High antimüllerian hormone levels are associated with preterm delivery in patients with polycystic ovary syndrome

Hu, Kai-Lun; Liu, Fen-Ting; Xu, Huiyu; Li, Rong; Qiao, Jie

doi:10.1016/j.fertnstert.2019.09.039

Cited by 28 publications

(24 citation statements)

References 33 publications

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“…Furthermore, parameters reflecting the quantity of ovarian reserve including AFC, number of retrieved oocytes and transferable embryos do not reflect the quality of oocytes and embryos. Moreover, our results did not include pregnancy complications, while PCOS was reported to be associated with gestational diabetes, pregnancy-induced hypertension, and premature delivery (54,55).…”

Section: Discussionmentioning

confidence: 86%

Comparison of Cumulative Live Birth Rate Between Aged PCOS Women and Controls in IVF/ICSI Cycles

et al. 2021

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The present study aimed to assess whether women with polycystic ovarian syndrome (PCOS) ≥35 years age undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles experienced a higher cumulative live birth rate (CLBR) over a two-year period compared with age- and body mass index (BMI)-matched patients with tubal factor infertility. Through propensity score matching (PSM) approach, the authors retrospectively analyzed the IVF/ICSI outcomes of 263 PCOS patients (35-46 years of age [mean, 37 years]) and 526 age- and BMI-matched tubal factor controls two years after oocyte retrieval. Multivariate regression analysis was performed to explore factors influencing cumulative live birth. Women with PCOS exhibited better ovarian reserve and response, and higher CLBR in two years compared with age- and BMI-matched controls (CLBR: 55.51% in PCOS vs. 38.02% in control, p<0.001). Multivariate logistic regression analysis revealed that the number of transferable embryos and antral follicle counts were both significant independent factors predicting cumulative live birth after adjusting for female age, female body mass index, percentage of transferred blastocysts, number of embryos transferred per embryo-transfer cycle, diagnosis of PCOS and freeze-all cycles (p<0.001, p=0.045). Women with PCOS ≥ 35 years of age demonstrated a higher CLBR over two years compared with age- and BMI-matched controls. This could be explained by favorable oocyte reserve and more available embryos compared with controls, which overcome the compromised oocyte quality in aged PCOS patients.

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Section: Discussionmentioning

confidence: 86%

Comparison of Cumulative Live Birth Rate Between Aged PCOS Women and Controls in IVF/ICSI Cycles

et al. 2021

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“…Thus, underlying inflammatory mediators associated with PCOS may also contribute to predisposition for preterm delivery. Additionally, a recent study showed that higher antimüllerian hormone (AMH) levels were a risk factor for preterm delivery in women with PCOS (21). This result may be explained by the higher AMH level observed in PCOS women during pregnancy was considered to have an impact on the endocrine system of the fetus and offspring (22).…”

Section: Discussionmentioning

confidence: 99%

Pregnancy Outcomes of Women With Polycystic Ovary Syndrome for the First In Vitro Fertilization Treatment: A Retrospective Cohort Study With 7678 Patients

Liu

Xiao

et al. 2020

Front. Endocrinol.

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Background: The risk of adverse pregnancy outcomes is increased by having a polycystic ovary syndrome (PCOS) diagnosis. However, the confounders in previous studies preclude firm conclusions, and further studies are warranted. Objectives: To investigate whether PCOS affects pregnancy outcomes and complications in infertile women undergoing their first in vitro fertilization (IVF) treatment, taking into account important confounders. Methods: We performed a retrospective cohort study of 7,678 infertile women, including 666 women with PCOS and 7,012 controls undergoing their first IVF treatment at a private fertility center from January 2010 to December 2017. Our main outcome was the impact of PCOS on adverse pregnancy outcomes (miscarriage, preterm delivery, pregnancyinduced hypertension) and pregnancy outcomes (live birth rate, clinical pregnancy rate, implantation rate). PCOS effects were summarized by adjusted odds ratios (aORs) with 95% confidence intervals (CIs) after controlling for maternal characteristics. Results: After adjusting for differences in maternal age, BMI, infertility duration, total dose of gonadotropin, serum E 2 and endometrial thickness on the day of hCG trigger, number of fertilized occytes, number of embryos transferred, embryo type (cleavage-stage embryo or blastocyst) and quality, women with PCOS had an increased risk of developing unfavorable pregnancy complications, including miscarriage (aOR 1.629, 95% CI 1.240-2.141), very preterm delivery (< 32 weeks) (aOR 2.072, 95% CI 1.133-3.791). For pregnancy outcomes, PCOS was associated with higher clinical pregnancy rate (aOR 1.248, 95% CI 1.038-1.501) and implantation rate (aOR 1.238, 95% CI 1.030-1.489) after adjusting for the above-mentioned confounders.

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“…And the presence of scientific evidences in the literature indicating that in pregnant diagnosed with PCOS had a higher preterm delivery rate, especially those whom had higher AMH levels, emboldened us to plan this research. (8)(9)(10) When PCOS patients are evaluated within themselves, the most frequently detected abnormality was Figure II which is classified as class VI in ASRM classification and is accepted as a variance of normal, not abnor-mality, in ESGE -ESHRE classification, named as arcuate. When the arcuate cavity is considered normal as in the ESGE -ESHRE classification, in terms of uterine cavity abnormalities, the statistically significant difference disappears between PCOS and control patients.…”

Section: Discussionmentioning

confidence: 99%

Pcos and Uteri̇ne Abnormality; Possible Connection and Relationship With Maternal Serum Amh Levels

Uncu¹,

Aslan²,

Albayrak³

et al. 2020

Preprint

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Objective: To determine the incidence of uterine abnormalities in patients with PCOS Design: Retrospective Cohort Study Setting: Tertiary University Hospital Population: Infertile patients with PCOS vs. male factor infertility were selected from the IVF center electronic database from between the years 2011-2019. Methods: A total of 103 patients, 51 PCOS, and 52 male factor infertility were enrolled in the study. Hysterosalpingography (HSG) images of all patients were numbered. For the study, six different shapes of the intrauterine cavity were figured. All HSG images were evaluated by ten senior reproductive endocrinologists and surgeons. Seniors were blinded to the research and chose the most appropriate figure for each patient's HSG image. Results and Demographic parameters were compared between PCOS and Male Factor Groups. Anti-Mullerian hormone correlation with Uterine abnormality was further analyzed. Main Outcome Measure: Percentage of the abnormal uterine cavity Results: The percentage of the normal uterine cavity was significantly lower in the PCOS group. (45.9 % and 73.1 %, p<0.01) The abnormal cavities were compared; Arcuate Uterus (22.18% vs 6.6% p<0.05), Partial Septate Uterus (5.1% vs 0% p<0.05), Complete Septate Uterus (5.47% vs 1.2% p<0.01) and Y-Shaped Uterus (7.47% vs 0 p<0.05) were significantly higher in PCOS patients. T-Shaped Uterus (13.8% vs. 18.9%) was statically similar. There was no correlation between serum AMH levels and the presence of uterine abnormality. Conclusion: This study provides that, compared to the healthy population, the uterine abnormality frequency is clearly higher

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High antimüllerian hormone levels are associated with preterm delivery in patients with polycystic ovary syndrome

Cited by 28 publications

References 33 publications

Comparison of Cumulative Live Birth Rate Between Aged PCOS Women and Controls in IVF/ICSI Cycles

Comparison of Cumulative Live Birth Rate Between Aged PCOS Women and Controls in IVF/ICSI Cycles

Pregnancy Outcomes of Women With Polycystic Ovary Syndrome for the First In Vitro Fertilization Treatment: A Retrospective Cohort Study With 7678 Patients

Pcos and Uteri̇ne Abnormality; Possible Connection and Relationship With Maternal Serum Amh Levels

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