 27 UVA-1 treatment was very well tolerated with reversible tanning and mild erythema including patients requiring the antifungal voriconazole with its known phototoxic potential allowing a continuation of an effective oral antifungal treatment in an outpatient setting.…”

Section: Discussionmentioning

confidence: 99%

UVA (UVA-1) therapy for the treatment of acute GVHD of the skin

Schlaak

Schwind

Wetzig³

et al. 2010

Bone Marrow Transplant

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Long-wavelength UVA (340-400 nm UVA-1) phototherapy has been reported to be effective in atopic dermatitis, localized scleroderma and T-cell-derived skin diseases. We retrospectively investigated 70 patients with acute cutaneous GVHD after allogeneic haematopoietic cell transplantation or donor lymphocyte infusion. Complete and partial responses with a median duration of 10 months were achieved in 49 (70%) and 17 (24.3%) patients, respectively. Overall, 47 (67.1%) patients were not treated with systemic steroids. Furthermore, immunosuppression could be tapered in 24 (34.3%) patients while they were receiving UVA-1 treatment. Responses were seen irrespective of age or type of conditioning. Treatment was very well tolerated. After a median follow-up of 18 (range 10-60) months, three patients developed epithelial skin neoplasia. We conclude that UVA-1 therapy is feasible, well tolerated and can be an effective treatment for acute GVHD of the skin, thereby avoiding the use of systemic steroids and/or allowing a more rapid tapering of systemic immunosuppression in a substantial number of patients. The results of this retrospective analysis warrant larger, prospective studies and the effectiveness of UVA-1 therapy should be compared with other established treatment modalities.

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“…We also included a study 19 that evaluated the utility of reflectance-guided UV-B for reducing UV-B dose. Finally, we omitted 1 study 31 included in the other review because it was published in German.…”

Section: Comparison With Previous Systematic Reviewsmentioning

confidence: 99%

Phototherapy in Atopic Dermatitis: A Systematic Review of the Literature

Pérez‐Ferriols

Aranegui

Pujol-Montcusí

et al. 2015

Actas Dermo-Sifiliográficas (English Edition)

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There is evidence for the use of narrow-band UV-B and UV-A1 phototherapy in moderate to severe atopic dermatitis. Evidence supporting the use of PUVA in atopic dermatitis is scarce and there is little information on the use of phototherapy in childhood. For the purpose of future studies, it would be advisable to use comparable criteria and scales for the evaluation of disease severity and patients, to standardize radiation methods, and to establish a minimum follow-up time.

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UVA1 Therapy Dose-Finding Study in Patients with Acute Exacerbated Atopic Dermatitis

Cited by 27 publications

References 7 publications

Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis

Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis

UVA (UVA-1) therapy for the treatment of acute GVHD of the skin

Phototherapy in Atopic Dermatitis: A Systematic Review of the Literature

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