Hepatoprotective effects of Pittosporum neelgherrense Wight&amp;Arn., a popular Indian ethnomedicine

Shyamal, S.; Latha, P. G.; Shine, V.J.; Suja, S. R.; Rajasekharan, S.; Devi, T. Ganga

doi:10.1016/j.jep.2006.02.018

Cited by 28 publications

(17 citation statements)

References 9 publications

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“…The largest pool of ALT is found in cytosol of hepatic parenchymal cells (Okuda, 1997). AST is found in cytosol and mitochondria of hepatocytes and also found in cardiac muscle, skeletal muscle, pancreas and kidney (Shyamal et al, 2006). Therefore, measurement of ALT is more liver specific to determine hepatocellular damage (Shyamal et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…AST is found in cytosol and mitochondria of hepatocytes and also found in cardiac muscle, skeletal muscle, pancreas and kidney (Shyamal et al, 2006). Therefore, measurement of ALT is more liver specific to determine hepatocellular damage (Shyamal et al, 2006). Nevertheless, AST is still being commonly used as a laboratory test to assess liver function since it is considered to be a sensitive indicator of mitochondria damage particularly in the centrilobular regions of liver (Panteghini, 1990).…”

Section: Discussionmentioning

confidence: 99%

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Chemopreventive Efficacy of Moringa oleifera Pods Against 7, 12-Dimethylbenz[a]anthracene Induced Hepatic Carcinogenesis in Mice

Sharma

Paliwal²,

Janmeda³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Chemopreventive Efficacy of Moringa oleifera Pods Against 7, 12-Dimethylbenz[a]anthracene Induced Hepatic Carcinogenesis in Mice

Sharma

Paliwal²,

Janmeda³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…These stimulations indicated liver cell necrosis and the magnitude of increase correlated with the extent necrosis (Porchezhian and Ansari, 2005;Shyamal et al, 2006). The three treatments with ginger in paracetamolinduced animals were characterized by alleviation and normalization in the both transaminases activity.…”

Section: Discussionmentioning

confidence: 91%

“…The three treatments with ginger in paracetamolinduced animals were characterized by alleviation and normalization in the both transaminases activity. The paracetamol induction caused liver damage; the present hepatotoxicant was metabolized by sulfation and glucuronidation to reactive metabolites and then activated by cytochrome-P-450 system to produce liver injury (Shyamal et al, 2006). Ginger treatments presented hepatoprotective effect in liver function enzymes against paracetamol influences.…”

Section: Discussionmentioning

confidence: 99%

Effect of Zingiber Officinale on paracetamol-induced genotoxicity in male rats

Salah¹,

Abdouh²,

Booles³

et al. 2012

J. Med. Plants Res.

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The mutagenic effects of paracetamol (acetaminophen) in male rat using in vivo mutagenicity tests, chromosomal aberrations of somatic and germ cells, molecular assay and biochemical were studied. Paracetamol genotoxicity on normal divided cells has been reported. The data obtained showed that the ability of paracetamol to bind and interact with genetic material lead to changes in chromosomal behavior and structure during mitosis. The significant increase in chromosomal aberration, the changes in the number, position and intensity of bands, liver and renal damages induced by paracetamol may be attributed to the fact that paracetamol can induce genotoxicity through DNA damage. Paracetamol also stimulated AST and ALT activity, these stimulations indicated liver cell necrosis. Paracetamol-induced acute renal damage by the elevations in blood urea, uric acid and creatinine levels. Paracetamol showed abnormal values of protein profile in blood. The treatments with ginger presented hepatoprotective effect, also ginger can protect against oxidative kidneys tissue damage that reduced lipid peroxiation in liver and kidneys. The possible mechanism by which ginger exhibited significant protection against paracetamol-induced genotoxicity and hepatotoxicity may be due to its antioxidant effect. It may also be responsible for the hepatoprotective activity and attainment of normal frequencies of chromosomal aberration in ginger-treated rats. Thus, the present study indicated that the genotoxicity products at low concentration and for long time treatment showed the hazard of paracetamol addiction on human's life.

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“…The increased levels of serum enzymes (ALT, AST, LDH and ALP) may be interpreted as a result of liver cell destruction or changes in membrane permeability. These enzymes are characteristic of liver cell damage; therefore their release into serum after APAP administration confirmed liver damage [26]. Administration of APAP causes significant increase in lipid peroxidation, depletion of hepatic glutathione (GSH), hypoalbuminemia and hypoproteinemia [27,28].…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of a Standardized Fraction from Vitex negundo Linn. Against Acetaminophen and Galactosamine Induced Hepatotoxicity in Rodents

Sharma¹,

Suri²,

Ch³

et al. 2016

Biochem Anal Biochem

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The use of Vitex negundo Linn. (Family: verbenaceae) is well documented in ayurveda and traditional Indian system of medicine for variety of diseases and liver ailments. The aim of the study was to investigate liver protective efficacy of a standardized bioactive fraction (SF) from Vitex negundo Linn. against acetaminophen (APAP) and galactosamine (GalN) hepatotoxicity. SF was tested at doses 12.5, 25, 50 and 100mg/kg, p.o. using both prophylactic and curative treatment schedule against APAP and GalN hepatotoxicity in mice and rats respectively. Isolated markers agnuside and negundoside were tested against APAP toxicity. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and albumin were estimated in serum and triglycerides (TG), total protein, glutathione (GSH) and lipid peroxidation (LP) in liver homogenate. Histopathological studies were carried out against APAP induced hepatotoxicity. SF exhibited significant hepatoprotection against APAP and GalN evident by restoration of ALT, AST, LDH, ALP, bilirubin, TG, albumin and total protein. Levels of LP and GSH also exhibited significant dose dependent recovery when treated with SF. Agnuside and negundoside also exhibited dose dependent protection against APAP induced hepatotoxicity. Microscopic examination of histopathological sections of liver confirmed hepatoprotective potential of SF. Results of the study suggest significant value of SF as hepatoprotective with sufficient safety margin as no mortality and change in general gross behavior was observed up to 2000 mg/kg, p.o. Hepatoprotective mechanism of SF may be due to its antioxidant activity exhibited by protection against increased lipid peroxidation and maintained glutathione status. It is apparent from the present study that agnuside and negundoside are the active ingredients in SF and can be responsible for the activity of SF.

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Hepatoprotective effects of Pittosporum neelgherrense Wight&Arn., a popular Indian ethnomedicine

Cited by 28 publications

References 9 publications

Chemopreventive Efficacy of Moringa oleifera Pods Against 7, 12-Dimethylbenz[a]anthracene Induced Hepatic Carcinogenesis in Mice

Chemopreventive Efficacy of Moringa oleifera Pods Against 7, 12-Dimethylbenz[a]anthracene Induced Hepatic Carcinogenesis in Mice

Effect of Zingiber Officinale on paracetamol-induced genotoxicity in male rats

Protective Effect of a Standardized Fraction from Vitex negundo Linn. Against Acetaminophen and Galactosamine Induced Hepatotoxicity in Rodents

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