Attenuation of Biochemical Parameters in Streptozotocin-induced Diabetic Rats by Oral Administration of Extracts and Fractions of &lt;i&gt;Cephalotaxus sinensis&lt;/i&gt;

Saeed, Muhammad; Deng, Yulin; Dai, Rongji

doi:10.3164/jcbn.2008004

Cited by 49 publications

(44 citation statements)

References 34 publications

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“…These results come in accordance with the previous findings (Abubakar et al, 2009) demonstrated that diabetes induction caused insignificant changes in serum levels of ALT, AST, urea and creatinine. In the contrary, the present findings also disagree with others (Saeed et al, 2008) demonstrated an increase in blood urea nitrogen and uric acid in STZ induced diabetic rats indicated kidney dysfunction.…”

Section: Tablecontrasting

confidence: 56%

“…However, this difference perhaps attributed to different species, dose and experimental period. The increased activity of AST in STZ induced diabetic rats indicated liver dysfunction as reported before in rats (Saeed et al, 2008). Liver damage was observed after oral administration of aqueous extract of Nigella sativa (10 ml/kg of body weight for 14 consecutive days) in rats (Tennekoon et al, 1991) or in mice after oral administration of an aqueous extract of the Black cumin seeds in 4 different doses, 6, 9, 14 and 21 g/kg (Vahdati-Mashhadian et al, 2005).…”

Section: Tablementioning

confidence: 86%

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Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats

El-Bahr¹,

Taha²,

Korshom³

et al. 2014

AJVS

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Key wordsABSTRACT: Diabetes mellitus, blood glucose, body weight, water intake, food intake.The objective of the present study was to investigate the effect of Turmeric (Curcuma Longa) and Black cumin seed (Nigella Sativa) mixture on selected biochemical parameters of streptozotocin (STZ) induced diabetic rats. Therefore, twenty one healthy adult albino rats divided into three groups (7 rats in each). Rats of first and second groups were non diabetic and diabetic respectively. Rats of the third group were diabetic and received a mixture of Turmeric (0.5 g/kg b .wt.) and Black cumin seed (1 g/kg b.wt.) orally by intragastric intubations once a day for six weeks. The changes in blood glucose level, body weight and water and food intake were measured. In addition, selected biochemical parameters were also determined. The present study revealed that, dietary supplementation of plant mixture of Turmeric and Black cumin seed to diabetic rats significantly (P<0.05) reduced the blood glucose level as well as water and food intake accompanied by an increase in body weight gain when compared with untreated diabetic rats. Proteins were not affected whereas liver and kidney functions were disrupted in STZ-diabetic rats and restored whenever treated by medicinal plants mixture. Hypercholesterolemia and hyperlipidemia observed in STZdiabetic rats were attenuated by administration of examined medicinal plants combination. Conclusively, dietary supplementation of Turmeric and Black cumin seed mixture reduced blood glucose level and ameliorated the hypercholesterolemia and hyperlipidemia in STZ induced diabetic rats.

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Section: Tablecontrasting

confidence: 56%

Section: Tablementioning

confidence: 86%

Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats

El-Bahr¹,

Taha²,

Korshom³

et al. 2014

AJVS

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“…One of the most sensitive and dramatic indicators of kidney injury is an increase in serum creatinine (52) . Conversely, pre-treatment with the extract signifi cantly reduced the creatinine level in CCL4 treated rats.…”

Section: Groupsmentioning

confidence: 99%

Hepatoprotective and in vivo antioxidant activities of ethanolic extract of whole fruit of Lagenaria breviflora

Saba

Onakoya²,

Oyagbemi³

2012

JBCPP

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“…Animals were housed in poly ethylene cages at temperature [21][22][23][24][25] 0 C, 12 h light/dark cycle and relative air humidity 40-45%. Rats fed at libido with the standard food and tap water.…”

Section: Animals and Experimental Protocolmentioning

confidence: 99%

Evaluation of hypoglycemic and hypolipidemic effects of internal septum of walnut fruit in alloxan-induced diabetic rats

Ghiravani¹,

Hosseini²,

Taheri³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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Background: Todays, the popularity of herbal medicine is increasing worldwide. Due to importance the evaluation of medicinal herbs efficacy and safety, the present study was conducted to investigate the antidiabetic and hypolipidemic effects of internal septum of walnut fruit (ISWF) ethanolic extract in diabetic rats. Materials and methods: Alloxan diabetic rats treated orally with ethanolic extract of ISWF (0-400mg/kg) for 28 days. To evaluate its anti-diabetic activity, the animals fasting blood glucose were determined on the first, 14 th and 29 th days. Moreover, oral glucose tolerance test (OGTT) was performed in diabetic rats at the last day of the study. After 24h of last administration, the blood samples were collected, and the Plasma lipids and liver enzymes levels were measured in fasting overnight rats. Results: The extract significantly decreased blood glucose (p<0.001) on 14 th and 29 th days. In addition, OGTT revealed that the hypoglycemic effect of the extract appeared at 90 minutes. Alanine aminotransferase and aspartate aminotransferase levels significantly decreased in diabetic rats treated with the both doses (p<0.05). Both doses of the extract were able to decrease triglyceride significantly (p<0.05) in treated diabetic rats, while only the lower dose of the extract (200 mg/kg) attenuate the total cholesterol and low density lipoprotein (p<0.001). Conclusion: These finding support the notion that ISWF is able to reduce hyperglycemia and hyperlipidemia risk in diabetic rats. Key words:Juglans regia, internal septum, walnut fruit, Antidiabetic, Lipid profile IntroductionDiabetes mellitus is a chronic metabolic disease characterized by hyperglycemia due to the impaired secretion and/or action of insulin (Chikhi et al., 2014). Its prevalence is increasing in many populations all over the world. In 2011, there were 366 million cases with diabetes, and it is expected to increase up to 522 million by 2030(Whiting et al., 2011. Hyperglycemia leads to alteration in metabolism of carbohydrate, protein and fat (Wan et al., 2013). This condition results in long term pathogenic disorders such as neuropathy, retinopathy and nephropathy and consequently lowering in life quality (Santaguida et al., 2005). Currently, multiple pharmacological interventions including sulphonylureas, biguanides, alpha-glucosidase inhibitors, thiazolidinediones and/or insulin are applied for the treatment of diabetes (Grossman et al., 2013). However, all of these medications have limited efficacy and result in various side effects such as gastrointestinal upset, weight changes, hypoglycemia, joint stiffness, kidney and skin complications (Nathan, 2007;Soccio et al., 2014).Complementary and alternative medicine has been often used for treatment of diabetes. The most widely used therapies in diabetic populations are nutritional supplements and herbal; people with diabetes use these therapies concurrently with conventional health care services (Chang et al., 2007).The fruit of Juglans regia L (family; Juglandaceae) is a valu...

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Attenuation of Biochemical Parameters in Streptozotocin-induced Diabetic Rats by Oral Administration of Extracts and Fractions of <i>Cephalotaxus sinensis</i>

Cited by 49 publications

References 34 publications

Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats

Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats

Hepatoprotective and in vivo antioxidant activities of ethanolic extract of whole fruit of Lagenaria breviflora

Evaluation of hypoglycemic and hypolipidemic effects of internal septum of walnut fruit in alloxan-induced diabetic rats

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