Heterogenized magnetic graphene oxide‐supported N₆‐Schiff base Cu (II) complex as an exclusive nanocatalyst for synthesis of new pyrido[2,3‐d]pyrimidine‐7‐carbonitrile derivatives

Abstract

In this article, the synthesis of a novel and highly efficient recyclable and reusable heterogeneous nanocatalyst has been reported via the functionalizing of the Fe3O4‐magnetized graphene oxide nanosheets with the N6‐Schiff base Cu (II) complex (GO/Fe3O4@SPNC). The structure of this novel nanocatalyst was determined by different analytical techniques such as FTIR, FE‐SEM, TEM, TGA‐DTG, and VSM. The catalytic activity of the synthesized GO/Fe3O4@SPNC nanocatalyst was explored for the synthesis of several new 2H‐pyrido[3′,2′:6,7]pyrano[2,3‐d]pyrimidine‐7‐carbonitrile derivatives with excellent yields. All new derivatives were fully identified by various spectral (1H NMR, 13C NMR, FT‐IR, ESI‐MS) analyses. In addition, this nanocatalyst carried out satisfactory catalytic maintenance of activity and high chemical stability in the titled reactions after seven‐time of recycling without substantial loss of leaching.

A review on pyrimidine‐based derivatives: Synthesis and their biological application

“…The synthesis of pyrimidines and their derivatives can be achieved either by introducing a pre-existing pyrimidine core unit [59,60] or through in situ methods [61][62][63]. Various synthetic strategies of pyrimidine and pyrimidine fused with other carbocycles are summarized in this review.…”

Importance of Hybrid Catalysts toward the Synthesis of 5H-Pyrano[2,3-d]pyrimidine-2-ones/2,4-diones (Thiones)

“…Mahmoudi-Gom Yek et al 65 used a supported heterogeneous N 6 -Schiff base complex coated by Cu(II) on the surface of Fe 3 O 4 -magnetized graphene oxide nanosheets to prepare GO-Fe 3 O 4 @SPNC-catalyzed one-shot synthesis of tricyclopyranopyrimidine 32 along with its diverse analogues by utilizing a three-component equimolar reaction of 1 with 11a and 3-cyano-6-hydroxy-4-methylpyridine-2(1 H )-one 31 under the solvent-free conditions at 70 °C ( Scheme 20 ). The catalyst was reused up to seven times.…”

Synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported by nano-catalysts

“…Consequently, nano-catalysts recently are being widely applied for the construction of compounds with a pyrimidine skeleton. [140][141][142][143][144] Thus, consideration should be given to the productivity of the nano-catalyst relative to other catalysts, and the preparation of nanocatalysts at a lower cost. On the other hand, the ease of nanocatalyst preparation, and its separation from the reaction mixture to be recycled should be considered.…”