Heterogeneity of polyclonal IgE characterized by differential charge, affinity to protein A, and antigenicity☆☆☆★★★

Peng, Zhikang; Arthur, Gilbert; Rector, Edward S.; Kierek-Jaszczuk, Danuta; Simons, F.R.; Becker, Allan B.

doi:10.1016/s0091-6749(97)70199-4

Cited by 27 publications

(16 citation statements)

References 28 publications

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“…Another consideration is heterogeneity of IgE, which has been documented in human beings and dogs via numerous techniques. In the sentinel study 19 of dogs, 2 subforms of canine IgE were identified and defined on the basis of differential charge, affinity to protein A, and antigenicity. One of these subforms did not react with a monoclonal anticanine IgE antibody in an ELISA, whereas the other subform was reactive.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of serum obtained from atopic dogs with dermatitis attributable to Malassezia pachydermatis for passive transfer of immediate hypersensitivity to that organism

Morris

DeBoer²

2003

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Section: Discussionmentioning

confidence: 99%

Evaluation of serum obtained from atopic dogs with dermatitis attributable to Malassezia pachydermatis for passive transfer of immediate hypersensitivity to that organism

Morris

DeBoer²

2003

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“…Environmental Th2 and IgE inducers in the tropics are numerous: measles (35), malnutrition (36), filarial parasites (29), insect bites (37,38), and allergens are a few that could thus be suspected to influence the risk of severe malaria. Environmental Th2 and IgE inducers in the tropics are numerous: measles (35), malnutrition (36), filarial parasites (29), insect bites (37,38), and allergens are a few that could thus be suspected to influence the risk of severe malaria.…”

Section: From Immunology To Epidemiologymentioning

confidence: 99%

Interactions between worm infections and malaria

Nacher

2004

Clinic Rev Allerg Immunol

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Helminths are the most prevalent parasitic infections and malaria is the deadliest parasitic disease. Helminths have been reported to be protective against the severe forms of malaria but they were also possibly linked to increased malaria-incidence and gametocyte carriage. Connecting the dots between observations suggests that statistical regularities throughout the evolution of worms and malaria parasites in the same hosts, may have led to the emergence of non-zero interactions as observed in iterated prisoners dilemma games. Thus by protecting the host, helminths protect themselves and their reproductive potential, but also favor the dissemination and reproduction of Plasmodium falciparum. The proximate causes of this evolutionarily stable strategy might be mediated by IgE and the CD23/NO pathway, the protective role of IL10 in helminth-infected patients, and possibly the hematological consequences of worms. The chronic activation of the CD23/NO pathway might be instrumental in downregulating the expression of cytoadherence receptors thus reducing sequestration of parasitized red blood cells in the deep organs. Mild anemia in helminth-infected patients might favor gametocytogenesis and send attractive cues to the vector. This framework leads to numerous testable hypotheses and could explain certain singularities regarding the double edged role of IgE and NO. Among these hypotheses, there are 2 practical ones: the impact of helminths on malaria vaccine candidates, and the theoretical risk of increasing the severity of malaria after anthelmintics. The capacity for increased IgE responses could thus have been vital in our ancestor's wormy and malarious past. Allergies may be what remains of it in the modern world.

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“…Although it is difficult to define the absolute diagnostic sensitivity and specificity of serum IgE antibody assays, because there is no completely reliable reference method for defining sensitivity or specificity to an allergen, most clinical studies compare results of SAT with results of in vivo diagnostic tests (skin tests or inhalation challenge tests) and with case histories of atopic patients. Peng et al 39 reported the existence of IgE subclasses in dogs; monoclonal antibodies could detect 1 subset of IgE but not the other. We are not aware of any published data regarding the specificity or sensitivity for equine IgE of the allergen-specific anti-IgE detection reagents that were used.…”

Section: Discussionmentioning

confidence: 99%

“…2 All 3 SAT evaluated in the study reported here had poor sensitivity. 39 Low sensitivity in SAT could result from differences in concentrations of allergen-specific IgE in the serum and the skin. The low sensitivity may be attributable to lack of ability of these anti-IgE reagents to detect equine IgE.…”

Section: Discussionmentioning

confidence: 99%

Comparison of immediate intradermal test reactivity with serum IgE quantitation by use of a radioallergosorbent test and two ELISA in horses with and without atopy

Lorch¹,

Hillier²,

Kwochka³

et al. 2001

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Heterogeneity of polyclonal IgE characterized by differential charge, affinity to protein A, and antigenicity☆☆☆★★★

Cited by 27 publications

References 28 publications

Evaluation of serum obtained from atopic dogs with dermatitis attributable to Malassezia pachydermatis for passive transfer of immediate hypersensitivity to that organism

Evaluation of serum obtained from atopic dogs with dermatitis attributable to Malassezia pachydermatis for passive transfer of immediate hypersensitivity to that organism

Interactions between worm infections and malaria

Comparison of immediate intradermal test reactivity with serum IgE quantitation by use of a radioallergosorbent test and two ELISA in horses with and without atopy

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