Heteroditopic P,N ligands in gold(I) complexes: Synthesis, structure and cytotoxicity

New selective thiolate gold(i) complexes inhibit the proliferation of different human cancer cells and induce apoptosis in primary cultures of mouse colon tumors

“…[9][10][11][12] Application of gold complexes is expanded from their use in rheumatoid arthritis treatment until their employ as antimalarial agents and now in chemotherapy. 13 The most widely known gold complex with pharmacological properties is auranofin, which represents an important milestone in the development of anticancer drugs based on Au(I)-phosphane complexes. [14][15][16][17][18][19][20] Auranofin's structure has served as a model to new gold drugs, where gold(I) center presents two different bonds, one to the S- Phosphorus-and Sulphur-containing nucleophiles are widely used as ligands to enhance the stability of the resulting gold(I) complexes under physiological conditions, that is why the phosphanegold(I) thiolate derivatives constitute a family of very promising experimental agents for cancer treatment.…”

The Important Role of the Nuclearity, Rigidity, and Solubility of Phosphane Ligands in the Biological Activity of Gold(I) Complexes

“…Therefore, interest in medicinal inorganic chemistry has continued to grow with the emergence of gold complexes as alternatives to cisplatin, as many gold(I) and gold(III) compounds exhibit potent tumor cell growth inhibitory properties with much lower toxicity and fewer side‐effects . The recent interest in the biochemistry and bio‐inorganic chemistry of gold has triggered a flood of reports on the potential use of gold complexes for the treatment of a variety of diseases, including rheumatoid arthritis and other chronic inflammatory and auto‐immune diseases, various cancers, as well as bacterial, fungal, and viral infections . Most of these reports focus on gold in either the +I or +III oxidation states, as these forms are comparatively stable in aqueous solution, which facilitates their use in biological research .…”

Synthesis, Characterization, andin vitroCytotoxicity of Gold(I) Complexes of 2-(Diphenylphosphanyl)ethylamine and Dithiocarbamates

“…Previous structural studies on gold(I) complexes with amino/imino‐phosphines reveal that the central gold atoms in these complexes are usually coordinated only by phosphorus atoms adopting a linear environment. The nitrogen atom does not bind to the metal atom , , . Therefore, it is expected that the most probable structures of complex 1 and 2 are those shown in Scheme .…”

“…In recent years, an increasing number of gold(I)‐phosphine complexes have shown to display potent anti‐cancer activities , . However, the reports on cytotoxic properties of gold(I) complexes containing mixed P,N type ligands are limited , . Several mixed ligand gold(I) complexes of phosphines and dithiocarbamates have also been evaluated for the antitumor activity against a number of cells .…”