A new series of triheterocyclic compounds containing pyrazole, pyran, and pyrimidinone rings was synthesized via a one-pot condensation of ethylacetoacetate, hydrazine hydrate, barbituric acid, and aromatic aldehydes in the presence of catalytic amounts of titanium dioxide nanowires. Various functional groups were well tolerated under the optimized reaction conditions. Synthesis of 5 using TiO 2 nanowiresEthylacetoacetate (0.13 mL, 1 mmol) and TiO 2 NWs (10 mol%) were added to a solution of hydrazine hydrate (96%, 0.05 mL, 1 mmol) in H 2 O/EtOH (5 mL, 50/50) over 20 min. Then, Scheme 2 Suggested mechanism for the synthesis of triheterocyclic compounds 5 using TiO 2 NWs as the catalyst.

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