Heterocycles 23: Synthesis, characterization and anticancer activity of new hydrazinoselenazole derivatives

Phytochemical Screening and Biological Activity Studies of the Extract from the Bark of <i>Ricinodendron heudoletti</i>, Euphorbiaceae

“…Medicinal plants constitute an important aspect of study for the development of phytomedicine. Studies on traditional medicine has become an important priority of the World health organization since almost 80% of the population in developing economies use medicinal plants as alternative source of treatment of diseases [1,2]. The search for new chemical entities from herbal materials has increase the interest of Cameroonian scientist to exploit the rich cocktail of plant biodiversity for phytochemical screening of potential compounds of pharmaceutical importance and test of activities [3,4].…”

Synthesis of selenoureas and heterocycles based thereon

“…Organoselenium compounds are used as ligands in asymmetric catalysis [10] and promising "green chemistry" catalysts [11]. Selenium-containing organic compounds can be used in cancer therapy [12][13][14][15][16][17][18][19][20][21], in particular as cancer cell proliferation inhibitors [22][23][24][25][26][27][28][29][30][31][32], and they exhibit antihypertensive [33], antibacterial [13,[34][35][36][37][38][39], antifungal [40,41], antiparasitic [42], and antimicrobial activity [43]. During the past decade various selenium derivatives have been tested for biological activity as free radical [44][45][46] and superoxide anion scavengers [47], antioxidants [48][49][50][51][52][53], anti-inflammatory agents, and microglial activation inhibitors [54].…”

Synthesis and in vitro antiproliferative activity of novel benzisoselenazolone derivatives

“…For many years, the organoselenium compounds were synthesized as potential pharmaceuticals, and have become hot spots in the studies of tumor prevention and therapy (He et al, 2012;El-Bayoumy, 1997;Grozav et al, 2013;Zaharia et al, 2013;Terazawa et al, 2010). As an important class of biologically active selenium-containing heterocycles, benzisoselenazolones (BESA) can mimic the features of glutathione peroxidase (GSH-Px) (Wendel and Tiegs, 1986;Parnham and Graf, 1987).…”