Hepatoprotective effect of Ginkgo biloba leaf extract on lantadenes-induced hepatotoxicity in guinea pigs

Parimoo, Haroon Ashraf; Sharma, Rinku; Patil, Rajendra D.; Sharma, Om P.; Kumar, Pawan; Kumar, Neeraj

doi:10.1016/j.toxicon.2014.01.013

Cited by 36 publications

(22 citation statements)

References 39 publications

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“…Concentration of purified lantadenes obtained was 3.10 mg/g of dry matter of lantana leaf powder. Reversed-phase HPLC analysis of lantadenes confirmed the presence of LA as the major (72.82 %) component of purified lantadenes (Parimoo et al 2014). …”

Section: Discussionmentioning

confidence: 79%

“…A total of 310 mg lantadenes was obtained from 100 g dried leaf powder. The reversed-phase HPLC analysis revealed the presence of 72.82 % LA in the sample (Parimoo et al 2014).…”

Section: Experimental Animals and Their Managementmentioning

confidence: 99%

“…We observed that approximately 625 g of green leaves yielded 100 g of dried leaf powder. Extraction of lantadenes from powdered leaves was carried out as described by Parimoo et al (2014). A total of 310 mg lantadenes was obtained from 100 g dried leaf powder.…”

Section: Experimental Animals and Their Managementmentioning

confidence: 99%

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Sub-acute toxicity of lantadenes isolated from Lantana camara leaves in guinea pig animal model

et al. 2015

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The sub-acute toxicity of lantadenes isolated from Lantana camara leaves was studied in guinea pig laboratory animal model. A total of 20 guinea pigs of either sex were divided into five groups. Group I served as control, while groups II, III, IV, and V were orally administered lantadenes at the dose rate of 100, 50, 25, and 12.5 mg/kg body weight (bw), respectively for 28 days. The levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, acid phosphatase, total bilirubin, blood urea nitrogen, and creatinine were estimated in serum. The effect of lantadenes on lipid peroxidation, superoxide dismutase, reduced glutathione, and catalase was monitored in liver homogenate. The lantadenes at the dose rate of 25 mg/kg bw in animals of group IV did not result in mortality, produced gross and histopathological changes characteristic of sub-acute toxicity in liver and kidneys, and resulted in the highest levels of serum liver marker enzymes. Elevated lipid peroxidation levels and decreased levels of superoxide dismutase and catalase in group IV indicated free-radical-induced damage by lantadenes. It was concluded that lantadenes produced a dose-dependent toxicity and the dose level of 25 mg/kg bw was the sub-acute toxic dose which induced significant fibrosis and necrosis in liver of guinea pigs. To the best of our knowledge, this is the first report on the study of sub-acute toxicity of lantadenes in guinea pig animal model which mimic the actual livestock lantana toxicity cases in field conditions.

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Section: Discussionmentioning

confidence: 79%

“…A total of 310 mg lantadenes was obtained from 100 g dried leaf powder. The reversed-phase HPLC analysis revealed the presence of 72.82 % LA in the sample (Parimoo et al 2014).…”

Section: Experimental Animals and Their Managementmentioning

confidence: 99%

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Sub-acute toxicity of lantadenes isolated from Lantana camara leaves in guinea pig animal model

et al. 2015

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“…In consequence, further studies are encouraged to confirm it. In this sense, these plants contain chemical stressors, such as benzopyrene, alkaloids and lantadenes (35) , as well as antioxidants (e.g. vitamins) (36) .…”

Section: Discussionmentioning

confidence: 99%

Bioavailability of phenolic compounds and redox state of murine liver and kidney as sex-dependent responses to phytoextracts

Albrecht¹,

Guzmán²,

Cittadini³

et al. 2017

Rev Fac Cien Med Univ Nac Cordoba

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Background: Plant extracts can be obtained to carry bioactive compounds, useful for prevention and treatment of different illnesses. This also supports the intake of teas as functional beverages. Nonetheless, it is incompletely known whether these extracts can act as effective sources and vehicles de phenolic compounds (phenolics/polyphenols) to reach their targets. Objective: To establish whether phytoextract ingestion modified in a sex-dependent manner the phenolic bioavailability and redox response in liver and kidney. Method: BALB/C mice ingested for a month 100 mg/Kg/d of extracts (tea-like) from Aspidosperma quebracho-blanco (AQB), Lantana grisebachii (LG) or Ilex paraguariensis (IP). Then, phenolics, peroxides and nitrites were analyzed by spectrophotometry. Also, phenolic permeation from digested and undigested extracts was evaluated in vitro with a rat jejunum-based assay. Results: Phenolic permeation depended on extract digestion. In males, IP showed a special time course of hepatic phenolics, whereas all extracts decreased renal phenolics at 15 days. Extracts induced hepatic lipoperoxides at 15 days. LG reduced renal hydroperoxides at 15 days and hepatic nitrites at 30 days, whereas AQB and IP reduced renal lipoperoxides and nitrites at 30 days. In females, extracts reduced hydroperoxides, with LG and AQB also reducing lipoperoxides. IP increased renal lipoperoxides at 30 days. Conclusion: IP was a relevant phenolic source. Sex-dependent responses were found in all variables, which should be considered to prevent misleading generalizations in phytodrug bioprospecting.

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“…One of those plants that has been highly studied is Ginkgo biloba L. due to its use in traditional medicine, but also by professionals in the medical field in order to treat problems typically associated with aging, such as intermittent claudication, decreased mental vitality in old age (mental confusion, memory loss, dementia praecox, concentration problems), poor circulation and tinnitus (Diamond et al, 2000). The extracts from G. biloba, such as EGb761 in Tebonin ® , are also used as alternative therapy against Alzheimer's disease (van Beek and Montoro, 2009;Parimoo et al, 2014). The products with this plant are commercially available in various forms: leaves for infusions preparation, standardized extracts, pills, capsules or oral solutions (Liu et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Gamma irradiation improves the extractability of phenolic compounds in Ginkgo biloba L.

Pereira

Barros

Dueñas

et al. 2015

Industrial Crops and Products

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Irradiation has been increasingly recognized as an effective decontamination technique that ensures the chemical and organoleptic quality of medicinal and aromatic plants.The aim of the present study was to evaluate the effects of gamma irradiation in the phenolic compounds of Ginkgo biloba L. (infusion and methanol/water extract), widely used in traditional medicine and in dietary supplements. Twenty-five compounds were detected, eighteen of which were flavonoids, one phenolic acid, five terpene lactones and one unknown compound. Among the quantified phenolic compounds, flavonoids were the main group present, being two kaempferol derivatives the major compounds found: kaempferol-3-O-dirhamnosylglucoside and kaempferol-3-O-rutinoside. The irradiation with the highest dose (10 kGy) is sufficient to guarantee the product disinfestation and microbial decontamination, also contributing to an increase in the extractability of phenolic compounds, both in methanol/water and infusion preparations.

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Hepatoprotective effect of Ginkgo biloba leaf extract on lantadenes-induced hepatotoxicity in guinea pigs

Cited by 36 publications

References 39 publications

Sub-acute toxicity of lantadenes isolated from Lantana camara leaves in guinea pig animal model

Sub-acute toxicity of lantadenes isolated from Lantana camara leaves in guinea pig animal model

Bioavailability of phenolic compounds and redox state of murine liver and kidney as sex-dependent responses to phytoextracts

Gamma irradiation improves the extractability of phenolic compounds in Ginkgo biloba L.

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