Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity

Abstract

The exposure to ultraviolet radiations (UVR) is the key source of skin sunburn; it may produce harmful entities, reactive oxygen species (ROS), leading to aging. The skin can be treated and protected from the injurious effects of ROS by using various pharmaceutical formulations, such as cream. Cream can be loaded with antioxidants to quench ROS leading to photo-protective effects. Moreover, modern medicines depend on ethnobotanicals for protection or treatment of human diseases. This review article summarizes various in vivo antioxidant studies on herbal creams loaded with phyto-extracts. These formulations may serve as cosmeceuticals to protect skin against injurious effects of UVR. The botanicals studied for dermatologic use in cream form include Acacia nilotica, Benincasa hispida, Calendula officinalis, Camellia sinensis, Camellia sinensis, Nelumbo nucifera, Capparis decidua, Castanea sativa, Coffea arabica, Crocus sativus, Emblica officinalis Gaertn, Foeniculum vulgare, Hippophae rhamnoides, Lithospermum erythrorhizon, Malus domestica, Matricaria chamomilla L., Moringa oleifera, Morus alba, Ocimum basilicum, Oryza sativa, Polygonum minus, Punica granatum, Silybum marianum, Tagetes erecta Linn., Terminalia chebula, Trigonella foenum-graecum, and Vitis vinifera. The observed anti-aging effects of cream formulations could be an outcome of a coordinating action of multiple constituents. Of numerous botanicals, the phenolic acids and flavonoids appear effective against UVR-induced damage; however the evidence-based studies for their anti-aging effects are still needed.

The Use of Plants in Skin-Care Products, Cosmetics and Fragrances: Past and Present

“…We already know something about the mechanisms of ROS acting at molecular level on different layers of the skin, and we also understand the chemical structures of a whole series of potent antioxidants [41]. The leaves of green tea (Camellia sinensis (L.) Kuntze) are rich in vitamin C, while the polyphenols of grape seeds (Vitis vinfera L.) inhibit lipid peroxidation [42].…”

Ci̇lt Beyazlaticilara Genel Bakiş

“…Aktif bileşiklerin amaca yönelik jel içinde verilebilirliği dikkate alınarak kullanım avantajı sunması bakımından jel bazlı formülasyonlara da yer verildiği görülmektedir (15,21,22). Yaygın kullanımı olan cilt beyazlatıcı ajanların ilaç veya kozmetik olarak mevcut farmasötik şekil/ preparat türleri aşağıda Tablo 1.`de özetlenmiştir.…”

Health and Beauty Cosmeceuticals Industry and Market Expansion in Saudi Arabia

“…Their application in the treatment of skin diseases, diabetes, and arthritis using advanced research on marine or fauna originated cosmeceutical substances evaluated [19][20][21][22]34,35]. The skincare industry is growing and its contribution for example to the US economy (measured by its industry value added, or IVA) has far outpaced general economic growth and is expected to continue during coming years [22,23,36,37]. Over the 10 years to 2020, IBIS World anticipates IVA to grow at an average annual rate of 8.2%; meanwhile, US GDP is forecast to increase at an annualized 2.5%.…”

“…Over the 10 years to 2020, IBIS World anticipates IVA to grow at an average annual rate of 8.2%; meanwhile, US GDP is forecast to increase at an annualized 2.5%. There is further need of research and development (R&D) investment in cosmeceutical products, coupled with technological advances in order to expand and underpin the cosmeceuticals industry's expansion and opportunities [1,2,37,38].…”

“…Moreover, understanding of local market dynamics, strong local partnership and collaboration, strategic alliances or in-licensing agreements, mutual beneficial joint ventures are active mechanisms for investment and attractive business opportunities [1,2]. Likewise, liaising with big pharmaceutical firms with strong brand equity, advanced technical know-how and capital, R&D capabilities to scale up supply and economy of scale [2,4,30,37,38,41]. The quality of beauty service delivery and outcome of the new generation of biological products activities and beneficial applications is importance.…”