Heritability of ambulatory and office blood pressure in the Swiss population

Alwan, Heba; Ehret, Georg; Ponte, Belén; Pruijm, Menno; Ackermann, Daniel; Guessous, Idris; Staessen, Jan A.; Asayama, Kei; Kutalik, Zoltán; Vuistiner, Philippe; Paccaud, Fred; Péchère-Bertschi, Antoinette; Mohaupt, Markus; Vogt, Bruno; Martin, Pierre Yves; Burnier, Michel; Bochud, Murielle

doi:10.1097/hjh.0000000000000681

Cited by 14 publications

(10 citation statements)

References 29 publications

(54 reference statements)

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“…It was higher for daytime compared with sleep BP and the heritabilities of office beat-to-beat BP were lower compared with those for ambulatory daytime and 24-h BP measurements. These results were in line with the univariate BP heritability estimates we published previously [ 19 ] and similar to other family studies of ambulatory BP conducted in different populations (SBP: ranging from 0.25 to 0.39; DBP: ranging from 0.20 to 0.41) [ 26 – 29 ]. For example, Fava et al [ 26 ] reported that in 118 Swedish families with 260 siblings (without antihypertensive treatment), heritabilities were significant for ambulatory night-time SBP (37%), DBP (32%), ambulatory daytime SBP (33%), 24-h SBP (30%) and DBP (29%) ( P < 0.05 for all).…”

Section: Discussionsupporting

confidence: 92%

Heritability and genetic correlations of obesity indices with ambulatory and office beat-to-beat blood pressure in the Oman Family Study

Man

Nolte

Jaju

et al. 2020

Journal of Hypertension

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Objective: To more precisely and comprehensively estimate the genetic and environmental correlations between various indices of obesity and BP. Methods: We estimated heritability and genetic correlations of obesity indices with BP in the Oman family study ( n = 1231). Ambulatory and office beat-to-beat BP was measured and mean values for SBP and DBP during daytime, sleep, 24-h and 10 min at rest were calculated. Different indices were used to quantify obesity and fat distribution: BMI, percentage of body fat (%BF), waist circumference and waist-to-height ratio (WHtR). SOLAR software was used to perform univariate and bivariate quantitative genetic analyses adjusting for age, age 2 , sex, age-sex and age 2 -sex interactions. Results: Heritabilities of BP ranged from 30.2 to 38.2% for ambulatory daytime, 16.8–21.4% for sleeping time, 32.1–40.4% for 24-h and 22–24.4% for office beat-to-beat measurements. Heritabilities for obesity indices were 67.8% for BMI, 52.2% for %BF, 37.3% for waist circumference and 37.9% for WHtR. All obesity measures had consistently positive phenotypic correlations with ambulatory and office beat-to-beat SBP and DBP ( r -range: 0.14–0.32). Genetic correlations of obesity indices with SBP and DBP were higher than environmental correlations ( r G : 0.16–0.50; r E : 0.01–0.31). Conclusion: The considerable genetic overlap between a variety of obesity indices and both ambulatory and office beat-to-beat BP highlights the relevance of pleiotropic genes. Future GWAS analyses should discover the specific genes both influencing obesity indices and BP to help unravel their shared genetic background.

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Section: Discussionsupporting

confidence: 92%

Heritability and genetic correlations of obesity indices with ambulatory and office beat-to-beat blood pressure in the Oman Family Study

Man

Nolte

Jaju

et al. 2020

Journal of Hypertension

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“…Risk factors for cardiovascular disease, including insulin sensitivity, blood pressure, lipids, cholesterol, anthropometric measures, and obesity have been shown to have significant heritability . However, the heritability of measures of subclinical atherosclerosis have not been well studied.…”

Section: Introductionmentioning

confidence: 99%

Heritability of Vascular Structure and Function: A Parent–Child Study

Ryder

Pankratz

Dengel

et al. 2017

JAHA

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BackgroundUnderstanding the heritable contribution of vascular measures, from parent to offspring, may aid in risk stratification and atherosclerosis prevention efforts. We hypothesized that measures of vascular structure and function would be heritable in this cohort of parents and their adolescent offspring.Methods and ResultsHigh‐resolution ultrasound scans of the brachial and carotid arteries were obtained in parents (n=558) and their offspring (n=369). Lumen diameter and flow‐mediated dilation were measured in the brachial artery. Intima‐media thickness, lumen diameter, incremental elastic modulus, diameter distensibility, and cross‐sectional distensibility were measured, and carotid cross‐sectional compliance was measured in the carotid artery. Carotid–radial pulse wave velocity was obtained using SphygmoCor®. Heritability analysis (h2, expressed as %) using Sequential Oligogenic Linkage Analysis Routines was performed on the entire cohort and adjusted for age, sex, race, body–mass index, smoking, and mean arterial pressure. Data are presented as mean±SE. Measures of brachial artery diameter (h2=25±9%, P=0.001), lumen diameter (h2=55±9%, P<0.001), intima‐media thickness (h2=29±13%, P=0.014), diameter distensibility (h2=28±7%, P<0.001), cross‐sectional distensibility (h2=27±7%, P<0.001), and pulse wave velocity (h2=26±9%, P<0.001) were significantly heritable. Flow‐mediated dilation and incremental elastic modulus were not significantly heritable. Similar associations were observed in analysis restricted to siblings and complete Trios (mother, father, and child).ConclusionsThese data show that the majority of noninvasive measures of vascular structure and function are heritable, suggesting that measurement of these subclinical risk factors in parents may be helpful in assessing childhood risk for future cardiovascular disease.

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“…Evidence has suggested that the heritability of HTN is around 20–60% [3–5]. Genome-wide association studies (GWASs), especially a recent meta-analysis with large consortia, have been productive in recognition of hypertension susceptibility genes, and more than 200 loci have been identified [6–15].…”

Section: Introductionmentioning

confidence: 99%

An Exploration of Gene-Gene Interactions and Their Effects on Hypertension

Meng

Groth

Quinn

et al. 2017

International Journal of Genomics

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Hypertension tends to perpetuate in families and the heritability of hypertension is estimated to be around 20–60%. So far, the main proportion of this heritability has not been found by single-locus genome-wide association studies. Therefore, the current study explored gene-gene interactions that have the potential to partially fill in the missing heritability. A two-stage discovery-confirmatory analysis was carried out in the Framingham Heart Study cohorts. The first stage was an exhaustive pairwise search performed in 2320 early-onset hypertensive cases with matched normotensive controls from the offspring cohort. Then, identified gene-gene interactions were assessed in an independent set of 694 subjects from the original cohort. Four unique gene-gene interactions were found to be related to hypertension. Three detected genes were recognized by previous studies, and the other 5 loci/genes (MAN1A1, LMO3, NPAP1/SNRPN, DNAL4, and RNA5SP455/KRT8P5) were novel findings, which had no strong main effect on hypertension and could not be easily identified by single-locus genome-wide studies. Also, by including the identified gene-gene interactions, more variance was explained in hypertension. Overall, our study provides evidence that the genome-wide gene-gene interaction analysis has the possibility to identify new susceptibility genes, which can provide more insights into the genetic background of blood pressure regulation.

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Heritability of ambulatory and office blood pressure in the Swiss population

Cited by 14 publications

References 29 publications

Heritability and genetic correlations of obesity indices with ambulatory and office beat-to-beat blood pressure in the Oman Family Study

Heritability and genetic correlations of obesity indices with ambulatory and office beat-to-beat blood pressure in the Oman Family Study

Heritability of Vascular Structure and Function: A Parent–Child Study

An Exploration of Gene-Gene Interactions and Their Effects on Hypertension

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