Hepatoprotective evaluation of Anogeissus latifolia: In vitro and in vivo studies

Abstract

AIM:To evaluate the hepatoprotective activity of a hydroalcoholic extract of the bark of Anogeissus latifolia ; in vitro in primary rat hepatocyte monolayer culture and in vivo in the liver of Wistar rats intoxicated by carbon tetrachloride (CCl4). METHODS:In the in vitro study, a primary hepatocyte monolayer culture was treated with CCl4 and extract of Anogeissus latifolia . Hepatoprotective activity was demonstrated in the CCl4 damaged primary monolayer culture. In the in vivo study, the hepatoprotective activity of a hydroalcoholic extract of Anogeissus latifolia was analyzed in liver injured CCl4-treated rats. Biochemical parameters including serum transaminases [aspartate aminotransferase (AST) and alanine aminotransferase (ALT)] and alkaline phosphatase (ALP) in serum were analyzed. The biochemical findings were supplemented with histopathological examination of rat liver sections.

Hepatoprotective and antioxidant activity of a mangrove plant Lumnitzera racemosa

“…The ethanolic leaf extract of L. racemosa posses significant hepatoprotective effect in the CCL 4 intoxicated models (P<0.05). The hepatoprotective effect of the plant extract might be attributed to the presence of unique chemical classes such as alkaloids [16] and polyphenols [17] . The hepatotoxicity effect of the CCL 4 might be due to the formation of the highly reactive free radicals, which directly affects the polyunsaturated fatty acids and directly alters the liver microsaomal membranes in the Wistar albino rats [18] .…”

A comprehensive review on herbal drugs for hepatoprotection of 21stCentury

“…Barbaloin, chrysophanol, glycoside aloe-emodin, glucose, galactose, mannose and galacturonic acid Protects against increased lipid peroxidation and maintained glutathione contents by antioxidant property Amaranthus spinosus [8] Whole plant Ethanol Flavonoids, phenolic, steroids, terpenoids, lipids, saponins Normalises serum biochemical parameter by antioxidant activity Anogeissus latifolia [9] Bark Hydro-alcoholic Tannins, gallic acid, ellagic acid, lutin and quercetin…”

Tribal Way of Livestock Husbandry: An Ethnobotanical Survey of Purulia District, India in Search for Fodder Plants: Neutraceutical and Pharmaceutical Relevance

“…Earlier ethnobotanical excursions were carried out in the area and plants were reported as active against gastrointestinal problems, snake venom and as potential Chaudhary and Sotohy et al (1997) Gastroprotective (Bansal and Goel, 2012), Taparia (1990) antioxidant (Maldini et al, 2011) Ailanthus excelsa Roxb. Kumar (1999) Lavhale and Mishra Gastroprotective (Melanchauski et al, (2007) 2010), antihistaminic (Kumar et al, 2011) Anogeissus latifolia Kumar and Bhatt (2006) NCF Hepatoprotective (Pradeep et al, 2009), (Roxb. ex DC.)…”