Heterogeneity and selective localisation of T cell clones in human skin and gingival mucosa

Kinane, Denis F.; Karim, Sabeeha Naheed; Garioch, J.; Badri, A T al; Moughal, N. A.; Goudie, R. B.

doi:10.1111/j.1600-0765.1993.tb02112.x

Cited by 13 publications

(8 citation statements)

References 9 publications

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“…Since both mucosa‐homing T cells and neutrophils can adhere to ELAM‐1, Picker et al (1991) suggested that local factors trigger the selection of homing T cells for extravasation to the mucosa. This hypothesis is supported by findings reported by Kinane et al (1993), who used electrophoretic analysis to investigate T‐cell subsets within normal skin and mucosa. They reported that similarities existed in the gene rearrangement profiles of homing T cells when comparing biopsies obtained from symmetric localization in the same individual.…”

Section: Discussionsupporting

confidence: 83%

“…They reported that similarities existed in the gene rearrangement profiles of homing T cells when comparing biopsies obtained from symmetric localization in the same individual. Kinane et al (1993) supposed that a local immune system exists both in the skin and in the mucosa which is composed of skin‐homing and gingiva‐homing memory T cells.…”

Section: Discussionmentioning

confidence: 99%

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Expression of endothelial adhesion molecules in the alveolar ridge mucosa, gingiva and periimplant mucosa

Zitzmann

Berglundh

Marinello

et al. 2002

J Clinic Periodontology

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The results of the present study indicated that the proportions of activated endothelial cells and the extravasation of leukocytes is larger in gingiva and periimplant mucosa than in alveolar ridge mucosa. This might be due to the less permeable keratinized epithelial layer in the edentulous ridge mucosa, which offers proper protection against microbial pathogens. The greater expression of endothelial cell adhesion molecules during experimental gingivitis, compared to periimplant mucositis, may reflect its longer history of repeated antigenic assaults.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Expression of endothelial adhesion molecules in the alveolar ridge mucosa, gingiva and periimplant mucosa

Zitzmann

Berglundh

Marinello

et al. 2002

J Clinic Periodontology

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“…Therefore the distribution of IgA1-and IgA2-producing cells in inflamed gingiva may reflect a difference in the predominant type and nature of antigens involved in the induction of the local humoral immune response in periodontium. The observed preponderance of IgA1 or IgA2 cells in gingival tissues may be due to differences in the original precursors of IgA plasma cells destined for the gingival tissue, selective homing of specific B cells and/or the local expansion of specific B cell clones by various antigens that induce preferential IgA1 or IgA2 responses [52,53].…”

Section: Discussionmentioning

confidence: 99%

IgG and IgA subclass mRNA-bearing plasma cells in periodontitis gingival tissue and immunoglobulin levels in the gingival crevicular fluid

Takahashi

Mooney²,

Frandsen

et al. 1997

Clinical and Experimental Immunology

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SUMMARYThe humoral immune response, especially the production of IgG and IgA, is considered to have a protective role in the pathogenesis of periodontal disease, but the precise mechanisms are still unknown. In order to determine local IgG and IgA production, we investigated the presence of human IgG and IgA subclass mRNA-bearing plasma cells within periodontal tissue by in situ hybridization using digoxigenin-labelled oligonucleotide probes in 24 gingival biopsy samples (pocket depth 5 5 mm) which were obtained from eight patients with adult periodontitis. Furthermore, we examined IgG and IgA subclass proteins and digested IgA1 Fab portions in the gingival crevicular fluid (GCF), corresponding to the sites from which the tissues were taken, by ELISA. IgG and IgA subclass mRNA-expressing cells were detected in all serial formalin-fixed/paraffinembedded gingival tissue sections sampled. Plasma cells showed strong cytoplasmic staining with a high contrast and a good retention of morphology with these probes. IgG1 mRNA-expressing cells were predominant (mean 63%) and IgG2 mRNA-expressing cells were present at around 23% of total IgG plasma cells, while IgG3 and IgG4 mRNA-expressing cells were present to a much lesser extent (3% and 10%, respectively). Similar proportions of IgG subclass proteins in GCF were detected, which were also consistent with 'normal' serum levels. In terms of IgA subclass, IgA1 mRNA-positive cells were predominant (mean 65 . 1%, P

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“…Resistant subjects were proposed to exhibit an increase in TH1 cells selectively homing to the gingiva resulting in B-cell suppression and a stable T-cell lesion with slow tissue destruction. In this regard, Kinane et al (174) used polymerase chain reaction amplification of the V-J junctions of the T-cell receptor y gene rearrangements to establish that T cells localizing in gingiva differ from those in skin and peripheral blood. They concluded that these findings are consistent with the existence of local immune systems composed of skin-homing and gingiva-homing memory T cells.…”

Section: Local Versus Systemic Responsesmentioning

confidence: 99%

Humoral immune response to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in periodontal disease

Kinane¹,

Mooney²,

Ebersole³

1999

Periodontology 2000

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A Elevated in early-onset periodontitis 33,34, 241,271 Leukotoxin (1 15 kDa) Elevated in localized early-onset periodontitis and 31, 211, 333 subset of other early-onset periodontitis 110 kDa Elevated in periodontitis patients 118 64 kDa Elevated in early-onset periodontitis 240 Fimbriae Genetic control of immune response 153 37 kDa Activates pro-inflammatorv mediators 323 29 kDa Less frequent in localized early-onset periodontitis, 347 Heat shock proteins (that is, 64 kDa) 147 elevated in early-onset periodontitis ______ Elevated in diseased Patients Outer membrane antigens 40 and 70 kDa Elevated in generalized early-onset periodontitis 340 80, 65, 58, 31 and 20 kDa Antigenic diversity 92 19, 24, 35 and 67 kDa Present in all sera 340 _~ 39, 34, 28 and 16.5 kDa Antigens present on laboratorv and clinical strains 25 58, 48, 28 and 16-18 kDa Major antigens in human antibody response a4 __ 28,38 and 90 kDa 84 17 kDa Present in all sera 84 Elevated in diseased vs. normal subjects -

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Heterogeneity and selective localisation of T cell clones in human skin and gingival mucosa

Cited by 13 publications

References 9 publications

Expression of endothelial adhesion molecules in the alveolar ridge mucosa, gingiva and periimplant mucosa

Expression of endothelial adhesion molecules in the alveolar ridge mucosa, gingiva and periimplant mucosa

IgG and IgA subclass mRNA-bearing plasma cells in periodontitis gingival tissue and immunoglobulin levels in the gingival crevicular fluid

Humoral immune response to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in periodontal disease

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