High dairy products intake reduces osteoporosis risk in Korean postmenopausal women: A 4 year follow-up study

Park, Seon-Joo; Jung, Ji Hye; Kim, Myung-Sunny; Lee, Hae‐Jeung

doi:10.4162/nrp.2018.12.5.436

Cited by 15 publications

(11 citation statements)

References 31 publications

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“…In a prospective cohort study, researchers measured the BMD of the radius and tibia with ultrasound equipment. They found that intake of dairy products may reduce the incidence of radial osteoporosis in Korean postmenopausal women, but there is no significant effect in the tibia ( 15 ). The study also confirmed that milk might affect on bone density in other parts of the body ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

“…There is no evidence to suggest that dairy products have any causal effect on preventing osteoporosis, and research is still ongoing regarding the issue ( 13 , 14 ). Finnish study reports that high calcium intake in older and younger women is positively associated with non-weight-bearing radius but not with weight-bearing tibia ( 15 ). Another study also showed that the intake of calcium-rich foods such as milk was positively related to radial bone density, and it seemed that non-weight-bearing bone density benefited from high calcium intake, while weight-bearing bones like the femur and spine benefited from physical activity ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

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Genetically Predicted Milk Intake Increased Femoral Neck Bone Mineral Density in Women But Not in Men

et al. 2022

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BackgroundCow milk contains more calcium, magnesium, potassium, zinc, and phosphorus minerals. For a long time, people have believed that increasing milk intake is beneficial to increasing bone density. Many confounding factors can affect milk consumption, and thus the association described to date may not be causal. We explored the causal relationship between genetically predicted milk consumption and Bone Mineral Density (BMD) of the femoral neck and lumbar spine based on 53,236 individuals from 27 studies of European ancestry using the Mendelian randomization (MR) study. 32,961 individuals of European and East Asian ancestry were used for sensitivity analysis.MethodsA genetic instrument used for evaluating milk consumption is rs4988235, a locus located at 13,910 base pairs upstream of the LCT gene. A Mendelian randomization (MR) analysis was conducted to study the effect of selected single nucleotide polymorphisms (SNPs) and BMD. The summary-level data for BMD of the femoral neck and lumbar spine were obtained from two GWAS meta-analyses [‘Data Release 2012’ and ‘Data Release 2015’ in the GEnetic Factors for OSteoporosis Consortium (GEFOS)].Resultswe found that genetically predicted milk consumption was not associated with FN-BMD(OR 1.007; 95% CI 0.991–1.023; P = 0.385), LS-BMD(OR 1.003; 95% CI 0.983–1.024; P = 0.743) by performing a meta-analysis of several different cohort studies. High levels of genetically predicted milk intake were positively associated with increased FN-BMD in Women. The OR for each additional milk intake increasing allele was 1.032 (95%CI 1.005–1.059; P = 0.014). However, no causal relationship was found between milk consumption and FN-BMD in men (OR 0.996; 95% CI 0.964–1.029; P = 0.839). Genetically predicted milk consumption was not significantly associated with LS-BMD in women (OR 1.017; 95% CI 0.991–1.043; P = 0.198) and men (OR 1.011; 95% CI 0.978–1.045; P = 0.523).ConclusionOur study found that women who consume more milk have a higher FN-BMD. When studying the effect of milk consumption on bone density in further studies, we need to pay more attention to women.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genetically Predicted Milk Intake Increased Femoral Neck Bone Mineral Density in Women But Not in Men

et al. 2022

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“…In a 4-year prospective cohort study on postmenopausal women, a milk intake exceeding 5-6 servings per week decreased the risk of radial but not tibial osteoporosis (hazard ratio, 0.60; 95% CI, 0.42-0.87) compared with 0 weekly servings. 16) Studies have also been conducted using the KNHANES. Hong et al 17) found varying degrees of osteoporosis risk compared to those who consumed no dairy; those who consumed either less than once or more than once daily had an OR of either 0.96 (95% CI, 0.66-1.38) or 0.71 (95% CI, 0.53-0.96), respectively.…”

Section: Discussionmentioning

confidence: 99%

“…A few studies in Korea have shown an association between milk consumption, BMD, and osteoporosis. In a 4-year prospective cohort study on postmenopausal women, a milk intake exceeding 5–6 servings per week decreased the risk of radial but not tibial osteoporosis (hazard ratio, 0.60; 95% CI, 0.42–0.87) compared with 0 weekly servings [ 16 ]. Studies have also been conducted using the KNHANES.…”

Section: Discussionmentioning

confidence: 99%

Milk Consumption and Bone Mineral Density in Adults: Using Data from the Korea National Health and Nutrition Examination Survey 2008–2011

Kim

2021

Korean J Fam Med

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Background: Milk consumption is associated with bone mineral density (BMD), but reports are limited in terms of participant age, sex, and number of study subjects. We investigated the association between milk consumption and BMD in South Korean adults (≥20 years).Methods: We analyzed men and women aged ≥20 years who participated in the Korean National Health and Nutrition Examination Survey, 2008–2011. We used linear regression to calculate the mean BMD and 95% confidence interval (CI) based on the frequency of milk consumption. Multivariate logistic regression analysis was used to estimate the odds ratios (ORs) and 95% CI for T-scores ≤-2.5 (osteoporosis) in both men aged ≥50 years and postmenopausal women.Results: In total 8,539 subjects were studied. Drinking milk more than once a day was associated with higher BMD in the total femur and femoral neck in men aged <50 years and lumbar spine in men aged ≥50 years, compared to less than once a week. It was also associated with lower ORs for osteoporosis of the femoral neck and lumbar spine in men aged ≥50 years (OR, 0.35; 95% CI, 0.125–0.979 and OR, 0.34; 95% CI, 0.143–0.804, respectively). In postmenopausal women who consumed milk 2–6 times weekly, higher BMD and lower OR for osteoporosis were observed in the total femur (OR, 0.23; 95% CI, 0.055–0.958).Conclusion: This study suggests that frequent milk consumption could potentially reduce osteoporosis incidence in South Korean adults. Further prospective study is necessary to elucidate the effect of milk consumption on BMD.

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“…Furthermore, in a cross-sectional study, a higher dairy consumption was associated with lower prevalence of falls, greater lean body mass and better physical performance in women (14). Likewise, dairy products have been associated with greater muscle mass (14,15) and greater bone mineral density (16), as well as with lower risk of osteoporosis and functional disability (17)(18)(19)(20). These results might suggest that dairy intake could prevent falls through the improvement of the musculoskeletal system.…”

Section: Introductionmentioning

confidence: 93%

Dairy consumption and risk of falls in 2 European cohorts of older adults

et al. 2020

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Background & aims: Some previous evidence have linked dairy products with greater muscle mass, bone mineral density and lower risk of osteoporosis. However, other authors have found a detrimental effect of milk on the risk of hip fracture. The aim of this study was to assess the prospective association between dairy consumption and risk of falls in older adults. Methods: We used data from 2 cohorts of community-dwellers aged ≥60y: the Seniors-ENRICA cohort with 2,981 individuals, and the UK Biobank cohort with 8,927 participants. In the Seniors-ENRICA, dairy consumption was assessed with a validated diet history in 2008-10, and falls were ascertained up to 2015. In the UK Biobank study, dairy consumption was obtained with 3-5 multiple-pass 24-h food records in 2006-10, and falls were assessed up to 2016.

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High dairy products intake reduces osteoporosis risk in Korean postmenopausal women: A 4 year follow-up study

Cited by 15 publications

References 31 publications

Genetically Predicted Milk Intake Increased Femoral Neck Bone Mineral Density in Women But Not in Men

Genetically Predicted Milk Intake Increased Femoral Neck Bone Mineral Density in Women But Not in Men

Milk Consumption and Bone Mineral Density in Adults: Using Data from the Korea National Health and Nutrition Examination Survey 2008–2011

Dairy consumption and risk of falls in 2 European cohorts of older adults

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