Heritability of craniofacial characteristics between parents and offspring estimated from lateral cephalograms

Johannsdottir, Berglind; Thorarinsson, Freyr; Thordarson, Arni; Magnusson, Thordur Eydal

doi:10.1016/j.ajodo.2004.07.033

Cited by 98 publications

(90 citation statements)

References 21 publications

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“…There is no guarantee that variations in shape are captured completely, but quantification of ratios makes it possible to directly quantify differences that a researcher finds through careful observation. This simple technique has been utilized for genetic studies of craniofacial morphology in humans (Savoye et al 1998;Johannsdottir et al 2005) as well as quantification and mapping of wing shape traits in Drosophila (Zimmerman et al 2000). Another more sophisticated approach is known as geometric morphometrics, which reflects the entire diversity of spatial patterns, thus allowing identification of QTL affecting all features in a single analysis (Klingenberg et al 2001(Klingenberg et al , 2004Albertson et al 2003).…”

Section: Discussionmentioning

confidence: 99%

“…The heritability of human craniofacial morphology has been thoroughly investigated in twins and families. A genetic component has been reported for 60-90% of craniofacial traits, including facial height, position of the lower jaw, and cranial base dimensions (Savoye et al 1998;Johannsdottir et al 2005). Further analysis of human linkages is difficult, due in part to sample heterogeneity, limited sample numbers, and a significant impact of environmental factors on craniofacial phenotypes.…”

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confidence: 99%

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Genetic Analysis of Craniofacial Traits in the Medaka

et al. 2007

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Family and twin studies suggest that a substantial genetic component underlies individual differences in craniofacial morphology. In the current study, we quantified 444 craniofacial traits in 100 individuals from two inbred medaka (Oryzias latipes) strains, HNI and Hd-rR. Relative distances between defined landmarks were measured in digital images of the medaka head region. A total of 379 traits differed significantly between the two strains, indicating that many craniofacial traits are controlled by genetic factors. Of these, 89 traits were analyzed via interval mapping of 184 F 2 progeny from an intercross between HNI and Hd-rR. We identified quantitative trait loci for 66 craniofacial traits. The highest logarithm of the odds score was 6.2 for linkage group (LG) 9 and 11. Trait L33, which corresponds to the ratio of head length to head height at eye level, mapped to LG9; trait V15, which corresponds to the ratio of snout length to head width measured behind the eyes, mapped to LG11. Our initial results confirm the potential of the medaka as a model system for the genetic analysis of complex traits such as craniofacial morphology.

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Section: Discussionmentioning

confidence: 99%

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Genetic Analysis of Craniofacial Traits in the Medaka

et al. 2007

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“…23 En esta investigación fueron halladas diferencias estadísticamente significativas en la forma craneofacial al comparar a padres de hijos con LPH con padres de hijos sin HOF, involucrando alteraciones en algunas variables cefalométricas medidas en los planos vertical y transversal. Igualmente, McIntire y Mossey (2002) determinaron que la forma craneofacial de individuos con HOF difiere a la de individuos no afectados y que está influenciada por factores hereditarios.…”

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Evaluación in Vitro De La Percolación Apical Con La Técnica De Cono Único Taperizado Y Condensación Lateral

et al. 2018

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RESUMENObjetivo: Comparar las medidas cefalométricas posteroanteriores (PA) presentes en una población adulta de padres con hijos con labio y/o paladar hendido (LPH) y de padres con hijos sin hendidura orofacial (HOF). Materiales y métodos: Se realizó un estudio observacional descriptivo de corte transversal, se incluyeron 82 padres: 43 padres de niños con LPH no sindrómico y 39 padres de niños sin HOF. Las variables incluidas en este estudio fueron las sociodemográficas y las cefalométricas PA. Se realizó el cálculo de medidas de resumen y para el bivariado se aplicaron la prueba t de Student o el test de rangos de Wilcoxon según la distribución de los datos. Se obtuvieron radiografías PA de los dos grupos con una técnica standard. Luego se les tomaron fotografías con una cámara digital, se exportaron a un computador, con previa calibración y fueron analizadas utilizando el Software Nemoceph. Resultados: Se hallaron diferencias estadísticamente significativas entre padres con y sin labio y/o paladar fisurado en las siguientes variables: Cg-ENA, ENA-Me, Cg-Me, Ag-gA. Igualmente se halló significancia estadística por género frente a la presencia de hijos con o sin HOF en las variables Cg-ENA, ENA-Me, Cg-Me, Ag-gA, Bc-Me. Conclusiones: Algunas medidas cefalométricas posteroanteriores podrían ser diferentes entre la población con y sin LPH, su importancia en el desarrollo de las HOF permitirá evaluar el riesgo de la presencia de esta anomalía en generaciones futuras. COMPARATIVE STUDY OF POSTEROANTERIOR CEPHALOMETRIC MEASURES OF PARENTS OF CHILDREN WITH LIP AND/OR CLEFT PALATE AND PARENTS OF CHILDREN WITHOUT OROFACIAL CLEFTING ABSTRACTObjective: To compare the posteroanterior cephalometric measures (PA) present in parents of children with cleft lip and/ or palate and of parents of children without orofacial clefting (HOF). Materials and methods:A descriptive cross-sectional and observational study was done. Eighty two parents were selected: fourteen-three parents of children with non-syndromic LPH and 39 parents of children without HOF. Sociodemographic variables and PA cephalometric measures were included. The statistical analysis plan implied the calculation of summary measures and T student and rank Wilcoxon test were applied. PA x-rays of the two groups were obtained using a standard technique. Photos were taken using a digital camera, which were then exported to a computer previously calibrated and they were analyzed using the Software Nemoceph.Results: There were statistically significant differences between parents with and without orofacial fissures in the following variables: Cg-ENA, ENA-Me, Cg-Me, Ag-GA. Equally, there was statistical significance for gender in the presence of children with or without HOF in the variable Cg-ENA, ENA-Me, Cg-Me, Ag-GA, Bc-Me. Conclusions: Some PA cephalometric cranio-facial measures can be different between population with and without LPH, its importance in the development of the HOF will allow the evaluation of the risk of the presence of this anomaly in future generations.

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“…(King et al, 1993) Numerous studies have examined how genetic variation contributes to either or both occlusal and skeletal variation among family members. (Arya et al, 1973;Boraas et al, 1988;Byard et al, 1985;Cassidy et al, 1998;Chung & Niswander, 1975;Corruccini et al, 1986;Devor, 1987;Fernex et al, 1967;Gass et al, 2003;Harris et al, 1973;Harris et al, 1975;Harris & Smith, 1980;Harris & Johnson, 1991;Hauspie et al, 1985;Horowitz et al, 1960;Hunter et al, 1970;Johannsdottir et al, 2005;King et al, 1993;Kraus et al, 1959;Litton et al, 1970;Lobb, 1987;Lundstrom & McWilliam, 1987;Manfredi et al, 1997;Nakata et al, 1973;Nikolova, 1996;Proffit, 1986;Saunders et al, 1980;Susanne & Sharma, 1978;Watnick, 1972) In most studies (particularly those that try to account for bias from the effect of shared environmental factors, unequal means, and unequal variances in monozygotic and dizygotic twin samples), (Harris & Potter, 1997) variations in cephalometric skeletal dimensions are associated in general with a moderate to high degree of genetic variation, whereas in general, variation of occlusal relationships has little or no association with genetic variation. (Harris, 2008) Although the heritability estimates are low, most of the studies that looked at occlusal traits found that genetic variation is positively correlated with phenotypic variation for arch width and arch length more than for overjet, overbite, and molar relationship.…”

Section: Heritability and Malocclusionmentioning

confidence: 99%