Hepatoprotective effects of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats

Ye, Xingshen; Feng, Yibin; Tong, Yao; Ng, Kwan‐Ming; Tsao, Sai‐Wah; Lau, George; Sze, Stephen Cho Wing; Zhang, Yanbo; Tang, Jun; Shen, Jiangang; Kobayashi, Seiichi

doi:10.1016/j.jep.2009.04.003

Cited by 91 publications

(74 citation statements)

References 29 publications

(34 reference statements)

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“…At present, there is considerable interest in natural plant products, particularly those used in traditional medicine. These products may be useful in the development of new drug and applications, including liver diseases induced by the toxic agents Ye et al 2009). This type of investigation has been shown to represent an effective strategy for selecting the medicinal plants for the development of new drugs, since around 80% of the world's population uses the products derived from the plants in their basic healthcare (Farnsworth 1994;Kaur et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Bark Extract of Bathysa cuspidata in the Treatment of Liver Injury Induced by Carbon Tetrachloride in Rats

Gonçalves

Matta

Novaes

et al. 2014

Braz. arch. biol. technol.

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Section: Introductionmentioning

confidence: 99%

Bark Extract of Bathysa cuspidata in the Treatment of Liver Injury Induced by Carbon Tetrachloride in Rats

Gonçalves

Matta

Novaes

et al. 2014

Braz. arch. biol. technol.

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“…As chronic and acute hepatic affections continue to cause severe health problems all over the world, numerous experimental studies have taken considerable interest in the role of natural products such as extract of Coriandrum sativum [15], root of Taraxacum officinale [16], aqueous extract of Coptidis rhizoma [17], extract of Pracparatum mungo (Phaseolus mungo L.) [18], sea buckthorn seed oil (Hippophae rhamnoides L., Elaeagnaceae) [19] and the alga Laminaria japonica [20] in treating hepatic disorders.…”

Section: Introductionmentioning

confidence: 99%

Effect of Apitherapy Formulations against Carbon Tetrachloride-Induced Toxicity in Wistar Rats after Three Weeks of Treatment

Andriţoiu

Ochiuz

Andriţoiu³

et al. 2014

Molecules

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Abstract:The human body is exposed nowadays to increasing attacks by toxic compounds in polluted air, industrially processed foods, alcohol and drug consumption that increase liver toxicity, leading to more and more severe cases of hepatic disorders. The present paper aims to evaluate the influence of the apitherapy diet in Wistar rats with carbon tetrachloride-induced hepatotoxicity, by analyzing the biochemical determinations (enzymatic, lipid and protein profiles, coagulation parameters, minerals, blood count parameters, bilirubin levels) and histopathological changes at the level of liver, spleen and pancreas. The experiment was carried out on six groups of male Wistar rats. Hepatic lesions were induced by intraperitoneal injection of carbon tetrachloride (dissolved in paraffin oil, 10% solution). Two mL per 100 g were administered, every 2 days, for 2 weeks. Hepatoprotection was achieved with two apitherapy diet formulations containing honey, pollen, propolis, Apilarnil, with/without royal jelly. Biochemical results reveal that the two apitherapy diet formulations have a positive effect on improving the enzymatic, lipid, and protein profiles, coagulation, mineral and blood count parameters and bilirubin levels. The histopathological results demonstrate the benefits of the two apitherapy diet formulations on reducing toxicity at the level of liver, spleen and pancreas in laboratory animals.

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“…Increase of free radical production has been implicated in the pathogenesis of acute hepatic disorders (Chandrashekhar et al, 2010). The metabolism of CCl 4 by cytochrome P450 leads to the formation of free radicals, inducing lipid peroxidation and impairing antioxidant status (Ye et al, 2009). Results showed that the levels the levels of ALT and AST were significantly decreased (P<0.001 and P<0.01, respectively) in administrating each dose group of TASEA and TASBU compared to liver injury control.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective activity of Trapa acornis shell extracts against CCl4-induced liver injury in rats

Kang

2012

Afr. J. Pharm. Pharmacol.

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Trapa acornis (TA) pulp is one of the most popular vegetables and fruits with unique taste in China. Our previous study showed that T. acornis shell (TAS) had strong antioxidant activity in vitro. Polyphenols and flavonoids have contributed to antioxidant activity; and hepatoprotective activity also has relationship with antioxidant activity. Nevertheless, there have been no reports on total phenolic content (TPC) and total flavonoid content (TFC) of extracts of TAS and hepatoprotective activity of TAS extracts against CCl 4 -induced liver injury in rats. There was intragastric administration of ethyl acetate extract (TASEA) and n-butanol extract (TASBU) of T. acornis shell in rats for 8 days; and the last administration was done after 2 h, except for the normal control group. Other groups were all given 0.4% CCl 4 at the dose of 100 mL/kg diluted in olive oil by intraperitoneal injection. Results showed that the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in each treatment group were significantly decreased (P<0.001 and P<0.01 respectively). The level of malondialdehyde (MDA) was significantly decreased in liver tissue (P<0.001). In addition to TASEA (200 mg/kg b.w.), the level of superoxide dismutase (SOD) in liver tissue for treatment group was significantly increased (P<0.001, P <0.01 and P<0.05, respectively). It is demonstrated that extracts of TAS had hepatoprotective effect on CCl 4 -induced liver injury, which may be attributable to its antioxidant activity.

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Hepatoprotective effects of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats

Abstract: The study is the first time to demonstrate that CRAE has hepatoprotective effect on acute liver injuries induced by CCl4, and the results suggest that the effect of CRAE against CCl4-induced liver damage is related to antioxidant property.

Cited by 91 publications

References 29 publications

Bark Extract of Bathysa cuspidata in the Treatment of Liver Injury Induced by Carbon Tetrachloride in Rats

Bark Extract of Bathysa cuspidata in the Treatment of Liver Injury Induced by Carbon Tetrachloride in Rats

Effect of Apitherapy Formulations against Carbon Tetrachloride-Induced Toxicity in Wistar Rats after Three Weeks of Treatment

Hepatoprotective activity of Trapa acornis shell extracts against CCl4-induced liver injury in rats

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