The fractions and pure compounds isolated from the bark of R. heudoletti were tested for their antibacterial properties on negative and positive gram bacteria using the disc diffusion method. Phytochemical analysis of the fractions and pure compound isolated was also conducted. The inhibitions parameters of the fractions and pure compound were determined using macro dilution method. The results showed that fraction and isoflavonoid exhibited a significant antibacterial effect against twelve strains isolated from patients. These microorganisms were Gram-negative (Escherichia coli, Salmonella typhi, Shigella flexneri, Pseudomonas aeroginosa, Enterobacter cloacae, Klebsiella pneumoniae, Klebsiella oxytoca, Morganella morganii, Citrobacter freundi, and Proteus vulgaris) and positive gram (Staphylococcus aureus, and Streptococcus feacalis). The ratio of minimal bactericidal concentration (MBC) over the minimal inhibitory concentration (MIC) indicated a promising bactericidal effect of fractions and pure compounds isolated. These results support the current common use of the bark of Ricinodendron heudoletti and flavonoids in the treatment of some infectious diseases.
Our ability to cure common diseases is still in danger due to the creation and spread of bacteria and fungi that are resistant to drugs and has developed new resistance mechanisms. The increasing global expansion of multi- and pan-resistant bacteria commonly referred to as "superbugs," which cause diseases that cannot be treated with current antimicrobial medications like antibiotics, is particularly concerning. Indirect and direct risks to public health are posed by microorganisms that are resistant to antibiotics in food. Food can get contaminated via cross-contamination, intentionally introducing resistance genes during food preparation, and antibiotic-resistant bacteria in food. Consuming unprocessed or unpreserved food products increases the danger of transferring antimicrobial resistance to people and other animals. Stressed cells in food can have an impact on food quality, safety, and security. They can also contribute to the development of resistance and afterwards spread it to unintended organisms in the food chain. These reviews look at a variety of topics to address the question of how antimicrobial resistance mechanisms work. The various types of bacteria that make up infections are examined, as well as the usage of antimicrobial agents and the requirement for alternative antimicrobial agents that will discourage the use of synthetic antimicrobial agents. Additionally, specific details are provided regarding the uniqueness, interdependence, and phylogenicity of organisms as well as their interactions with various ecological media. Thus, it is clear why it is important to work with food producers and handlers to stop the spread of pathogenic organisms.
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