Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn.

Rao, Guntupalli M. Mohana; Rao, Chandana Venkateswara; Pushpangadan, P.; Shirwaikar, Annie

doi:10.1016/j.jep.2005.08.073

Cited by 183 publications

(107 citation statements)

References 24 publications

(18 reference statements)

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“…The animals were anesthetized using diethyl ether and then sacrificed by decapitation 48 h after the last treatment dose. The blood was immediately collected and the liver samples were dissected (Rao et al, 2006). Each liver sample was then split in two parts.…”

Section: Experimental Protocolmentioning

confidence: 99%

Hepatoprotective and antioxidant activity ofMelaleuca styphelioideson carbon tetrachloride-induced hepatotoxicity in mice

Al‐Sayed

El-Lakkany

el-Din

et al. 2014

Pharmaceutical Biology

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Context: Liver disease is a serious problem. Polyphenolic compounds have marked antioxidant effect and can prevent the liver damage caused by free radicals. In vitro studies have revealed the strong antioxidant activity of an ellagitannin-rich plant, namely, Melaleuca styphelioides Sm. (Myrtaceae). Objective: In view of the limited therapeutic options available for the treatment of liver diseases, the hepatoprotective potential of the methanol extract of M. styphelioides leaves (MSE) was investigated against CCl 4 -induced liver injury in mice. Materials and methods: MSE was administered (500 and 1000 mg/kg/d p.o.) along with CCl 4 for 6 weeks. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were determined in the serum. Glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione transferase (GST), and malondialdehyde (MDA) were estimated in the liver homogenate. The bioactive components of MSE were identified by NMR, UV and HRESI-MS/MS data. Results: MSE treatment (500 and 1000 mg/kg/d) markedly inhibited the CCl 4 -induced increase in the levels of AST (31 and 38%), ALT (29 and 32%), ALP (13 and 19%), and MDA (22 and 37%) at the tested doses, respectively. MSE treatment markedly increased the levels of GSH (29 and 57%) and antioxidant enzymes compared with the CCl 4 -treated group. MSE was more effective than silymarin in restoring the liver architecture and reducing the fatty changes, central vein congestion, Kupffer cell hyperplasia, inflammatory infiltration, and necrosis induced by CCl 4 . The LD 50 of MSE was more than 5000 mg/kg. Conclusion: MSE confers potent antioxidant and hepatoprotective effects against CCl 4 -induced toxicity.

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Section: Experimental Protocolmentioning

confidence: 99%

Hepatoprotective and antioxidant activity ofMelaleuca styphelioideson carbon tetrachloride-induced hepatotoxicity in mice

Al‐Sayed

El-Lakkany

el-Din

et al. 2014

Pharmaceutical Biology

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“…A root extract is hepatoprotective (Rao et al 2006) and useful for disintegration and elimination of urinary stones (Mischenko et al 1999). It is anti-proliferative against epidermal keratinocytes (Tse et al 2006).…”

Section: Indian Madder (E)mentioning

confidence: 99%

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Kunwar

Uprety

Burlakoti

et al. 2009

Ethnobot. Res. App.

304

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Ethnopharmacological knowledge is common and import among tribal populations but much of the information is empirical at best lacking scientific validation. Despite widespread use of plant resources in traditional medicines, bioassay analysis of very few plant species have been conducted to investigate their medicinal properties, and to ascertain safety and efficacy of traditional remedies. The present study analyses indigenous uses of medicinal plants of far-west Nepal and compares with earlier ayurveda studies, phytochemical assessments and pharmacological actions. A field study was carried out in Baitadi and Darchula districts of far-west Nepal. Group discussions, informal meetings, questionnaire surveys and field observations were employed for primary data collection. Voucher specimens were collected with field notes and codes and deposited at Tribhuvan University Central Herbarium (TUCH), Kathmandu. Only 50% of species surveyed shared common uses with ayurvedic medicine. This implies that these herbal remedies are part of an independent health care system in the Nepal Himalaya, which is indigenous and influenced by ayurveda. The folk uses of some of the species were contradicting to those of ayurveda and phytochemical bioassays. A detailed phytochemical study on those species would be an important line of research. IntroductionMedicinal plants help in alleviating human suffering and are widely used for subsistence, home remedies, and trade (Kunwar et al. 2006). It is estimated that 70-80% of people worldwide rely on traditional herbal medicine to meet their primary health care needs (Farnsworth & Soejarto 1991). The ayurveda is an ancient traditional system of medicine with remedies for health and alleviation of illness. The acceptance of the ayurveda is gearing up and use of indigenous drugs of natural/plant origin is a maPublished: January 16, 2009 Ethnobotany Research & Applications 6www.ethnobotanyjournal.org/vol7/i1547-3465-07-005.pdf cuna pruriens (L.) DC. for Parkinson's disease, Commiphora as a hypolipidemic, Asclepias as cardiotonic, psoralens for vitiligo, curcumines for inflammation, baccoside for mental retention, picrosides for hepatoprotective, diosgenin for the synthesis of steroidal hormones, guggulsterons as hypolipidemic, piperidine as bioavailability enhancers, asarone as hallucinogenic, phyllanthins as anti-virals, withanolides and many other steroidal lactones and their glycosides as immunomodulators (Jain 1994, Patwardhan 2000. As an example, the sale of drugs derived from the plant Taxus The increasing use of traditional therapies demands more scientifically sound evidence for the principles behind therapies and for effectiveness of medicines (Patwardhan et al. 2005). The therapies are often criticized due to dearth of research, critical evaluation, in vivo studies and validations (Fong 2002, Houghton 1995 to support the safety of uses. At the same time, ethnopharmacological knowledge is percolating down these days among the tribal population. The present study, therefore aim...

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“…Herbal drugs play a major role in the treatment of hepatic disorders. A number of medicinal plants and their formulations are used to cure hepatic disorders in traditional systems of medicine [4]. In addition to these known plants, there are unexplored group of plants used by tribal and folk medical practitioners which are a promising source of effective hepatoprotective agents [5].…”

Section: Introductionmentioning

confidence: 99%

Attenuation of Biochemical Parameters in Streptozotocin-induced Diabetic Rats by Oral Administration of Extracts and Fractions of <i>Cephalotaxus sinensis</i>

Saeed

Deng

Dai

2008

J. Clin. Biochem. Nutr.

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Summary Cephalotaxus sinensis (C. sinensis) large size, evergreen tree common in China and utilized for numerous effective pharmacological applications in Chinese traditional medicine. The hepato-renal effects of C. sinensis were evaluated in vivo using Streptozotocin (STZ)-induced diabetic rats as an tentative model. Animals were orally treated with 80% EtOH extract (aq.EE), H2O extract (WtE) and ethylacetate (EaF)/butanol fractions (BtF) of C. sinensis (200 mg/kg, b.w.) for 28 days whereas control received vehicle merely. The degree of fortification was measured by using biochemical parameters like serum transaminases (ALT and AST), alkaline phosphatase (ALP), creatinine, urea and urine sugar. Meanwhile, the histopathological studies were conducted out to support the above parameters. Administration of C. sinensis aq.EE/BtF (p<0.05) and EaF (p<0.01) patently prevented STZ-induced elevation levels of serum ALT, AST, ALP, creatinine, urea, urine sugar and increase body weight respectively, which were comparable with the standard drug tolbutamide, while WtE did not show any significant effect (p>0.05). Phytochemical studies revealed the presence of saponins, terpenes, sterols and flavonoids in C. sinensis which could be responsible for the possible hepato-renal protective action. The results sustain the fact that the extract/fractions of C. sinensis have an immense potential to be developed further into a phytomedicine.

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Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn.

Cited by 183 publications

References 24 publications

Hepatoprotective and antioxidant activity ofMelaleuca styphelioideson carbon tetrachloride-induced hepatotoxicity in mice

Hepatoprotective and antioxidant activity ofMelaleuca styphelioideson carbon tetrachloride-induced hepatotoxicity in mice

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Attenuation of Biochemical Parameters in Streptozotocin-induced Diabetic Rats by Oral Administration of Extracts and Fractions of <i>Cephalotaxus sinensis</i>

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