Hepatoprotective activity of Trapa acornis shell extracts against CCl4-induced liver injury in rats

Kang, Wen-yi

doi:10.5897/ajpp12.071

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…T. natans fruit peel (shell) extract is reported to reduce hepatotoxicity induced by CCl4 and paracetamol. [ 5 6 ] There is no information available about their hepatoprotective properties in favor of intoxicated liver injury induced by antitubercular drugs. Accordingly, our objective is to perform the study of the hepatoprotective properties of hydroalcoholic extract of T. natans fruit peel against antitubercular drug-intoxicated rats as an experimental model.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective evaluation of Trapa natans against drug-induced hepatotoxicity of antitubercular agents in rats

Hussain¹,

Subaiea²,

Firdous³

2018

Phcog Mag

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Background:Medicinal herbs are significantly effective against a variety of liver disorders and Trapa natans was traditionally used for the treatment of anti-inflammatory, pain disorder, and various types of hepatic ailment.Objective:The purpose of this study was to evaluate the hepatoprotective activity of T. natans fruit peel extract against antitubercular drugs (isoniazid + rifampicin [INH + RIF])-induced hepatotoxicity in rats.Materials and Methods:Liver toxicity was induced by INH + RIF at a dose level of 50 mg/kg each, intraperitoneally. for 15 days. Fifty percent ethanolic extract of T. natans (TNE) at a dose of 200 and 400 mg/kg was administered orally once daily for 15 days. The hepatoprotective activity was assessed using various biochemical parameters such as aspartate transaminase, alanine transaminase, alkaline phosphate, lactate dehydrogenase, albumin, cholesterol, and bilirubin. Furthermore, in vivo antioxidant activities and histopathological investigation were performed to assess hepatoprotective activity.Results:Obtained results demonstrated that the level of liver marker enzymes and antioxidant parameters were significantly altered by INH + RIF treatment. Treatment with T. natans peel extract causes significant (P < 0.01 to P < 0.001) reduction in liver injury & normalized all altered liver marker enzymes. In addition, TNE significantly normalized the activity of antioxidant enzymes, namely, lipid peroxidation (P < 0.01 to P < 0.001), reduced glutathione (P < 0.05 to P < 0.001), superoxide dismutase (P < 0.05 to P < 0.001), and catalase (P < 0.01 to P < 0.001) in the liver tissue of INH + RIF-treated groups. Histological observations of the liver tissues correlated with the biochemical observations.Conclusion:These findings powerfully support that the protective effect of T. natans fruit peel extract against liver injury which may be attributed to its hepatoprotective activity due to normalizes the altered liver marker enzymes and antioxidant defense status and thereby contributed to its antihepatotoxic potential.SUMMARY Hepatotoxicity was induced in rats by intraperitoneal injection of antitubercular drugs (Isoniazid + Rifampicin at dose level of 50 mg/kg each) for 15 daysThe liver was screened for various marker enzymes and antioxidant parameters, which showed significant increase in the level of marker enzymes confirming induced hepatotoxicityHepatotoxic rats on treatment with T. natans peel extract (200 and 400 mg/kg) resulted in significant (P < 0.01 to P< 0.001) reduction in liver marker enzymes and antioxidant parametersThus, it can be concluded that Trapa natans fruit peel extract showed hepatoprotective potential against antitubercular drugs induced hepatotoxicity. Abbreviations used: INH: Isoniazid; RIF: Rifampicin; DIH: Drug-induced hepatotoxicity; CMC: Carboxy methyl cellulose; ALT: Alanine transaminase; ALP: Alkaline phosphate; CHL: Total cholesterol; ALB: Albumin; LDH: Lactate dehydrogenase; LPO: Lipid peroxidation; CAT: Catalase; GSH: Reduced glutathione; SOD: Superoxide dismutas...

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Section: Introductionmentioning

confidence: 99%

Hepatoprotective evaluation of Trapa natans against drug-induced hepatotoxicity of antitubercular agents in rats

Hussain¹,

Subaiea²,

Firdous³

2018

Phcog Mag

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Study on the Evaluation of (Heavy) Metals in Water and Sediment of Skadar Lake (Montenegro), with BCF Assessment and Translocation Ability (TA) by Trapa natans and a Review of SDGs

Krivokapic

2021

Water

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Skadar Lake is a crypto-depression, a shallow lake, near to the Adriatic coast; the largest in the Balkan Peninsula and in southeastern Europe. The Lake is a very complex aquatic ecosystem in which anthropogenic activities have a long history in terms of the impact on wildlife and the overexploitation of natural resources. Such consequences related to heavy metals represent a global problem. Heavy metal pollution can cause severe ecological consequences in aquatic ecosystems. These pollutants accumulate in the aquatic biota from water, sediment and through the food chain, the impact can magnify. Aquatic macrophytes are good indicators of the health of a water body. This research was carried out to evaluate heavy metals concentration in water, sediment and in the aquatic macrophyte Trapa natans (water chestnut), with BCF (bio-concentration factor), BSAF (biota sediment accumulation factor) and TA (translocation ability), in order to determine the water quality of this specific part of the aquatic ecosystem of Skadar Lake near to the settlement of Vranjina, a fishing village. The determination of heavy metals was carried out by ICP-OES. (Inductively coupled plasma-optical emission spectrometry). Statistical analysis was established by R statistical computing software, version 3.5.3. The metal concentration in the water decreases in the following sequential order: As > Pb > Zn > Cu = Al = Cr > Cd = Hg. Meanwhile in the sediment, the descending sequence is as follows: Cr > Zn > Cu > Pb > As > Cd > Hg. The ability of plants to absorb and accumulate metals from the aqueous growth medium was assessed using a bio-concentration factor. The BCF in the stem, leaf and fruit has high values, mainly, of Al, Cr, Cu and Zn, while for the biota sediment accumulation factor, the highest values were recorded for the following elements: Hg, Cd, Cu and Zn. Analysis of the translocation ability of TA shows the dominance of four metals: Pb, Cd, Hg and As. A significant positive Kendall’s correlation coefficient between sediment and stem (R = 0.73, p < 0.05), stem and leaf (R = 0.87, p < 0.05) and leaf and fruit (R = 1, p < 0.05) was established.

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Hepatoprotective activity of Trapa acornis shell extracts against CCl4-induced liver injury in rats

Cited by 2 publications

References 26 publications

Hepatoprotective evaluation of Trapa natans against drug-induced hepatotoxicity of antitubercular agents in rats

Hepatoprotective evaluation of Trapa natans against drug-induced hepatotoxicity of antitubercular agents in rats

Study on the Evaluation of (Heavy) Metals in Water and Sediment of Skadar Lake (Montenegro), with BCF Assessment and Translocation Ability (TA) by Trapa natans and a Review of SDGs

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