Comparison of serum prohepcidin and iron metabolism parameters in obese and non-obese elderly individuals

Przybyszewska, Justyna; Żekanowska, Ewa; Kędziora–Kornatowska, Kornelia; Boińska, Joanna; Porzych, Katarzyna; Przybyszewski, Michał; Cichon, R.

doi:10.5603/ep.2013.0005

Cited by 4 publications

(3 citation statements)

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“…Alterations in hepcidin levels have been reported in chronic diseases with iron deposition [4, 5]. There are a growing number of studies targeting the possible role of hepcidin in the pathogenesis of insulin resistance and related diseases [6–8]. Decreased or unchanged hepcidin concentrations have been found in patients with polycystic ovary and metabolic syndrome [9–11].…”

Section: Introductionmentioning

confidence: 99%

GDF-15 and Hepcidin Levels in Nonanemic Patients with Impaired Glucose Tolerance

Yalcin

Altınova

Aktürk

et al. 2016

Journal of Diabetes Research

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Aims. Growth Differentiation Factor-15 (GDF-15) has been suggested as one of the regulators of hepcidin, an important regulatory peptide for iron deposition. Current data is conflicting about the relationship between hepcidin and disorders of glucose metabolism. We aimed to investigate serum hepcidin and GDF-15 concentrations and their associations with each other, in nonanemic subjects with impaired glucose tolerance (IGT) in comparison with the nonanemic subjects with normal glucose tolerance (NGT). Methods. Thirty-seven subjects with IGT and 32 control subjects with NGT, who were age-, gender-, and body mass index- (BMI-) matched, were included in the study. Results. Serum GDF-15 levels were significantly higher in IGT compared to NGT. There were no differences in hepcidin, interleukin-6, and high sensitive C-reactive protein levels between the groups. We found a positive correlation between GDF-15 and hepcidin levels. There were also positive correlations between GDF-15 and age, uric acid, creatinine, and area under the curve for glucose (AUC-G). Hepcidin was correlated positively with ferritin levels. In the multiple regression analysis, GDF-15 concentrations were independently associated with age, uric acid, and AUC-G. Conclusions. Impaired glucose tolerance is associated with increased GDF-15 levels even in the absence of anemia, but the levels of hepcidin are not significantly altered in prediabetic state.

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Section: Introductionmentioning

confidence: 99%

GDF-15 and Hepcidin Levels in Nonanemic Patients with Impaired Glucose Tolerance

Yalcin

Altınova

Aktürk

et al. 2016

Journal of Diabetes Research

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“…Inflammation may perpetuate this condition through the hepcidin-mediated inhibition of iron absorption 7 . A preliminary study suggested that body fat affects prohepcidin concentration and thereby affects iron haemostasis 34 . In childhood, obesity increases hepcidin levels and is associated with a diminished response to oral iron therapy in cases of iron deficiency anaemia 35 …”

Section: Discussionmentioning

confidence: 99%

Iron status and hepcidin levels as potential regulators of haemoglobin homeostasis in overweight and obese women of childbearing age

Insani

Subagio

Hendrianingtyas

2019

Journal of Taibah University Medical Sciences

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ObjectivesOverweight is considered a risk factor for anaemia. However, the mechanisms underlying anaemia development in overweight and obese people remain unclear. This study analysed the correlation of iron status (soluble transferrin receptor [sTfR]/log ferritin ratio) and hepcidin levels with haemoglobin (Hb) levels in overweight and obese women of childbearing age.MethodsIn this cross-sectional study, we recruited 66 women aged 20–29 years with a body mass index ≥23 kg/m2. We gathered data on informed consent, demographic characteristics, questionnaire responses, anthropometric and laboratory values. A Spearman correlation test was performed to determine the correlation.ResultsThe mean levels of ferritin and sTfR were 10.2 ± 8.12 and 22.2 ± 7.96 ng/ml, respectively, and the mean sTfR/log ferritin ratio was 29.3 ± 17.65 nmol/L. The mean hepcidin levels were 9.0 ± 3.05 ng/ml. In total, 75.8% of subjects had low ferritin levels, high sTfR (51.5%) levels, and a high sTfR/log ferritin ratio (87.9%). The sTfR levels (r = −0.359; p = 0.003) and sTfR/log ferritin ratio (r = −0.375; p = 0.002) were negatively correlated with Hb levels. There was no correlation between the levels of hepcidin and Hb (r = −0.140; p = 0.264), but there was a positive correlation between ferritin and Hb levels (r = 0.350; p = 0.004).ConclusionThis study showed a correlation between iron status and Hb levels in overweight and obese women of childbearing age. All the women had erythropoiesis with iron deficiency anaemia. We recommend that overweight and obese women undergo further iron parameters for the detection of early anaemia. In this group, the consumption of foods that enhance iron absorption, such as ascorbic acid, should be encouraged.

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“…In obese subjects hepcidin concentration, produced by adipocytes, is significantly increased. It inhibits the intestinal absorption of iron and its release from macrophages and liver, leading to its accumulation in the body [17]. Therefore, it is suggested that overweight or obese individuals may have higher values of iron status indicators, which may reflect an increased risk of cardiometabolic disorders.…”

Section: Discussionmentioning

confidence: 99%

Association of serum bilirubin, selected iron status indicators and body composition in non-obese, normoglycemic subjects

Bergmann¹,

Bieńkowska²,

Odrowąż-Sypniewska³

2018

Medical Research Journal

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Association of serum bilirubin, selected iron status indicators and body composition in non-obese, normoglycemic subjects ABSTRACT Background: Recently cardiometabolic risk reduction has been observed in patients with slightly elevated bilirubin concentration, as well as increased risk in subjects with excessive iron reserves. The aim of this study was to evaluate the relationship between overweight and/or abdominal obesity, serum bilirubin and selected iron status indicators levels in non-obese subjects. Methods:The study group consisted of 80 healthy, non-obese subjects aged 25-40 years. In all subjects total and direct bilirubin (T-BIL, D-BIL), iron (Fe), transferrin (TRSF), ferritin (FERR) and hepcidin (HEPC) measurements were performed. Anthropometric parameters (BMI, waist circumference, WHR) were measured and body composition (% of body fat, muscles and level of visceral fat) was evaluated using body segment analyzer.Results: Men showed significantly higher values of waist circumference, WHR, muscle mass, visceral fat level and FERR and HEPC concentrations, compared to women. Lower concentrations of T-BIL, D-BIL and higher concentration of FERR, HEPC occurred in the overweight group. In all subjects and in the overweight group T-BIL, D-BIL showed negative correlations with BMI, waist circumference, fat mass and visceral fat level, while for FERR, HEPC those correlations were positive. Overweight subjects had an approximately 4-fold higher incidence of low T-BIL, D-BIL levels (p < 0,001), as well as nearly 2-fold higher incidence of high transferrin level (p = 0,02). Conclusions:Overweight subjects have lower bilirubin levels and higher levels of factors potentially contributing to increased oxidative stress, for example ferritin and hepcidin. Serum bilirubin, ferritin and hepcidin concentration are related to body composition indicators, particullary fat mass and visceral fat level.

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Comparison of serum prohepcidin and iron metabolism parameters in obese and non-obese elderly individuals

Cited by 4 publications

References 40 publications

GDF-15 and Hepcidin Levels in Nonanemic Patients with Impaired Glucose Tolerance

GDF-15 and Hepcidin Levels in Nonanemic Patients with Impaired Glucose Tolerance

Iron status and hepcidin levels as potential regulators of haemoglobin homeostasis in overweight and obese women of childbearing age

Association of serum bilirubin, selected iron status indicators and body composition in non-obese, normoglycemic subjects

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