Hepcidin in anemia of chronic heart failure

Divakaran, Vijay; Mehta, S.; Yao, David; Hassan, Saamir; Simpson, Steven Q.; Wiegerinck, Erwin T.; Swinkels, Dorine W.; Mann, Douglas L.; Afshar-Kharghan, Vahid

doi:10.1002/ajh.21902

Cited by 34 publications

(32 citation statements)

References 26 publications

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“…Decreased serum hepcidin in patients with heart failure and anemia are in line with earlier findings [15,16]. Jankowska et al [8] suggested that the progression of systolic heart failure was associated with a gradual decline in circulating hepcidin and the development of iron-restricted compromised erythropoiesis.…”

Section: Discussionsupporting

confidence: 61%

Growth Differentiation Factor 15 Is Related to Anemia and Iron Metabolism in Heart Allograft Recipients and Patients With Chronic Heart Failure

Przybyłowski

Wasilewski

Bachórzewska−Gajewska

et al. 2014

Transplantation Proceedings

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Section: Discussionsupporting

confidence: 61%

Growth Differentiation Factor 15 Is Related to Anemia and Iron Metabolism in Heart Allograft Recipients and Patients With Chronic Heart Failure

Przybyłowski

Wasilewski

Bachórzewska−Gajewska

et al. 2014

Transplantation Proceedings

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“…107,108 Anaemic HF patients have reduced serum and urine hepcidin compared with non-anaemic and healthy subjects, which is accompanied by depleted total body iron. 107–109 …”

Section: Absolute and Functional Iron Deficiency In Heart Failurementioning

confidence: 99%

Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives

Jankowska

Haehling

Anker

et al. 2012

European Heart Journal

343

377

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Iron is a micronutrient essential for cellular energy and metabolism, necessary for maintaining body homoeostasis. Iron deficiency is an important co-morbidity in patients with heart failure (HF). A major factor in the pathogenesis of anaemia, it is also a separate condition with serious clinical consequences (e.g. impaired exercise capacity) and poor prognosis in HF patients. Experimental evidence suggests that iron therapy in iron-deficient animals may activate molecular pathways that can be cardio-protective. Clinical studies have demonstrated favourable effects of i.v. iron on the functional status, quality of life, and exercise capacity in HF patients. It is hypothesized that i.v. iron supplementation may become a novel therapy in HF patients with iron deficiency.

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“…Anemia of chronic heart failure has been found to be associated with low hepcidin concentrations, making (low-grade) inflammation less likely as the sole underlying mechanism (184,185 ). A study on acute cardiac ischemia showed a transient increase in serum hepcidin-20 concentrations for the majority of patients studied, whereas hepcidin-25 remained increased 7 days after the incident.…”

Section: Disorders Associated With Hepcidin Excessmentioning

confidence: 99%

Hepcidin in Human Iron Disorders: Diagnostic Implications

et al. 2011

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BACKGROUND:The peptide hormone hepcidin plays a central role in regulating dietary iron absorption and body iron distribution. Many human diseases are associated with alterations in hepcidin concentrations. The measurement of hepcidin in biological fluids is therefore a promising tool in the diagnosis and management of medical conditions in which iron metabolism is affected.CONTENT: We describe hepcidin structure, kinetics, function, and regulation. We moreover explore the therapeutic potential for modulating hepcidin expression and the diagnostic potential for hepcidin measurements in clinical practice.

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Hepcidin in anemia of chronic heart failure

Cited by 34 publications

References 26 publications

Growth Differentiation Factor 15 Is Related to Anemia and Iron Metabolism in Heart Allograft Recipients and Patients With Chronic Heart Failure

Growth Differentiation Factor 15 Is Related to Anemia and Iron Metabolism in Heart Allograft Recipients and Patients With Chronic Heart Failure

Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives

Hepcidin in Human Iron Disorders: Diagnostic Implications

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