Hepatoprotective role and antioxidant capacity of pomegranate (Punica granatum) flowers infusion against trichloroacetic acid-exposed in rats

Çelik, İsmail; Temur, Atilla; Isık, Ismail

doi:10.1016/j.fct.2008.10.020

Cited by 114 publications

(65 citation statements)

References 35 publications

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“…According to Celik et al, pomegranate [Punica granatum L. (Lythraceae)] flower extract, or fruit juice improve oxidative stress by preventing lipid peroxidation. In addition, it inhibits the activation of NFκB-mediated signal transductions induced by ROS through antioxidant activity [77]. ROS as well as superoxide and hydroxyl radicals are considered as initiators of free radicals chain reactions of lipid peroxidation.…”

Section: Free Radical Scavengingmentioning

confidence: 99%

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

et al. 2015

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Glycation, the non-enzymatic binding of glucose to free amino groups of an amino acid, yields irreversible heterogeneous compounds known as advanced glycation end products. Those products play a significant role in diabetic complications. In the present article we briefly discuss the contribution of advanced glycation end products to the pathogenesis of diabetic complications, such as atherosclerosis, diabetic retinopathy, nephropathy, neuropathy, and wound healing. Then we mention the various mechanisms by which polyphenols inhibit the formation of advanced glycation end products. Finally, recent supporting documents are presented to clarify the inhibitory effects of polyphenols on the formation of advanced glycation end products. Phytochemicals apply several antiglycation mechanisms, including glucose metabolism, amelioration of oxidative stress, scavenging of dicarbonyl species, and up/down-regulation of gene expression. To utilize polyphenols in order to remedy diabetic complications, we must explore, examine and clarify the action mechanisms of the components of polyphenols.

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Section: Free Radical Scavengingmentioning

confidence: 99%

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

et al. 2015

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“…Hyperglycemia is the initiating event which causes structural and functional changes such as glomerular hyperfiltration, glomerular, and tubular epithelial hypertrophy, and microalbuminuria followed by the development of glomerular basement membrane thickening, accumulation of mesangial matrix, and finally end stage renal disease (Vinod, 2012;Yankunzo et al, 2011). Hyperglycemia is also known to promote oxidative stress and hence involved in the generation of reactive oxygen species (ROS) which play a crucial role in the pathogenesis of diabetic nephropathy (Celik et al, 2009;Luo et al, 2010). Controlling hyperglycemia and improvement of antioxidant capacity will, therefore, prove beneficial in curbing the progression of diabetic nephropathy.…”

Section: Introductionmentioning

confidence: 99%

Flavonoid rich fraction ofPunica granatumimproves early diabetic nephropathy by ameliorating proteinuria and disturbed glucose homeostasis in experimental animals

Ankita

Deepti

Nilam

2014

Pharmaceutical Biology

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Context: Different parts of Punica granatum Linn. (Punicaceae) are traditionally used as renal protective agents in the Indian system of medicine. However, there is paucity of information regarding its role in diabetic nephropathy. Objective: The present study investigates the nephroprotective potential of flavonoid-rich fraction of P. granatum leaves in streptozotocin (STZ)-induced early diabetic nephropathy in experimental animals. Materials and methods: Experimental diabetic nephropathy was induced in Wistar rats by single intraperitonial injection of STZ (65 mg/kg) dissolved in ice cold citrophosphate buffer (pH 4.3). After induction rats were divided into five groups (6 normal; 24 diabetic) and administered with glibenclamide (5 mg/kg) and three dose levels of flavonoid-rich fraction of P. granatum leaves (PGFF), i.e. 50, 100, and 200 mg/kg body weight/day for 28 d. Fasting blood glucose, lipid profile, serum albumin, serum total protein, serum creatinine, blood urea nitrogen (BUN) glycosylated hemoglobin, and biomarkers of kidney oxidative stress were assessed at the end of the treatment period. Urine was analyzed for the measurement of total protein, albumin, and creatinine clearance. Kidney sections were subjected to histopathological study. Results: Daily oral administration of variable dose levels of PGFF for 28 d normalized various biochemical, metabolic, and histopathological changes in the diabetic rats. PGFF significantly (p50.01 and p50.05) improved the glycemic status and renal function in diabetic rats as compared with diabetic control rats. Discussion and conclusion: The results of our study thus prove the protective effect of PGFF in early diabetic nephropathy by ameliorating proteinuria and disturbed glucose homeostasis in experimental animals.

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“…Pomegranate has been known to posses considerable pharmacological properties as pomegranate peel is a rich source of antioxidants, especially polyphenols. In some recent studies, pomegranate fruit and flower extracts exhibited free-radicals scavenging properties with simultaneous potent hepatoprotection against chemically induced liver damage in rodents 10,11 .…”

Section: Introductionmentioning

confidence: 99%

Effect of Punica Granatum (Pomegranate) on serum ALT and AST in Carbon tetrachloride induced liver damage in Wistar Albino Rats

Sadia

Akter

Afroz³

et al. 2016

J Bangladesh Soc Physiol

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Background: Liver diseases are associated with significant morbidity and mortality. Punica granatum may have free radical scavenging activity and it can be used for the prevention and treatment of liver damage. Objective: To observe the hepatoprotective effects of Punica granatum on CCl 4 induced liver damage in rats. Methods: The experimental study was carried out in the Dept of Physiology, Dhaka Medical Ccollege, Dhaka from July 2013 to June 2014. For this purpose, 36 wistar albino rats were studied. After acclimatization for 7 days, they were divided into two groups-control and experimental group. Control group were subdivided into BC (Baseline control), CC (CCl 4 treated control) and SC (Silymarin treated control). Experimental group were subdivided into CP-APT (CCl 4 pretreated and aqueous extract of pomegranate treated), CP-EPT (CCl 4 pretreated and ethanolic extract of pomegranate treated) and APP-CT (Aqueous extract of pomegranate pretreated and CCl 4 treated). Each sub group consisted of 6 rats. All rats received basal diet for 8 days. In addition to basal diet on 8 th day, BC received single dose olive oil and CC received CCl 4 . Rats of SC received silymarin for 8consecutive days . In experimental groups, CP-APT received aqueous extract of Pomegranate and CP-EPT received ethanolic extract of Pomegranate for 8consecutive days. Moreover, APP-CT received aqueous extract of Pomegranate for 8 consecutive days and CCl 4 only on 8 th day. All rats were sacrificed on 9 th day and then blood samples were collected. Serum ALT and AST levels were estimated by using standard laboratory kits. Statistical analysis was done one way ANOVA and Bonferroni test. Results: The mean serum AST and ALT levels were significantly (p<0.001) higher in CC in comparison to those of BC. Serum AST and ALT levels of all experimental groups were significantly (P<0.001) lower than CC. Silymarin used as a standard reference also exhibited significant hepatoprotective activity against CCl 4 induced hepatotoxicity Conclusion: From the result of present study it can be concluded that, Pomegranate may have hepatoprotective effect by lowering ALT and AST levels.

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Hepatoprotective role and antioxidant capacity of pomegranate (Punica granatum) flowers infusion against trichloroacetic acid-exposed in rats

Cited by 114 publications

References 35 publications

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

Flavonoid rich fraction ofPunica granatumimproves early diabetic nephropathy by ameliorating proteinuria and disturbed glucose homeostasis in experimental animals

Effect of Punica Granatum (Pomegranate) on serum ALT and AST in Carbon tetrachloride induced liver damage in Wistar Albino Rats

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