A comprehensive review on herbal drugs for hepatoprotection of 21^stCentury

Abstract

Liver is a vital organ that plays a major role in metabolism and excretion of xenobiotics from the body. Liver injury or liver dysfunction is a major health problem that challenges not only health care professionals but also the pharmaceutical industry and drug regulatory agencies. Liver cell injury caused by various toxic chemicals (certain anti-biotics, chemotherapeutic agents, carbon tetrachloride (CCl 4 ), thioacetamide (TAA) etc.), excessive alcohol consumption and microbes is well-studied. The available synthetic drugs to treat liver disorders in this condition also cause further damage to the liver. Hence, herbal drugs have become increasingly popular and their use is wide spread. Herbal medicines have been used in the treatment of liver diseases for a long time. A number of herbal preparations are available in the market. The present review is aimed at compiling data on promising phytochemicals from medicinal plants that have been tested in hepatotoxicity models using modern scientific system.

A Survey of Therapeutic Effects ofArtemisia capillarisin Liver Diseases

“…These limitations have led to the search for alternative remedies among the various herbal formulas. These herbal remedies have existed for a long time and have been useful in the management of hepatic diseases, and A. capillaris is one of the medicinal herbs that are frequently used for liver diseases [ 2 , 3 ].…”

Medicinal plants with hepatoprotective action used by residents in the Varna region (Bulgaria)

“…It is an interesting fact that the locals do not report the use of medicinal plants typical for the Bulgarian flora with proven hepatoprotective properties such as: Anethum graveolens L., Glycyrrhiza glabra L., Hippophae rhamnoides L., Vitis vinifera L., Galium aparine L., Nigella sativa L. (22), and Convolvulus arvensis L. (5). This result shows that the locals do not know and do not use the resources of the area in which they live, and also that they do not rely on the use of medicinal plants as the main means of prevention and therapy.…”

UPLC-ESI-MS/MS and HPTLC Method for Quantitative Estimation of Cytotoxic Glycosides and Aglycone in Bioactivity Guided Fractions of Solanum nigrum L.

“…Plants are well-known traditional medicines which are being used since decades for the management of liver disorders. Thus, treatment of liver diseases with plant-derived compounds seems to be highly attractive because of their accessibility and easy to isolate (Sagar et al, 2014). Herbal medicines have been used to treat liver disorders have now become a promising therapy hence it plays a key role, where 65% of patients in US and Europe depend on herbal preparations for the treatment of liver diseases (Zhang et al, 2013).…”