Vitamin E in Heart Transplantation: Effects on Cardiac Gene Expression

Schulte, Ingo; Bektaş, H.; Klempnauer, Jürgen; Borlak, Jürgen

doi:10.1097/01.tp.0000191661.90834.b5

Cited by 6 publications

(4 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among these, α -tocopherol is the best known and possesses the most antioxidant activity (171). In addition to its direct antioxidant properties, growing evidence suggests that some of the beneficial effects of vitamin E in cells resides in its ability to regulate gene expression of proteins (30, 31, 139, 349). …”

Section: Antioxidant Defense Systems: Overview and Response To Cmentioning

confidence: 99%

Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production

Powers¹,

Jackson²

2008

Physiological Reviews

1,915

1,895

View full text Add to dashboard Cite

The first suggestion that physical exercise results in free radical-mediated damage to tissues appeared in 1978, and the past three decades have resulted in a large growth of knowledge regarding exercise and oxidative stress. Although the sources of oxidant production during exercise continue to be debated, it is now well established that both resting and contracting skeletal muscles produce reactive oxygen species and reactive nitrogen species. Importantly, intense and prolonged exercise can result in oxidative damage to both proteins and lipids in the contracting myocytes. Furthermore, oxidants can modulate a number of cell signaling pathways and regulate the expression of multiple genes in eukaryotic cells. This oxidant-mediated change in gene expression involves changes at transcriptional, mRNA stability, and signal transduction levels. Furthermore, numerous products associated with oxidant-modulated genes have been identified and include antioxidant enzymes, stress proteins, DNA repair proteins, and mitochondrial electron transport proteins. Interestingly, low and physiological levels of reactive oxygen species are required for normal force production in skeletal muscle, but high levels of reactive oxygen species promote contractile dysfunction resulting in muscle weakness and fatigue. Ongoing research continues to probe the mechanisms by which oxidants influence skeletal muscle contractile properties and to explore interventions capable of protecting muscle from oxidant-mediated dysfunction.

show abstract

Section: Antioxidant Defense Systems: Overview and Response To Cmentioning

confidence: 99%

Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production

Powers¹,

Jackson²

2008

Physiological Reviews

1,915

1,895

View full text Add to dashboard Cite

show abstract

“…Among these, α-tocopherol possesses the greatest antioxidant activity (186). In addition to its direct antioxidant properties, evidence indicates that the beneficial effects of vitamin E in cells also comes from its ability to control gene expression of several proteins (34, 35, 151, 358). …”

Section: Introductionmentioning

confidence: 99%

Reactive Oxygen Species: Impact on Skeletal Muscle

Powers

Kavazis

et al. 2011

Comprehensive Physiology

387

384

View full text Add to dashboard Cite

It is well established that contracting muscles produce both reactive oxygen and nitrogen species. Although the sources of oxidant production during exercise continue to be debated, growing evidence suggests that mitochondria are not the dominant source. Regardless of the sources of oxidants in contracting muscles, intense and prolonged exercise can result in oxidative damage to both proteins and lipids in the contracting myocytes. Further, oxidants regulate numerous cell signaling pathways and modulate the expression of many genes. This oxidant-mediated change in gene expression involves changes at transcriptional, mRNA stability, and signal transduction levels. Furthermore, numerous products associated with oxidant-modulated genes have been identified and include antioxidant enzymes, stress proteins, and mitochondrial electron transport proteins. Interestingly, low and physiological levels of reactive oxygen species are required for normal force production in skeletal muscle, but high levels of reactive oxygen species result in contractile dysfunction and fatigue. Ongoing research continues to explore the redox-sensitive targets in muscle that are responsible for both redox-regulation of muscle adaptation and oxidant-mediated muscle fatigue.

show abstract

“…6 Low doses of vitamin E supplementation (~47mg /kg body wt/day for 2 wks and ~94 mg/kg body wt/day for 4 wks) significantly reduced genes coding for superoxide dismutase, an oxygen detoxifing enzyme, and intracellular adhesion molecule (ICAM)-1 in cardiac tissue of Lewis rats. 29 In humans, the α-tocopherol pro-oxidative action has been suggested by high susceptibility to hydrogen peroxide-induced peroxidation of erythrocytes found in non-smoking men supplemented with d -α-tocopherol acetate (1050 mg/day) for 20 wks. 30 A meta-analysis of clinical trials studying vitamin E suggests that the use of vitamin E greater than 400 IU/day may increase mortality in patients with coronary disease.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological dose of α-tocopherol induces cardiotoxicity in Wistar rats determined by echocardiography and histology

Nascimento

Matsubara

et al. 2011

Hum Exp Toxicol

View full text Add to dashboard Cite

The effect of pharmacological dose of α-tocopherol on heart health was determined in Wistar rats. Animals were randomly assigned to either C (control, n = 11) or E (α-tocopherol, n = 11) group. Animals received corn oil (C) or α-tocopherol dissolved in corn oil (250 mg α-tocopherol/[kg body wt/day]) (E) by gavage for a 7-week period. Rats underwent echocardiogram and were analyzed for cardiomyocyte histology and cardiac α-tocopherol absorption at the end of the study period. As compared to the C group, α-tocopherol-supplemented group showed significantly ( p < 0.05) lower body weight (E, 412.8 g vs C, 480.3 g) and total cardiac weight (E, 0.94 g vs C, 1.08 g); cardiomyocyte histological impairment; smaller left ventricle (LV) (LV end-diastolic diameter (E, 7.22 mm vs C, 7.37 mm), lower LV systolic [left ventricle fractional shortening (E, 47.6% vs C, 53.6%) and ejection fraction ratio (E, 85.4 vs C, 89.9)] and diastolic [early peak velocities of diastolic transmitral flow (E, 64.6 cm/sec vs C, 75.1 cm/sec)] function. The α-tocopherol uptake in target tissue was confirmed by determination of α-tocopherol concentration medians in cardiac tissue (E, 109.91 nmol/kg vs C, 52.09 nmol/kg). The current study indicates that pharmacological dose of α-tocopherol supplementation can induce cardiotoxicity in healthy rats.

show abstract

Vitamin E in Heart Transplantation: Effects on Cardiac Gene Expression

Abstract: Based on transcript profiling, we propose a novel role of vitamin E in transplant surgery. Our findings warrant further studies to explore its clinical application.

Cited by 6 publications

References 51 publications

Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production

Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production

Reactive Oxygen Species: Impact on Skeletal Muscle

Pharmacological dose of α-tocopherol induces cardiotoxicity in Wistar rats determined by echocardiography and histology

Contact Info

Product

Resources

About