2012
DOI: 10.1017/thg.2012.59
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Heritability of Ambulatory and Beat-to-Beat Office Blood Pressure in Large Multigenerational Arab Pedigrees: The ‘Oman Family Study’

Abstract: Objective: To estimate the heritability of ambulatory blood pressure (BP), heart rate (HR), and beat-to-beat office BP and HR in an isolated, environmentally and genetically homogeneous Omani Arab population. Methods: Ambulatory BP measurements were recorded in 1,124 subjects with a mean age of 33.8 ± 16.2 years, using the auscultatory mode of the validated Schiller ambulatory BP Monitor. Beat-to-beat BP and HR were recorded by the Task Force Monitor. Heritability was estimated using quantitative genetic analy… Show more

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Cited by 9 publications
(18 citation statements)
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References 23 publications
(43 reference statements)
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“…However, obtaining more than 10 ambulatory BP measures did not substantially increase the heritability estimate [10]. Interestingly, one family study demonstrated that BP heritability was higher when measured several times over 24 h in real-life conditions as opposed to hundreds of readings over a short period in laboratory conditions [9]. In this study, we found no clear advantage to restricting analyses to ambulatory recordings with nearly perfect completeness when studying the genetic determinants of BP.…”
Section: Discussioncontrasting
confidence: 57%
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“…However, obtaining more than 10 ambulatory BP measures did not substantially increase the heritability estimate [10]. Interestingly, one family study demonstrated that BP heritability was higher when measured several times over 24 h in real-life conditions as opposed to hundreds of readings over a short period in laboratory conditions [9]. In this study, we found no clear advantage to restricting analyses to ambulatory recordings with nearly perfect completeness when studying the genetic determinants of BP.…”
Section: Discussioncontrasting
confidence: 57%
“…Bochud et al [10] reported higher heritability estimates only for night-time as compared to daytime DBP, with night-time SBP and PP having similar heritability as daytime BP. In contrast, heritability of daytime BP was found to be higher than night-time BP in a sample of highly consanguineous Omani families [9]. Given these conflicting results, it is questionable whether night-time BP provides an advantage when looking for genetic determinants of BP, especially considering that sleep quality may be differentially affected across members of the same family, thereby adding noise.…”
Section: Discussionmentioning
confidence: 94%
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“…However, heritability estimates for several ambulatory BP values have been shown to be stronger than office values [1][2][3][4][5], an effect attributed in part to averaging larger numbers of BP measurements obtained over a 24-h period [1]. Yet, similar heritability estimates for some office versus ambulatory BP measurements have been reported [1,4,6].…”
Section: Introductionmentioning
confidence: 99%