High Density Lipoproteins and Diabetes

Cochran, Blake J.; Manandhar, Bikash; Rye, Kerry‐Anne

doi:10.3390/cells10040850

Cited by 37 publications

(41 citation statements)

References 128 publications

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“…The presence of DM eliminated the protective effect of HDL-C on the progression of atherosclerosis, and furthermore, HbA1c was found to be negatively correlated with the efficacy of lipid-lowering therapy [ 20 , 22 ]. In contrast, HDL-C has potent antidiabetic properties via increasing insulin sensitivity and β -cell function, reflecting its role in regulating blood glucose homeostasis [ 23 – 25 ]. In this study, the HbA1c/HDL-C ratio marker could comprehensively reflect blood glucose homeostasis and dyslipidemia, which can be used to monitor progression of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

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Association between the Plasma-Glycosylated Hemoglobin A1c/High-Density Lipoprotein Cholesterol Ratio and Carotid Atherosclerosis: A Retrospective Study

Wang

et al. 2021

Journal of Diabetes Research

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Background. Diabetes mellitus (DM) and dyslipidemia are the main risk factors for atherosclerosis. Elevated glycosylated hemoglobin A1c (HbA1c) and reduced high-density lipoprotein cholesterol (HDL-C) are associated with the progression of atherosclerosis. The aim of this study is at exploring the relationship between the HbA1c/HDL-C ratio and atherosclerosis evaluated using carotid artery intima-media thickness (cIMT) and carotid artery plaque. Methods. In this retrospective study, we enrolled 1304 patients who had multiple cardiovascular risk factors or symptoms of suspected coronary artery disease. cIMT and carotid artery plaque were measured using ultrasonography. Logistic regression was used to explore the correlation between the HbA1c/HDL-C ratio and cIMT or carotid artery plaque. We used restricted cubic spline curves to assess nonlinear relationships between the HbA1c/HDL-C ratio and cIMT or carotid artery plaque. Results. With increased quartiles of HbA1c/HDL-C, patients had higher cIMT and a greater carotid plaque burden. After adjusting for other relevant clinical covariates, patients with the highest HbA1c/HDL-C ratio (quartile 4 (Q4)) had a 2.88 times (95% confidence interval (CI): 2.02–4.10, P < 0.001 ) more abnormal mean cIMT, 3.72 times (95% CI: 2.55–5.44, P < 0.001 ) more abnormal maximum cIMT, and 2.58 times (95% CI: 1.70–3.91, P < 0.001 ) greater carotid artery plaque burden compared with patients who had the lowest HbA1c/HDL-C ratio (Q1). Moreover, the association of HbA1c/HDL-C with atherosclerosis remained significant in a subsample of patients with and without DM. Conclusion. As a novel compound indicator for evaluating blood glucose homeostasis and dyslipidemia, the HbA1c/HDL-C ratio was positively correlated with carotid atherosclerosis evaluated using the mean and maximum cIMT as well as the carotid artery plaque burden.

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Section: Discussionmentioning

confidence: 99%

“…The presence of DM eliminates the vascular protective effect of HDL-C, and poor blood glucose control is an independent risk factor for low HDL-C in DM [ 21 , 22 ]. In turn, HDL-C can reduce blood glucose in patients with DM by increasing plasma insulin [ 23 – 25 ].…”

Section: Introductionmentioning

confidence: 99%

Association between the Plasma-Glycosylated Hemoglobin A1c/High-Density Lipoprotein Cholesterol Ratio and Carotid Atherosclerosis: A Retrospective Study

Wang

et al. 2021

Journal of Diabetes Research

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“…HDL glycation is typically found in patients with diabetic backgrounds and is characterized by covalent attachment of sugar residues. Glycated HDL particles induce endothelial cell apoptosis and increase oxidative stress [65,66] and smooth muscle cell proliferation and migration [67]. Glycation of ApoA-I seems to lead to conformational changes at the site for LCAT activation [66,68] and reduces HDL CEC [69] and its ability to inhibit the expression of adhesion molecules [70].…”

Section: Glycationmentioning

confidence: 99%

“…Glycated HDL particles induce endothelial cell apoptosis and increase oxidative stress [65,66] and smooth muscle cell proliferation and migration [67]. Glycation of ApoA-I seems to lead to conformational changes at the site for LCAT activation [66,68] and reduces HDL CEC [69] and its ability to inhibit the expression of adhesion molecules [70]. In patients with type 2 diabetes, glycated ApoA-I is associated with the severity of CAD and coronary artery plaque progression [71,72] and significantly reduces ApoA-I half-life [73].…”

Section: Glycationmentioning

confidence: 99%

Unraveling the Complexity of HDL Remodeling: On the Hunt to Restore HDL Quality

2021

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Increasing evidence has cast doubt over the HDL-cholesterol hypothesis. The complexity of the HDL particle and its proven susceptibility to remodel has paved the way for intense molecular investigation. This state-of-the-art review discusses the molecular changes in HDL particles that help to explain the failure of large clinical trials intending to interfere with HDL metabolism, and details the chemical modifications and compositional changes in HDL-forming components, as well as miRNA cargo, that render HDL particles ineffective. Finally, the paper discusses the challenges that need to be overcome to shed a light of hope on HDL-targeted approaches.

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“…A decrease in the level of ApoA1 in the blood of diabetic patients and an increase in the risk of CVD were noted in many studies [5][6][7][8].…”

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confidence: 99%

Apolipoprotein A1 level in plasma of patients with diabetes and diabetic patients with COVID-19 as a possible marker of disease

Тronko

Cherviakova

Pushkarev

et al. 2021

Dopov. Nac. akad. nauk Ukr.

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Increased levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A1 (ApoA1) in plasma is associated with a reduced risk of developing cardiovascular diseases (CVD). In addition to its potential cardioprotective function, HDL and ApoA1, the main HDL apolipoprotein, also have antidiabetic properties. The aim of the study was to determine the level of ApoA1 in the blood of patients (n = 81) with type 2 diabetes mellitus and COVID-19. ApoA1 was determined by enzyme-linked immunosorbent assay (ELISA) (Elabscience, USA). The measurements were performed at an optical density of 450 nm. We showed that the level of ApoA1 in the blood of patients with type 2 diabetes and especially with COVID-19 was significantly lower than in the blood of healthy people. Blood ApoA1 levels did not show a further decrease in patients with both COVID-19 and diabetes compared with patients with COVID-19 without diabetes. Thus, the level of ApoA1 may be one of the promising markers of severe COVID-19.

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High Density Lipoproteins and Diabetes

Cited by 37 publications

References 128 publications

Association between the Plasma-Glycosylated Hemoglobin A1c/High-Density Lipoprotein Cholesterol Ratio and Carotid Atherosclerosis: A Retrospective Study

Association between the Plasma-Glycosylated Hemoglobin A1c/High-Density Lipoprotein Cholesterol Ratio and Carotid Atherosclerosis: A Retrospective Study

Unraveling the Complexity of HDL Remodeling: On the Hunt to Restore HDL Quality

Apolipoprotein A1 level in plasma of patients with diabetes and diabetic patients with COVID-19 as a possible marker of disease

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