Hepatoprotective effect of withanolide-rich fraction in acetaminophen-intoxicated rat: decisive role of TNF-α, IL-1β, COX-II and iNOS

Abstract

WRF may exert its hepatoprotective action by alleviating inflammatory and oxido-nitrosative stress via inhibition of TNF-α, IL-1β, COX-II and iNOS.

Neuroprotective effect of Azadirachta indica standardized extract in partial sciatic nerve injury in rats: evidence from anti-inflammatory, antioxidant and anti-apoptotic studies

“…Cell apoptosis in integral part of various neurodegenerative conditions and inducible nitric oxide synthase (iNOS) has been reported to play a vital role in either apoptosis or necrosis (Devkar et al, 2016[21]; Kandhare et al, 2015[44]; Pannu and Singh, 2006[65]). Furthermore, the balance between Bcl-2-associated X protein (Bax) and B-cell lymphoma 2 (Bcl-2) has an important factor in cell survival (Kandhare et al, 2015[42]; Oltvai et al, 1993[64]).…”

Protective effect ofL-glutamine against diabetes-induced nephropathy in experimental animal: Role of KIM-1, NGAL, TGF-β1, and collagen-1

“…Hence, alteration in the levels of BUN, creatinine, and uric acid in serum, as well as urine, reflected renal dysfunction. 2,51 Glucosuria induces an osmotic diuresis and dehydration that resulted in a condition of prerenal acute renal failure (ARF). The similar results were noted in a present investigation where 4-week post STZ administration resulted in significantly increased serum albumin, BUN, creatinine, and uric acid as well as urinary albumin excretion.…”

Silkworm pupa oil attenuates acetaminophen‐induced acute liver injury by inhibiting oxidative stress‐mediated NF‐κB signaling

“…TNF-α plays a decisive role in the progression of hepatic injury induced by APAP (Devkar et al, 2016). TNF-α plays a decisive role in the progression of hepatic injury induced by APAP (Devkar et al, 2016).…”

“…The increased level of TNF-α makes TNF-α to bind to its receptor TNF-α receptor 1 (TNF-R1), which drives the activation of hepatic apoptosis and necrosis signaling (Chao, Wang, & Ding, 2017;Filliol et al, 2016). Inhibition of proinflammatory cytokines production attenuates inflammation-mediated hepatocyte injury following APAP toxicity (Devkar et al, 2016;Hussan et al, 2015). The levels of IL-6 and IL-12 F I G U R E 2 Effects of silkworm pupa oil on hepatic histology (original magnification 100×).…”