We have investigated the temperature dependence of microwave losses in the low-power limit and millikelvin temperature range of a thin-film YBa 2 Cu 3 O 7−x (YBCO) λ/2 coplanar waveguide resonator patterned on a (La 0.3 Sr 0.7 ) (Al 0.65 Ta 0.35 )O 3 (LSAT) substrate covered by a CeO 2 seed layer. The unloaded quality factor is mainly governed by the surface resistance of the YBCO film and the dielectric losses caused by resonant absorption due to a bath of two-level fluctuators in the dielectrics. The value of the unloaded quality factor at 20 mK and low power, i.e., Q 0 2000, allows for the realization of YBCO microwave quantum circuits implementing biepitaxial grain-boundary Josephson junctions.Index Terms-Dielectric losses, high critical temperature supreconductors, superconducting microwave devices, superconducting thin films, surface resistance, yttrium barium copper oxide (YBCO).