Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats

Feng, Yibin; Siu, Ka-Yu; Ye, Xingshen; Wang, Ning; Yuen, Man‐Fung; Leung, Chung‐Hang; Tong, Yao; Kobayashi, Seiichi

doi:10.1186/1749-8546-5-33

Cited by 64 publications

(47 citation statements)

References 12 publications

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“…CCl 4 causes hepatocyte injury that is characterized by centrilobular necrosis that is followed by hepatic fibrosis [34]. Administration of carbon tetrachloride elevated the A major defiance mechanism involves in the antioxidant including super oxide dismutase, catalase glutathione peroxidase which convert active oxygen molecules into nontoxic compounds.…”

Section: Discussionmentioning

confidence: 99%

In-Vitro Antioxidant and in-Vivo Hepato Protective Activity of Ethanol Extracts From the Bark of Shorea Robusta (Dipterocarpaceae) Against Carbon Tetra Chloride Induced Liver Toxicity in Rats

Biswas¹

2016

Asian J Pharm Clin Res

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Objective: The study is designed for the evaluation of in vivo hepatoprotective and in vitro antioxidant activity of ethanol extracts from the bark of Shorea robusta (EESR) (Dipterocarpaceae) by carbon tetra chloride (CCl 4 ) induced hepatotoxicity in rats.Methods: EESR was evaluated for hepatoprotective activity in rats by inducing liver damage by CCl 4 . The antioxidant activity of EESR was assayed by various in vitro antioxidant methods and activities were compared to standard ascorbic acid. Results:Ethanol extracts at an oral dose 200 mg/kg and 400 mg/kg exhibited a significant (*p<0.005) protective effects by lowering the level of serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, alkaline phosphatase, serum bilirubin, total cholesterol, and increasing the level of total proteins as compared to silymarin (50 mg/kg) used as positive control. The extracts exhibit significant antioxidant activity in various in vitro antioxidant models. Conclusion:From these studies, we are concluding that, the EESR have potent hepatoprotective effects and have antioxidant properties, hence can be used as a natural product against liver damage.

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Section: Discussionmentioning

confidence: 99%

In-Vitro Antioxidant and in-Vivo Hepato Protective Activity of Ethanol Extracts From the Bark of Shorea Robusta (Dipterocarpaceae) Against Carbon Tetra Chloride Induced Liver Toxicity in Rats

Biswas¹

2016

Asian J Pharm Clin Res

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“…The in vivo study revealed that the protective role of chitosan nanoparticle alone or in combination with quercetin against oxidative stress and hepatotoxicity induced by carbon tetrachloride in rat model was evaluated. The selected doses of CCl 4 , chitosan nanoparticles and quercetin were literature based [68]- [70], respectively). In the current study, treatment with CCl 4 induced severe hepatotoxicity and oxidative stress as well as histological changes typical to those reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

El-Denshary¹,

Aljawish²,

El‐Nekeety³

et al. 2015

SNL

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This study was conducted to prepare chitosan nanoparticles (CNPs), to determine their properties and to evaluate the synergistic protective role of CNPs alone or in combination with quercetin (Q) against oxidative stress and hepatotoxicity in rats. Female Sprague-Dawley rats were divided into 12 groups (7 rats/group) and were maintained on their respective diet for 3 weeks as follow: control group, the group treated with CCl4 (100 mg/kg b.w twice a week); the groups received CNPs at low and high doses (140 and 280 mg/kg b.w); the group received Q (50 mg/kg b.w); the groups received CNPs at the low or high doses plus Q and the groups treated with CCl4 plus Q and/or CNPs at the two tested doses. Blood and liver samples were collected at the end of experiment period for biochemical and histological studies. The results indicated that chitosan showed deacetylation degree of 17.5% and 19.2% and the molar mass average of monomer was 168.35 g/mol and 169.1 g/mol by UV and IR methods respectively. The particle size of CNPs was around 100 nm with a rough surface. The in vivo results revealed that CCl4 induced biochemical and histological changes typical to those reported in the literature. Animals treated with CNPs at the two tested doses alone or in combination with Q were comparable to the control. CNPs alone or plus Q succeeded to induce significant improvements in the biochemical parameters and histological picture of the liver in rats treated with CCl4. This improvement was in dose-dependent manner for CNPs and was * Corresponding author. E. S. El-Denshary et al. 37more pronounced in the group treated with the high dose plus Q. It could be concluded that both CNPs and Q could induce protection against hepatotoxicity. Consequently, CNPs was a promise candidate as drug delivery in liver diseases treatments.

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“…Animals were divided into eight groups (10 rats/group) and were maintained on their respective diet and treated orally for 3 weeks as follows: group1; normal control animals which fed on basal diet and water without any treatment, group 2; animals treated with CCl 4 suspended in corn oil (0.1 ml/kg b.w) twice a week (Feng et al, 2010), group 3; rats treated with aqueous solution of AgNPs (50 mg/kg b.w), group 4; rats were treated with AgNPs plus CCl 4 , group 5; rats treated with water extract of S. nigrum leaves (0.5 mg/kg b.w), group 6, rats treated with AgNPs plus S. nigrum leaves extract, group 7; rats were treated with S. nigrum leaves extract plus CCl 4 , group 8; rats were treated with AgNPs and CCl 4 plus S. nigrum leaves extract.…”

Section: Experimental Designmentioning

confidence: 99%

Modulation of hepatotoxicity, DNA fragmentation and gene expression of Solanum nigrum leaves extract in rats treated with silver nanoparticles

2017

J App Pharma Sci

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The current study aimed to determine the antioxidant compounds in Solanum nigrum (S. nigrum) leaves extract, to synthesize silver nanoparticles (AgNPs) and to evaluate the protective role of the extract against the hepatotoxicity and genotoxicity of AgNPs compared to CCl4 in rats. Eight groups of female Sprague-Dawley rats were treated orally for 3 weeks included the control group, CCl4-trared group (0.1 ml/kg b.w twice a week), AgNPs-treated group (50 mg/kg b.w/day), AgNPs plus CCl4-treated group, S. nigrum leaves extract-treated group (0.5 mg/kg b.w) and the groups treated with AgNPs and/or CCl4 plus the extract. The results indicated that the extract was rich in the total phenolic, flavoniods and β-carotene. The size of synthesized AgNPs was 30-50 nm. Administration of AgNPs and/or CCl4 resulted in severe hepatotoxicity and histological changes, increased DNA fragmentation and down regulation of antioxidant gene expression in liver. The extract was safe and succeeded to mitigate the hazards effect of AgNPs and/or CCl4. It could be concluded that AgNPs have toxic effects and caution should be taken when they use in food or medical application. S. nigrum extract succeeded to protect the liver due to its higher content of antioxidant compounds.

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Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats

Cited by 64 publications

References 12 publications

In-Vitro Antioxidant and in-Vivo Hepato Protective Activity of Ethanol Extracts From the Bark of Shorea Robusta (Dipterocarpaceae) Against Carbon Tetra Chloride Induced Liver Toxicity in Rats

In-Vitro Antioxidant and in-Vivo Hepato Protective Activity of Ethanol Extracts From the Bark of Shorea Robusta (Dipterocarpaceae) Against Carbon Tetra Chloride Induced Liver Toxicity in Rats

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

Modulation of hepatotoxicity, DNA fragmentation and gene expression of Solanum nigrum leaves extract in rats treated with silver nanoparticles

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