Herbal Therapy in Dermatology

Bedi, Monica K.; Shenefelt, Philip D.

doi:10.1001/archderm.138.2.232

Cited by 192 publications

(162 citation statements)

References 74 publications

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“…Many cutaneous reactions to herbal preparations and natural products have been reported [33,34] . The most common cutaneous adverse effect is allergic contact dermatitis.…”

Section: Discussionmentioning

confidence: 99%

Topical delivery of silymarin constituents via the skin route

et al. 2009

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Aim: Silibinin (SB), silydianin (SD), and silychristin (SC) are components of silymarin. These compounds can be used to protect the skin from oxidative stress induced by ultraviolet (UV) irradiation and treat it. To this end, the absorption of silymarin constituents via the skin was examined in the present report. Methods: Transport of SB, SD, and SC under the same thermodynamic activity through and into the skin and the effects of pH were studied in vitro using a Franz diffusion assembly. Results: The lipophilicity increased in the order of SC

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“…Many cutaneous reactions to herbal preparations and natural products have been reported [33,34] . The most common cutaneous adverse effect is allergic contact dermatitis.…”

Section: Discussionmentioning

confidence: 99%

Topical delivery of silymarin constituents via the skin route

et al. 2009

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“…This layer isolates the wound site from the environment, reducing the permeability and exudation of the wound (Brown, Dattner, 1998;Bedi, Shenefelt, 2002) and promoting tissue repair. Tannins also exhibit vasoconstrictor and anti-inflammatory properties (Mota et al, 1985;Kapu et al, 2001) and stimulate the growth of epidermis, aiding reepithelialization (Palermo et al, 2002;.…”

Section: Introductionmentioning

confidence: 99%

Wound-healing evaluation of ointment from Stryphnodendron adstringens (barbatimão) in rat skin

Hernandes

Pereira

Palazzo

et al. 2010

Braz. J. Pharm. Sci.

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This study evaluated the cicatrizant effect of an ointment containing 1% of the ethyl-acetate fraction extracted from the stem bark of "barbatimão" (Stryphnodendron adstringens), in wounds made in the skin of rats, after 4, 7 and 10 days of treatment. Control wounds were treated with a base ointment without extract. The proliferation of keratinocytes in the area of reepithelialization was evaluated by counting the number of epithelial cells that were blocked in metaphase by vincristine sulfate. The length of the reepithelialized margin and the contraction of the wound were measured. Topical application of the "barbatimão" ointment stimulated proliferation of the keratinocytes, but had no effect on the length of the epithelium or on the contraction of the wounds. Uniterms:Stryphnodendron adstringens/pharmacognosy. Stryphnodendron adstringens/ cicatrizant effect. "Barbatimão"/pharmacognosy. Wound/healing/experimental study. Reepithelialization.Neste estudo, avaliou-se a atividade cicatrizante de uma pomada contendo uma fração acetato de etila 1% obtida de cascas de "barbatimão" (Stryphnodendron adstringens) em feridas excisionais na pele de ratos após 4, 7 e 10 dias de tratamento. Feridas controle foram tratadas com pomada base, sem extrato. A proliferação dos queratinócitos na área reepitelizada foi avaliada através da contagem do número de queratinócitos bloqueados em metáfase, pelo sulfato de vincristina. O comprimento da margem reepitelizada e a contração das feridas foram mensurados. As feridas tratadas com barbatimão apresentaram um maior número de mitoses do que aquelas tratadas com a pomada base, em todos os tempos avaliados. A aplicação tópica da pomada de "barbatimão" estimulou a proliferação epitelial contudo não teve efeito sobre a migração dos queratinócitos ou sobre a contração das feridas. Unitermos:Stryphnodendron adstringens/farmacognosia. Stryphnodendron adstringens/efeito cicatrizante. "Barbatimão"/farmacognosia. Feridas/cicatrização/estudo experimental. Reepitelização. INTRODUCTIONIn cutaneous lesions, tannins bind to the proteins of the injured tissues, precipitating them (Fernandez et al., 2002) and creating a protective layer (Neto et al., 1996). This layer isolates the wound site from the environment, reducing the permeability and exudation of the wound (Brown, Dattner, 1998;Bedi, Shenefelt, 2002) and promoting tissue repair. Tannins also exhibit vasoconstrictor and anti-inflammatory properties (Mota et al., 1985;Kapu et al., 2001) and stimulate the growth of epidermis, aiding reepithelialization (Palermo et al., 2002;. Reepithelialization involves the proliferation and migration of cells from the edges of the wound, and is regulated by mechanisms involving genes, growth factors, integrins, extracellular matrices (ECM) and metalloproteinases (MMPs) (Santoro, Gaudino, 2005).Stryphnodendron Martius, Leguminosae, popularly known as "barbatimão", is a Brazilian savannah tree. Extracts of the stem bark from species of Stryphnodendron have several medically useful properties, such as antiinflamma...

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“…Besides antioxidant activities, botanical extracts have attracted great interest in the cosmetic and skin care area due to their rich composition and medicinal properties. Matricaria chamomilla L. extract is rich in flavonoids, terpenes, polysaccharides, among others, which may contribute for example anti-inflammatory and emollient effects to the formulations bioactive properties (6,7,8). α-bisabolol, an isolated compound from chamomile extract, has been reported as having antimicrobial (9), anti-inflammatory (10), anti-nociceptive (10), and antimalarial (11) activities.…”

Section: Introductionmentioning

confidence: 99%

“…Além das aticvidades antioxidantes, os extractos botâni-cos têm atraído grande interesse na área de cosméticos e cuidados da pele devido à sua rica composição e às suas propriedades medicinais. O extracto de Matricaria chamomilla L. é rico em flavonoides, terpenos, polissacarídeos, entre outros, que podem fornecer para as formulações propriedades bioactivas, tais como efeitos anti--inflamatório e emoliente (6,7,8). O composto isolado a partir de extracto de camomila α-bisabolol foi avaliado como tendo actividades antimicrobianas (9), anti-inflamatórias (10), anti-nociceptivas (10) e antimaláricas (11).…”

Section: Introductionunclassified

Antioxidant activity of Matricaria chamomilla L. extract and clinical efficacy of cosmetic formulations containing this extract and its isolated compounds

Nóbrega

Wagemaker

Campos

2013

BBR

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249 Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c a Antioxidant activity of Matricaria chamomilla L. extract and clinical efficacy of cosmetic formulations containing this extract and its isolated compounds AbstractTopical application of antioxidants has proven to be effective in protecting the skin against oxidative damage. Matricaria chamomilla L. extract has been used in cosmetic formulations. The aim of this study was to evaluate the antioxidant potential of chamomile extract as well as the clinical efficacy on skin hydration and mechanical properties of skin. The antioxidant activity of chamomile extract was evaluated by chemiluminescence (IC50 = 0.14 μg/mL). Stable formulations were supplemented with 0,5 cg/g α-bisabolol or cg/gwith 5,0 of Matricaria chamomile glycolic extract or with 0,01 cg/g of apigenin and applied on the volar forearm and face of 25 female subjects. Skin physiology was assessed before and after 2 hours (single application) and after a 2-and 4-week period of daily application. After a single application, all formulations increased the stratum corneum water content but only α-bisabolol and chamomile extract formulations reduced TEWL. The formulation with chamomile extract has shown the most pronounced result in the reduction of TEWL (27%). However, after 2-and 4-week application, only the extract formulation increased stratum corneum water content compared with the vehicle. Chamomile extract was effective in neutralizing free radicals and therefore presents an interesting potential in cosmetic formulations for this purpose. Keywords:Chamomile, Clinical Efficacy, Antioxidant Activity, Apigenin, Alpha-Bisabolol, ResumoA aplicação tópica de antioxidantes provou ser eficaz em proteger a pele contra danos oxidativos. O extracto de Matricaria chamomilla L. tem sido amplamente utilizado em formulações cosméticas. Assim, o objectivo deste estudo foi avaliar o potencial antioxidante do extracto de camomila, bem como a eficácia clínica na hidratação e nas propriedades mecânicas da pele. A actividade antioxidante do extracto de camomila foi avaliada por quimioluminescência (IC50 = 0,14 ug / mL). As formulações foram suplementadas com a α -bisabolol de fração mássica 0,5 cg/g ou com extracto glicólico de Matricaria chamomilla L. de fração mássica 5,0 cg/g ou com 0,01 cg/g de apigenina e aplicados na parte interna do antebraço e na cara de 25 mulheres. A fisiologia da pele foi avaliada antes e após 2 horas (aplicação única) e 2 e 4 semanas de aplicação diária. Depois de uma única aplicação, todas as formulações aumentaram a água do estrato córneo, mas apenas as formulações com α -bisabolol e extracto de camomila reduziram a PTEA . A formulação com o extracto de camomila mostrou o resultado mais marcante na redução PTEA (27%). No entanto, após 2 -e 4-semanas de aplicação, apenas a formulação contendo o extracto aumentou o a água no estrato córneo. O extracto de camomila, foi eficaz na neutralização de radicais livres e...

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Herbal Therapy in Dermatology

Cited by 192 publications

References 74 publications

Topical delivery of silymarin constituents via the skin route

Topical delivery of silymarin constituents via the skin route

Wound-healing evaluation of ointment from Stryphnodendron adstringens (barbatimão) in rat skin

Antioxidant activity of Matricaria chamomilla L. extract and clinical efficacy of cosmetic formulations containing this extract and its isolated compounds

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