Herpes simplex virus type 2 and Chlamydia trachomatis in adenocarcinoma of the uterine cervix

Zereu, Manuela; Zettler, Cláudio Galleano; Cambruzzi, Eduardo; Zelmanowicz, Alice de Medeiros

doi:10.1016/j.ygyno.2006.11.006

Cited by 21 publications

(19 citation statements)

References 39 publications

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“…On the other hand, Zereu study (Zereu et al, 2007) on etiologic backgrounds and risk factors of cervical adenocarcinoma by routine PCR assay showed that all their tested patients had no HSV-2 contamination. In 2009, Szostek and his colleague study ) on 125 specimens of cervical cancer patients with different levels of neoplasia by PCR and nested PCR showed that none of the studied specimens were infected with HSV-2 viruses.…”

Section: Discussionmentioning

confidence: 99%

Lack of Association between Herpes Simplex Virus Type 2 Infection and Cervical Cancer - Taq Man Realtime PCR Assay Findings

Farivar

Johari²,

Shafei³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Lack of Association between Herpes Simplex Virus Type 2 Infection and Cervical Cancer - Taq Man Realtime PCR Assay Findings

Farivar

Johari²,

Shafei³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…On the other hand, several studies in literature have failed to demon strate significant association between Clamydia and cervical pre neoplasia and cancer [9,13,15,18,19,22,33,68]. Lazenby GB et al, had not found any case of Chlamydia trachomatis using the technique of rRNA detection by TMA [48].…”

Section: B Prevalence Of General Population and In Patients With Ca Ormentioning

confidence: 99%

Association of Genital Infections Other Than Human Papillomavirus with Pre-Invasive and Invasive Cervical Neoplasia

Ghosh

Mandal

Kundu

et al. 2016

JCDR

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“…Because HPV-16 and -18 are the most frequent types associated with SIL and invasive cervical lesions in Brazil, [28][29][30] attention was focused on them, using previously described specific primers and conditions. 31 The absence of amplification by HPV-16 or -18 primers but the presence of amplification by the MY09 and MY11 primers did not exclude the presence of other HPV types, which in this study were designated as HPVX.…”

Section: Hpv Detection and Typingmentioning

confidence: 99%

HLA-G polymorphisms in women with squamous intraepithelial lesions harboring human papillomavirus

et al. 2009

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Human papillomavirus (HPV) infection is etiologically associated with low-(LSIL) and high-grade squamous intraepithelial lesions (HSIL) and with cervical cancer. The progression or regression of the lesions may depend, among other factors, on the host heritable immune response. Because human leukocyte antigen (HLA)-G molecules are involved in the modulation of innate and adaptive immune responses, and because no previous studies have evaluated HLA-G polymorphism in patients with SIL, we conducted a study to assess the association between HLA-G polymorphisms and cervical lesions harboring HPV infection. Cervico-vaginal scrapings and blood samples were collected from 125 women with SIL (68 LSIL and 57 HSIL) and from 94 healthy women without HPV infection and cytological abnormalities. HPV type and HLA-G polymorphisms in exons 2, 3 and 8 (14 bp insertion/deletion) were evaluated by PCR methodology, and digested with restriction endonucleases. The Genepop software and the EM and PHASE algorithms were used for statistical analysis. A significant protective association was observed between the presence of the G*0103 allele and SIL and between the G0101/G0104 genotype and HSIL in the group of patients compared to control. The presence of the G0104/ þ 14 bp and G0104/À14 bp haplotypes conferred susceptibility to SIL compared to control. In addition, patients possessing the G0104/ þ 14 bp haplotype and harboring HPV-16 and -18 co-infections were particularly associated with HSIL. These findings suggest that HLA-G polymorphisms may be associated with HPV infection and SIL, consequently representing a profile of predisposition to cervical cancer.

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Herpes simplex virus type 2 and Chlamydia trachomatis in adenocarcinoma of the uterine cervix

Cited by 21 publications

References 39 publications

Lack of Association between Herpes Simplex Virus Type 2 Infection and Cervical Cancer - Taq Man Realtime PCR Assay Findings

Lack of Association between Herpes Simplex Virus Type 2 Infection and Cervical Cancer - Taq Man Realtime PCR Assay Findings

Association of Genital Infections Other Than Human Papillomavirus with Pre-Invasive and Invasive Cervical Neoplasia

HLA-G polymorphisms in women with squamous intraepithelial lesions harboring human papillomavirus

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