Hepatoprotective and in vivo antioxidant activities of ethanolic extract of whole fruit of <i>Lagenaria breviflora</i>

Saba, Adebowale Benard; Onakoya, Omowumi M; Oyagbemi, Ademola Adetokunbo

doi:10.1515/jbcpp-2011-0034

Cited by 15 publications

(9 citation statements)

References 26 publications

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“…CCl 4 proved to be highly useful as an experimental model for the study of liver damage in humans 33 34 35 . It is usually used through intraperitoneal injection or oral administration, and with a dosage of 0.2 to 5 ml/kg liver fibrosis is achieved between 4 and 18 weeks 36 37 . In this study, the mild, medium and severe liver fibrosis rat models were developed through differential doses (25–62.5%) and exposure duration (10–15 weeks) of CCl 4 .…”

Section: Discussionmentioning

confidence: 99%

The Effect of rhCygb on CCl4-Induced Hepatic Fibrogenesis in Rat

Wei

Chen

et al. 2016

Sci Rep

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This study aims to investigate whether the use of recombinant human cytoglobin (rhCygb) impact on hepatic fibrogenesis caused by CCl4. SD (n = 150) rats were randomly divided into three groups of normal, CCl4 model and rhCygb groups. After model establishment, rats in rhCygb groups were administered daily with rhCygb (2 mg/kg, s.c.). Histological lesions were staged according to metavir. Serum parameters including ALT, AST, HA, LN, Col III and Col IV were determined. The liver proteins were separated by 2-DE and identified. As a result, the stage of hepatic damage and liver fibrosis in rhCygb groups were significantly milder than that in CCl4 model groups. Meanwhile, rhCygb dramatically reversed serum levels of ALT and AST, and also markedly decreased the liver fibrosis markers levels of LN, HA, Col III and Col IV. In 2-DE, 33 proteins among three groups with the same changing tendency in normal and rhCygb treated groups compared with CCl4 model group were identified. GO analysis showed that several identified proteins involved in oxidative stress pathway. The study provides new insights and data for administration of rhCygb reversing CCl4-induced liver fibrosis suggesting that rhCygb might be used in the treatment of liver fibrosis.

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Section: Discussionmentioning

confidence: 99%

The Effect of rhCygb on CCl4-Induced Hepatic Fibrogenesis in Rat

Wei

Chen

et al. 2016

Sci Rep

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“…Indeed, APAP overdose depletes glutathione levels and generates free radicals (Jaeschke and Bajt, 2006). Potent antioxidants and several medicinal plants extracts already used to treat liver diseases prevent APAP induced hepatotoxicity (Fahim et al, 1999;Sotelo-Felix et al, 2002a), which have also been used in the treatment of liver diseases Saba et al, 2012;Singhal and Gupta., 2012;Liu et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effect of Rosmarinus officinalis and rosmarinic acid on acetaminophen-induced liver damage

Lucarini

Bernardes

Tozatti

et al. 2014

Emir. J. Food Agric

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The hydroalcoholic extract of the leaves of Rosmarinus officinalis (HE), a species of medicinal value, and its constituent rosmarinic acid (RA) were evaluated for hepatoprotective in the acetaminophen-induced liver damage model. Groups of Wistar albino rats (n=6) were pre-administered with HE (100, 250 and 500 mg/kg, p.o.) and RA (10, 25 and 50 mg/kg, p.o.) prior to a single dose of acetaminophen (APAP, 600 mg/kg body weight; p.o). The hepatoprotective activity of HE extract was observed through histopathological analysis and reduction of the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP). These observations were comparable to the normal group prior to APAP administration. Group that was treated with APAP alone exhibited high levels of transaminases and ALP. The obtained results from the present study suggested that HE may prevent APAP-induced hepatic injuries. RA did not displayed significant hepatoprotective activity against APAP-induced liver damage.

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“…25 Heavy metals have hepatotoxic potential due to production of oxidative stress to the tissue, lagenaria siceraria has remarkable oxidative capability and is in a position to reverse the oxidative stress and concomitantly can minimize the inflammation in the interstitium and area of portal triads. 26,27 Lagenaria siceraria on biochemical evaluation was found to have flavonoids. Plants which have flavonoids have an impact on arachidonic acid metabolism and are thought to have antiinflammatory, cardio protective and anti-allergic effects 28,29 Present study also revealed that when lagenaria siceraria was simultaneously given to the animals who were exposed to heavy metal toxicity the process of inflammation and fibrosis was reverted (Table-I&II).…”

Section: Discussionmentioning

confidence: 96%

Lagenaria Siceraria;

Qureshi

Qamar

Hussain³

2019

TPMJ

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Objectives: To observe the effect of lagenaria siceraria on inflammation and fibrosis brought about by arsenic in liver of Sprague Dawley rat. Study Design: Laboratory based randomized control trial. Place and Duration of Study: This experiment was performed at Department of Anatomy, Army Medical College Rawalpindi in co-operation with National Institute of Health (NIH) Islamabad for eight weeks (1st March 2017 to 25th April 2017). Material and Methods: Fifty Sprague Dawley rats (both male and females housed separately) were carefully chosen and distributed randomly into five groups, each consisting of 10 animals. A and B were the control groups whereas C, D and E served as experimental groups. During the first four weeks, experiment groups C, D and E were given a dosage of 5milligram/kilogram body weight of sodium arsenite. At the end of four weeks, animals from control group A and experimental group C were dissected and liver samples were processed for microscopic studies. In the next 4 weeks, group D animals were set aside without any further intervention. At that time, sodium arsenite at a dose of 5 milligram/kilogram body weight and lagenaria siceraria at a dose of 100 milligram/kilogram bodyweight were administered to group E animals. Group B animals served as control for experimental groups D and E. At the end of these 4 weeks animals of groups B, D and E were dissected. Liver was processed, fixed and stained for microscopic study. Area of portal triad as well as liver lobules were studied for inflammation and fibrosis and results were analysed. Statistical tool used to analyse the data was SPSS v 22. Results were considered to be significant when p-value is ≤ 0.05. Results: Experimental group C developed moderate grade fibrosis and inflammation (grade 2 to 3) as compared to group A. Degree of inflammation and fibrosis was mild to moderate (grade 1 to 2) in group D. There was no inflammation and fibrosis (Grade 0 to 1) in group E. Group B served as a control for group D and E. Conclusion: Inflammation and fibrosis developed in the liver of adult rats when they were subjected to sodium arsenite even for a brief calculated period. Simultaneous administration of lagenaria siceraria can shield and diminish the toxic effects of arsenic. Oxidative potential and immunomodulatory properties and presence of flavonoid like substances renders lagenaria siceraria to act as ameliorative against this fibrosis and inflammation in liver lobules and surrounding area of portal triads.

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Hepatoprotective and in vivo antioxidant activities of ethanolic extract of whole fruit of Lagenaria breviflora

Abstract: The present study suggested that treatment with LB extract enhances the recovery from CCL4 induced hepatic damage and oxidative stress via its antioxidant and hepatoprotective properties.

Cited by 15 publications

References 26 publications

The Effect of rhCygb on CCl4-Induced Hepatic Fibrogenesis in Rat

The Effect of rhCygb on CCl4-Induced Hepatic Fibrogenesis in Rat

Hepatoprotective effect of Rosmarinus officinalis and rosmarinic acid on acetaminophen-induced liver damage

Lagenaria Siceraria;

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