A new dinuclear cyclic gold(I) complex [Au2(DCyPA)2](PF6)2, 1 based on bis[2-(dicyclohexylphosphano)ethyl]amine (DCyPA) has been synthesized and characterized by elemental analysis, IR and NMR spectroscopies, and X-ray crystallography. In the dinuclear...
Water-soluble gold(i) complexes, [Au(Ipr)(L)]PF6 where L = thiourea (Tu) 1 and N,N′-dimethylthiourea (Me2Tu) 2, were synthesized from the parent 1,3-bis(2,6-di-isopropylphenyl)imidazol-2-ylidenechloridogold(i) [(Ipr)AuCl] (0).
Three novel gold(III) complexes (1–3) of general composition [Au(Bipydc)(S2CNR2)]Cl2 (Bipydc = 2,2′-bipyridine-3,3′-dicarboxylic acid and R = methyl for dimethyldithiocarbamate (DMDTC), ethyl for diethyldithiocarbamate (DEDTC), and benzyl for dibenzyldithiocarbamate (DBDTC)) have been synthesized and characterized by elemental analysis, FTIR and NMR spectroscopic techniques. The spectral results confirmed the presence of both the Bipydc and dithiocarbamate ligands in the complexes. The in vitro cytotoxic studies demonstrated that compounds 1–3 were highly cytotoxic to A549, HeLa, MDA-231, and MCF-7 cancer cells with activities much higher (about 25-fold) than cisplatin. In order to know the possible mode of cell death complex 2, [Au(Bipydc)(DEDTC)]Cl2 was further tested for induction of apoptosis towards the MCF-7 cells. The results indicated that complex 2 induces cell death through apoptosis.
Gold(I) complexes of 2-(diphenylphosphanyl)ethylamine or (2-aminoethyl)diphenylphosphine (AEP), and dithiocaarbamates (R 2 NCS 2 ) were prepared by the reaction of these ligands with (CH 3 ) 2 S-AuCl in dichloromethane. The synthesized complexes [Au(AEP)Cl] (1), [Au(AEP) 2 ]Cl (2), and [Au 2 (R 2 NCS 2 ) 2 ] n (R 2 = dimethyl (3), diethyl (4), and dibenzyl (5)) were characterized by ele-* Dr. A. A. Isab
A new series of seven gold(I) complexes (1–7) containing 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene
(IPr) and phosphane ligands (L1–L7) were synthesized and evaluated
for antitumor activity in ovarian cancer (OvCa) models. The synthesized
complexes were characterized by IR, mass spectrometry and NMR spectroscopy,
and complex 6 was characterized by XRD crystallography.
The antiproliferative effect of the new complexes (1–7) was found to be higher than cisplatin and auranofin in
OvCa cells sensitive and resistant to cisplatin. The anticancer activity
of the most active complex 6 was investigated using OvCa in vitro models, including three-dimensional (3D) multicellular
tumor spheroids and in vivo tumor xenografts. Both
cisplatin and auranofin were used for comparative purposes. Complex 6 induced apoptosis, mitochondrial reactive oxygen species,
and DNA damage; caused a G1 phase cell cycle arrest, inhibited proteasome
activity, and cell migration; modified actin polymerization; and significantly
inhibited OvCa murine xenografts. These promising results suggest
further preclinical testing of these complexes for future applications.
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