Hepcidin in Obese Children as a Potential Mediator of the Association between Obesity and Iron Deficiency

Giudice, Emanuele Miraglia del; Santoro, Nicola; Amato, Alessandra; Brienza, Carmine; Calabrò, Paolo; Wiegerinck, Erwin T.; Cirillo, Grazia; Tartaglione, Nunzia; Grandone, Anna; Swinkels, Dorine W.; Perrone, Laura

doi:10.1210/jc.2009-1361

Cited by 162 publications

(158 citation statements)

References 39 publications

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“…These results support the data reported in some articles showing that obese patients have higher circulating hepcidin concentrations compared to normal weight subjects and corroborate the idea that the poor iron status frequently observed in obese children may be due to the hepcidin-mediated inhibition of dietary iron absorption. [6][7][8] Recently, in a group of obese women subjected to restrictive bariatric surgery, in agreement with our results, after weight loss, decreased serum hepcidin and improved functional iron status has been shown. 15 We also observed that change in hepcidin concentrations was associated with change in leptin independently of BMI.…”

Section: Discussionsupporting

confidence: 91%

“…8 Interleukin-6 and leptin were measured by commercially available enzyme-linked immunosorbent assay kits. The coefficients of variations within assay were 7% for interleukin-6 and 6% for leptin and between assays were 5% for interleukin-6 and 4% for leptin.…”

Section: Methodsmentioning

confidence: 99%

“…4,5 Three recent studies have shown that, both in obese women and in obese children, serum hepcidin levels were significantly higher compared with normal weight controls and have focused on the hepcidin-mediated inhibition of dietary iron absorption in obese patients. [6][7][8] To gain insight into the link between obesity and hepcidin, we performed an intervention study in a group of obese children and evaluated if body mass index (BMI) decrease may reduce circulating hepcidin levels, increasing, therefore, iron absorption and improving iron status.…”

Section: Introductionmentioning

confidence: 99%

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Effect of body mass index reduction on serum hepcidin levels and iron status in obese children

et al. 2010

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Iron deficiency has been linked to obesity. Hepcidin is the main regulator of iron homeostasis and is higher in obese children compared to controls. To gain insight into the link between obesity and hepcidin, we performed an intervention study in 15 obese children. These children were subjected to a 6-month weight loss program and underwent physical examination and iron status and absorption as well as hepcidin, interleukin-6 and leptin serum levels evaluation at baseline and after the weight loss program. After the program all children reduced their body mass index standard deviation score (BMI SDS) of at least 0.5. We observed a significant decrease in hepcidin (P ¼ 0.003) and leptin levels (P ¼ 0.005), and a significant increase in iron absorption (P ¼ 0.02). A direct correlation between the measure of hepcidin and leptin reduction was observed and this correlation appeared significant (r 2 ¼ 0.33, P ¼ 0.003) when adjusted for interleukin-6 and BMI SDS variations. In conclusion, we have shown that, in obese children, BMI reduction is associated with hepcidin reduction, potentially improving iron status and absorption. Implications of these findings could be considered in the management of obese children with poor iron status.

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of body mass index reduction on serum hepcidin levels and iron status in obese children

et al. 2010

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“…Our findings seem to agree with the observations of Tussing-Humphreys et al [33] who reported that obese premenopausal women have significantly higher serum hepcidin levels compared to nonobese women with similar serum parameters of iron status. Also del Giudice et al [34] and Sanad et al [35], in studies carried out in children aged 7-11 years, observed a significantly higher concentration of hepcidin in the obese. The results suggest that body fat content does have an impact on prohepcidin and hepcidin concentration, and therefore on iron homeostasis.…”

Section: Discussionmentioning

confidence: 90%

Comparison of serum prohepcidin and iron metabolism parameters in obese and non-obese elderly individuals

Przybyszewska

Żekanowska²,

Kędziora–Kornatowska³

et al. 2013

Endokrynologia Polska

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Introduction: Current knowledge indicates that there is a close connection between being overweight, obesity and iron metabolism disorders, but the underlying mechanism is unclear. Hepcidin could be a major contributor to poor iron status observed in the obese population. Material and methods:The study was performed in 58 obese elderly individuals (F/M 34/24) aged 65-91 (78.92 ± 8.32) years. The control group consisted of 15 non-obese elderly volunteers, age-and sex-matched. Based on the WHO definition, 36 (62%) obese individuals were diagnosed with normo-or microcytic anaemia. The following parameters were determined: prohepcidin, haemoglobin, serum iron, erythropoietin, ferritin and C-reactive protein (CRP). Results: Prohepcidin concentrations were significantly increased in obese elderly individuals without anaemia compared to obese and anaemic (p < 0.01) as well as non-obese volunteers (p < 0.01). In obese individuals with anaemia there was a decrease in serum iron, concomitant with increased levels of erythropoietin and CRP compared to two other groups. Ferritin concentration was increased in obese people (with and without anaemia) compared to the non-obese group. Serum prohepcidin levels were positively correlated with fat mass percentage in obese individuals without and with anaemia (r = 0.32; p = 0.02). Conclusion: Results of this preliminary study suggest that body fat content does have an impact on prohepcidin concentration, and thereby on iron homeostasis. (Endokrynol Pol 2013; 64 (4): 272-277)

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“…Estudios in vitro reportaron que la leptina regularía la expresión hepática de Hpc, sugiriendo que el aumento de esta adipoquina en sangre podría contribuir a los desórdenes del metabolismo de Fe 48 . En niños obesos se ha mostrado que el aumento de la producción de Hpc está mediado por la leptina 49 .…”

Section: Obesidad Y Hepcidinaunclassified

Anemia de las enfermedades crónicas asociada a obesidad: papel de la hepcidina como mediador central

2013

Rev. méd. Chile

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Recent evidence suggests that obesity-related inflammation may play a central role in hepcidin regulation. Hepcidin is a key regulator of iron homeostasis and has now been suggested as a central mediator of iron metabolism disorders involved in the pathogenesis of anemia of chronic disease. In this review, we focus on subclinical inflammation in obesity and its effect on hepcidin levels, as the most plausible explanation for the relationship between anemia of chronic disease and obesity.( Rev Med Chile 2013; 141: 887-894).

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Hepcidin in Obese Children as a Potential Mediator of the Association between Obesity and Iron Deficiency

Abstract: We propose that in obese patients, increased hepcidin production, at least partly leptin mediated, represents the missing link between obesity and disrupted iron metabolism.

Cited by 162 publications

References 39 publications

Effect of body mass index reduction on serum hepcidin levels and iron status in obese children

Effect of body mass index reduction on serum hepcidin levels and iron status in obese children

Comparison of serum prohepcidin and iron metabolism parameters in obese and non-obese elderly individuals

Anemia de las enfermedades crónicas asociada a obesidad: papel de la hepcidina como mediador central

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