Antioxidant activity of Matricaria chamomilla L. extract and clinical efficacy of cosmetic formulations containing this extract and its isolated compounds

Nóbrega, Ananda T.; Wagemaker, Tais A. L.; Campos, Patrícia Maria Berardo Gonçalves Maia

doi:10.19277/bbr.10.2.69

Cited by 12 publications

(20 citation statements)

References 21 publications

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“…In vitro antioxidant activity was measured by the chemiluminescence assay 13,14 . Sample solutions (10 ul each) containing CAE or positive control solution at a concentration of 0.1% w/w were mixed with 0.1 M phosphate buffer (pH 7.4), followed by the addition of 2 mg/ mL luminol to yield a final concentration of 1.13 X 10 -4 M. H 2 0 2 was then added to a final 5 X 10 -5 M concentration.…”

Section: Antioxidant Activity Assaymentioning

confidence: 99%

“…A actividade antioxidante in vitro foi medida pelo ensaio de quimioluminescência (13,14) . Uma aliquota de 10 μL das amostras de soluções (concentração final de 0,1%, p/p) contendo CAE ou solução de controlo positivo (sem qualquer substância activa, que produz 100% de produção de radicais livres ) com tampão fosfato 0,1 M (pH 7,4) foram adicionadas a solução de luminol a 2 mg/mL para se obter uma concentração final de 1,13 X 10 -4 M. Adicionou-se H 2 0 2 a uma concentração final de 5 X 10 -5 M. A reacção foi iniciada pela adição de horseadish peroxidase (HRP) a uma concentração final de 0,2 UI/mL e completando o volume final da solução para 1,0 mL.…”

Section: Ensaio De Actividade Antioxidanteunclassified

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Anacardium occidentale L. extract in cosmetic formulations: benefits for oily skin

Mercúrio

Wagemaker²,

Campos³

2017

BBR

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75 Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c a Anacardium occidentale L. extract in cosmetic formulations: benefits for oily skinCashew apple (Anacardium occidentale L.,) extract (CAE) is rich in tannins, flavonoids, amino acids, anacardic acids and vitamin C, which can provide desirable benefits to oily skin. The aim of this study was to assess the antioxidant activity of CAE and the improvement of oily skin after application of a sunscreen containing this extract. The antioxidant activity of CAE was evaluated by chemioluminescence assay. A sunscreen was developed and added (FC), or not (F), with 3.5% of CAE. Transepidermal water loss, stratum corneum water content, sebum content and skin microrelief were evaluated before and after two and four hours of a single application of the F or FC formulations. FC effects on skin were also evaluated after a 28 day-period of twice daily applications on the faces of 12 volunteers. Skin imaging techniques were used to evaluate skin pores and comedones, and sensory analysis was performed. CAE showed antioxidant activity and the FC formulation controlled the sebum secretion after two and four hours. FC reduced the number of skin pores (24%) and did not increase the number of comedones. These results indicate that CAE is an innovative active ingredient from Brazilian biodiversity with antioxidant activity and efficacy to improve oily skin conditions. Keywords:Cashew extract, sunscreen, clinical efficacy, antioxidant activity, cosmetics. ResumoO caju (Annacardium occidentale L, família: Anacardiaceae.) é uma planta nativa da América tropical, e é amplamente cultivada na Ásia e África. Tem grande importância socioeconômica para o Brasil e para diferentes países. O extrato de caju (Anacardium occidentale L.) (CAE) é rico em taninos, flavonoides, aminoácidos, ácidos anacárdicos e vitamina C que podem proporcionar benefícios para a pele oleosa. O objectivo deste estudo foi avaliar a actividade antioxidante do CAE e a melhoradas condições da pele oleosa após aplicação de protetorsolar contendo este extrato. A actividade antioxidante de CAE foi avaliada por ensaio de quimioluminescência. Um protetor solar foi desenvolvido e adicionado (FC) ou não (F) com 3,5% de CAE. A perda transepidérmicade água,o teor de água do estrato córneo, o conteúdo de sebo e o microrrelevo da pele foram avaliados antes e após 2 e 4 horas de uma única aplicação de F e FC; e após um período de 28 dias de aplicações duas vezes ao dia na face de 12 voluntárias. Técnicas de imagem cutânea foram utilizadas para avaliar poros e comedões. A análise sensorial também foi realizada. O CAE mostrou actividade antioxidante. FC controlou a secreção de sebo após 2 e 4 horas, reduziu o número de poros da pele (24%) e não aumentou o número de comedões. O CAE é um ingrediente ativo inovador da biodiversidade brasileira com actividade antioxidante e eficácia para melhorar as condições da pele oleosa.Palavras-chave: Extrato de caju, proteto...

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Section: Antioxidant Activity Assaymentioning

confidence: 99%

Section: Ensaio De Actividade Antioxidanteunclassified

Anacardium occidentale L. extract in cosmetic formulations: benefits for oily skin

Mercúrio

Wagemaker²,

Campos³

2017

BBR

Self Cite

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“…A aprovação para o estudo foi obtida a partir da (5) . Skin microrelief parameters were evaluated using Visioscan ® VC98 and software SELS 2000 from Courage & Khazaka Electronic Gmbh (Cologne, Germany).…”

Section: Protocolo De Estudounclassified

“…The SELS (Surface Evaluation of the Living Skin) method is based on a graphic depiction of the living skin under special illumination, and the electronic processing and evaluation of this image was carried out according to four clinical parameters: a) Skin smoothness (Sesm) -calculated from the average width and depth of the wrinkles, b) Skin roughness (Ser) -the roughness parameter , calculating the gray levels above the threshold in comparison with the entire image (reflects the 'asperity' of the skin. ), c) Wrinkles (Sew) -calculated from the proportion of horizontal and vertical wrinkles and d) Wrinkle depth (Rt) (5) .…”

Section: Protocolo De Estudomentioning

confidence: 99%

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Rheology, clinical efficacy and sensorial of a silicone-based formulation containing pearl extract

Marcon

Wagemaker

Campos

2014

BBR

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247 Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c aRheology, clinical efficacy and sensorial of a silicone-based formulation containing pearl extract Reologia, eficácia AbstractIn traditional Chinese medicine, pearl extract is believed to nourish skin and prevent the aging process. Thus, the aim of this study was to evaluate rheological characteristics, immediate effects on skin, and sensory properties of a silicone-based cosmetic formulation containing pearl extract. Formulations containing pearl extract or not were submitted to physical stability assays by determinations of its rheological behavior during 28 days storage. Once confirmed the formulation's stability, they were applied on the volar forearm of 15 healthy female to evaluate skin properties by non-invasive techniques. After a single application, formulations increased the stratum corneum water content. Once applied on the volar forearm for sensory analysis, the volunteer's majority noted that both formulations improved all the sensory skin attributes, but only the pearl extract formulation has shown the higher scores for all attributes. Results suggested that the silicone-based formulation supplemented with the pearl extract could combine unique sensory properties and effectiveness to better meet consumer's demand. Keywords: Silicone, Pearl Extract, Rheological Behavior, Biophysical Techniques, Sensory AnalysisResumo Na medicina tradicional chinesa, acredita-se que o extracto de pérola pode nutrir a pele e prevenir o processo de envelhecimento. Assim, o objectivo deste estudo foi avaliar as características reológicas, os efeitos imediatos sobre a pele e as propriedades sensoriais de uma formulação cosmética à base de silicone contendo extracto de pérola. As formulações contendo extrato de pérola ou não foram foram submetidas a ensaios de estabilidade física por determinação do comportamento reológico durante 28 dias de armazenamento. Uma vez que as formulações se mostraram estáveis, elas foram aplicadas na região interna do antebraço de 15 indivíduos saudáveis do sexo feminino para avaliar as condições da pele usando técnicas não-invasivas. Após uma única aplicação, as formulações aumentaram o conteúdo de água do estrato córneo. Quando as formulações foram aplicadas no antebraço para a análise sensorial, a maioria dos voluntários notaram que ambas as formulações melhoraram todos os atributos sensoriais da pele, mas que apenas a formulação com extrato de pérola mostrou as maiores notas para todos eles. Os resultados sugerem que a formulação à base de silicone adicionada de extracto de pérolas pode combinar propriedades sensoriais únicas e eficácia para melhor atender a demanda dos consumidores.Palavras-chave: Silicone, Extracto de pérola, Comportamento reológico, Técnicas de biofísica, Análise Sensorial.

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Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity

Jadoon

Karim

Asad

et al. 2015

Oxidative Medicine and Cellular Longevity

125

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The exposure to ultraviolet radiations (UVR) is the key source of skin sunburn; it may produce harmful entities, reactive oxygen species (ROS), leading to aging. The skin can be treated and protected from the injurious effects of ROS by using various pharmaceutical formulations, such as cream. Cream can be loaded with antioxidants to quench ROS leading to photo-protective effects. Moreover, modern medicines depend on ethnobotanicals for protection or treatment of human diseases. This review article summarizes various in vivo antioxidant studies on herbal creams loaded with phyto-extracts. These formulations may serve as cosmeceuticals to protect skin against injurious effects of UVR. The botanicals studied for dermatologic use in cream form include Acacia nilotica, Benincasa hispida, Calendula officinalis, Camellia sinensis, Camellia sinensis, Nelumbo nucifera, Capparis decidua, Castanea sativa, Coffea arabica, Crocus sativus, Emblica officinalis Gaertn, Foeniculum vulgare, Hippophae rhamnoides, Lithospermum erythrorhizon, Malus domestica, Matricaria chamomilla L., Moringa oleifera, Morus alba, Ocimum basilicum, Oryza sativa, Polygonum minus, Punica granatum, Silybum marianum, Tagetes erecta Linn., Terminalia chebula, Trigonella foenum-graecum, and Vitis vinifera. The observed anti-aging effects of cream formulations could be an outcome of a coordinating action of multiple constituents. Of numerous botanicals, the phenolic acids and flavonoids appear effective against UVR-induced damage; however the evidence-based studies for their anti-aging effects are still needed.

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Antioxidant activity of Matricaria chamomilla L. extract and clinical efficacy of cosmetic formulations containing this extract and its isolated compounds

Cited by 12 publications

References 21 publications

Anacardium occidentale L. extract in cosmetic formulations: benefits for oily skin

Anacardium occidentale L. extract in cosmetic formulations: benefits for oily skin

Rheology, clinical efficacy and sensorial of a silicone-based formulation containing pearl extract

Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity

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