High Dose Supplementation of RRR-α-Tocopherol Decreases Cellular Hemostasis but Accelerates Plasmatic Coagulation in Type 2 Diabetes Mellitus

Ferber, Philippe; Moll, Kevin; Koschinsky, T.; Rosén, P.; Susanto, F.; Schwippert, B.; Tschöpe, D

doi:10.1055/s-2007-978818

Cited by 10 publications

(3 citation statements)

References 14 publications

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“…In fact, Devaraj et al have reported that IL-1b and TNF-a are elevated in diabetic patients with macroangiopathy, and that the adminis- Original Basic tration of a-tocopherol decreased the levels of these cytokines, suggesting that a-tocopherol supplementation in diabetic patients could result in a reduction in diabetic macroangiopathy [22]. Ferber et al have reported that the supplementation of atocopherol decreases the LDL oxidation and the expression of platelet adhesion molecules in diabetic patients [23]. However, there is little evidence to show the effect of a-tocopherol on the production of pro-inflammatory cytokines in endothelial cells.…”

Section: Discussionmentioning

confidence: 99%

α-Tocopherol Inhibits IL-8 Synthesis Induced by Thrombin and High Glucose in Endothelial Cells

Nobata¹,

Urakaze²,

Temaru³

et al. 2002

Horm Metab Res

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It has been reported that alpha-tocopherol, an antioxidant agent, may play a role in preventing diabetic angiopathy. However, there is little evidence to show the effect of alpha-tocopherol on the production of pro-inflammatory cytokines in endothelial cells. Therefore, we examined the effect of alpha-tocopherol on the regulation of IL-8 synthesis induced by high glucose and/or thrombin in endothelial cells. Thrombin alone markedly increased the IL-8 release. Furthermore, high glucose levels and thrombin combined had additive effects on IL-8 synthesis, and alpha-tocopherol diminished their effect; alpha-tocopherol also inhibited the phosphorylation of IkappaB-alpha induced by high glucose levels and/or thrombin. Our results suggest that the administration of alpha-tocopherol to diabetic patients may have a beneficial effect for the prevention of diabetic vascular complications by the inhibition of IL-8 synthesis from endothelial cells.

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Section: Discussionmentioning

confidence: 99%

α-Tocopherol Inhibits IL-8 Synthesis Induced by Thrombin and High Glucose in Endothelial Cells

Nobata¹,

Urakaze²,

Temaru³

et al. 2002

Horm Metab Res

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show abstract

“…Adhesion of platelet and leukocytes into the vascular endothelial cell by the increased expression of intercellular adhesion molecule-1 (ICAM-1) is a crucial step in thrombosis/atherogenesis [ 12 ]. Suppressed expression of ICAM-1 was associated with reduced adherence of monocytes, lymphocytes and platelets to oxidized LDL stimulated endothelial cells [ 13 , 12 ]. The defense of vascular endothelium against the damage caused by ROS and dyslipidemia is probably an important factor for reduction of thrombotic and atherosclerotic attack [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Partially hydrolyzed guar gum supplement reduces high-fat diet increased blood lipids and oxidative stress and ameliorates FeCl3-induced acute arterial injury in hamsters

2009

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Increased reactive oxygen species (ROS) and hyperlipidemia can promote arterial thrombus. We evaluated the potential of a partially hydrolyzed guar gum (PHGG) as dietary fiber on lipid profiles and FeCl 3 -induced arterial thrombosis in the high fat-diet fed hamsters. Our in vitro results found that PHGG is efficient to scavenge O 2 -•, H 2 O 2 , and HOCl. High fat-diet increased plasma triglyceride, total cholesterol, LDL, VLDL, methylguanidine and dityrosine level and accelerated FeCl 3 -induced arterial thrombosis formation (from 463 ± 51 to 303 ± 45 sec). Low dose PHGG supplement significantly decreased the total cholesterol, LDL, methylguanidine and dityrosine level and delayed the time for arterial thrombosis formation (528 ± 75 sec). High dose PHGG supplement decreased the level in triglyceride, total cholesterol, LDL and VLDL and further delayed the time for arterial thrombus (671 ± 36 sec). The increased Bax protein and decreased Bcl-2 and HSP-70 protein expression was found in the carotid and femoral arteries of high fat-diet hamsters. Low and high dose of PHGG supplement decreased Bax expression and increased Bcl-2 and HSP-70 protein expression. We found that FeCl 3 significantly enhanced intercellular adhesion molecule-1 and 4-hydroxynonenal expression in the endothelial site of damaged artery after 150-sec FeCl 3 stimulation. PHGG supplement decreased the endothelial ICAM-1 and 4-hydroxynonenal expression after 150-sec FeCl 3 stimulation. Based on these results, we conclude that PHGG supplement can increase antioxidant protein expression and thus decrease oxidative stress induced arterial injury.

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“…By implication this would diminish thrombus formation (17). For instance, with thrombocytes vitamin E treatment resulted in reduced expression of PECAM and ICAM (18), although it remains uncertain whether reduced expression of adhesion molecules alone would prevent aggregation in diseased regions of the blood vessel. Further, there is speculation for vitamin E to reduce thrombocyte aggregation through diminished insult of the blood vessel by ROS and thus would improve NO availability (19,20).…”

Section: Discussionmentioning

confidence: 99%

Vitamin E in Heart Transplantation: Effects on Cardiac Gene Expression

et al. 2006

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High Dose Supplementation of RRR-α-Tocopherol Decreases Cellular Hemostasis but Accelerates Plasmatic Coagulation in Type 2 Diabetes Mellitus

Cited by 10 publications

References 14 publications

α-Tocopherol Inhibits IL-8 Synthesis Induced by Thrombin and High Glucose in Endothelial Cells

α-Tocopherol Inhibits IL-8 Synthesis Induced by Thrombin and High Glucose in Endothelial Cells

Partially hydrolyzed guar gum supplement reduces high-fat diet increased blood lipids and oxidative stress and ameliorates FeCl3-induced acute arterial injury in hamsters

Vitamin E in Heart Transplantation: Effects on Cardiac Gene Expression

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