Hermaphroditism induced in the female chick by testicular grafts

Stoll, R; Rashedi, M; Maraud, R

doi:10.1016/0016-6480(80)90033-7

Cited by 26 publications

(16 citation statements)

References 13 publications

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“…Moreover, effects of TAM are seriously decreased in female quail gonads by simultaneous treatment with estrogens as illustrated in Fig. 1 c. Masculinization and intersexuality of the female gonad have been obtained with testicular grafts [48]. In the female hosts, a left ovary or ovotestis and a right atrophic testis and in some cases bilateral atrophic testes were observed.…”

Section: Experimental Modifications Of Female Gonadal Differentiamentioning

confidence: 95%

Effects and Role of Estrogens in Avian Gonadal Differentiation

Scheib

1983

Mechanisms of Gonadal Differentiation in Vertebrates

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Section: Experimental Modifications Of Female Gonadal Differentiamentioning

confidence: 95%

Effects and Role of Estrogens in Avian Gonadal Differentiation

Scheib

1983

Mechanisms of Gonadal Differentiation in Vertebrates

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“…Few (Benhaim et al, 1982). Other investigators (Jost et al, 1972 ;Vigier et al, 1977 ;Stoll et al, 1980 ;Rashedi et al, 1983), struck by the similar timing of ovarian lesions and Mullerian regression, have proposed that both are mediated by the same substance, namely AMH. Using AMH purified by immunochromatography on a monoclonal antibody (Picard and Josso, 1984), we are now in a position to confirm this hypothesis.…”

Section: Introductionmentioning

confidence: 98%

Anti-Müllerian hormone and freemartinism : inhibition of germ cell development and induction of seminiferous cord-like structures in rat fetal ovaries exposed in vitro to purified bovine AMH

Vigier¹,

Watrin²,

Magre³

et al. 1988

Reprod. Nutr. Dévelop.

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Summary. In 13 and 14-day old fetal rat ovaries maintained 3 to 10 days in organ culture, purified bovine anti-Mullerian hormone (AMH) (1.5 to 3 pg/ml) induced a characteristic freemartin effect. Gonadal volume and germ cell number were significantly reduced, compared to control ovaries cultured in anhormonal medium, and epithelial cells with large clear cytoplasm linked by interdigitations differentiated in the gonadal blastema. These cells resembling rat fetal Sertoli cells became polarized and formed seminiferous cord-like structures delineated by a basal membrane containing laminin and fibronectin as is the case of testicular seminiferous cords at the first step of their differentiation. These data indicate that AMH is probably the testicular factor responsible for the morphological modifications of bovine freemartin gonads and suggest that this hormone could also be involved in normal morphological differentiation of the testis. In contrast, in fetal rat ovaries, AMH did not trigger the testosterone production which occurs in freemartin gonads at an early stage of the gestation.Introduction.

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“…Moreover, when our organ cultures were prolonged to a total in ovo and in vitro age of 22-24 days, it was possible to establish the onset of the meiotic prophase in the genetically male germ cells of the induced cortex. A similar phenomenon has also been observed by us (Jordanov and Angelova, 1979) (Jordanov andAngelova, 1974, 1979) or where testes were implanted early in female embryos (Stoll et al, 1978(Stoll et al, , 1980 (Angelova, Jordanov and Kanchev, 1983) demonstrated that chick gonads pretreated in culture with testosterone and having acquired signs of masculinization, enhanced their endogenous production of testosterone above that of estradiol, the T/E 2 ratio being raised above 1, as in a testis. A reverse phenomenon was reported by other researchers (Haffen and C6dard, 1968 ;Teng and Teng, 1977) (Weniger, 1961 ;Grassi-Milano and Pitini, 1977) (Jordanov and Angelova, 1979).…”

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confidence: 48%