Hepatoprotective Effect of Gamma-mangostin for Amelioration of Impaired Liver Structure and Function in Streptozotocin-induced Diabetic Mice

Husen, Saikhu Akhmad; Winarni, Dwi; Salamun,; Ansori, Arif Nur Muhammad; Susilo, Raden Joko Kuncoroningrat; Hayaza, Suhailah

doi:10.1088/1755-1315/217/1/012031

Cited by 30 publications

(30 citation statements)

References 20 publications

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“…Indonesia has a high biodiversity with may natural medicine sources. It has around 30,000 different plant species, of which 7,000 are known to possess medicinal properties 7,8,9,10 . Sambiloto is a medicinal herb that is cultivated in Southeast Asia.…”

Section: Resultsmentioning

confidence: 99%

Sambiloto (Andrographis paniculata) Extract Improves the Performance of Animal Model Infected with Escherichia coli

Hidanah¹,

Sabdoningrum²,

Arif³

et al. 2020

IJFMT

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This study aims to understand the effect of natural antibiotics from sambiloto (Andrographis paniculata) extract to laying hens infected with Avian Pathogenic Escherichia coli (APEC). The activation test of sambiloto was performed by using a dilution method included a minimum inhibitory concentration (MIC) and a minimum bactericidal concentration (MBC). Laying hens were distributed into five groups: normal group, APEC group with no treatment, and APEC group given 10%, 20%, 30% sambiloto extract for two weeks. The data were analyzed using ANOVA and continued with the F test. Based on the results, the 30% extract has improved the hen day production (HDP) of laying hens infected with APEC.

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Section: Resultsmentioning

confidence: 99%

Sambiloto (Andrographis paniculata) Extract Improves the Performance of Animal Model Infected with Escherichia coli

Hidanah¹,

Sabdoningrum²,

Arif³

et al. 2020

IJFMT

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“…A hepatoprotective effect, which has previously been shown as one of the actions of α-mangostin [ 159 ], and renoprotective action were also found in streptozotocin-induced diabetic mice [ 160 ]. Some authors have cited the compound α-mangostin ( 49 ) as having anticancer activities, being capable of inducing cell death via apoptosis of human colorectal carcinomas [ 161 , 162 ].…”

Section: Garcinia Species and Bioactive Compounmentioning

confidence: 99%

Medicinal Potential of Garcinia Species and Their Compounds

et al. 2020

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Garcinia is a genus of Clusiaceae, distributed throughout tropical Asia, Africa, New Caledonia, Polynesia, and Brazil. Garcinia plants contain a broad range of biologically active metabolites which, in the last few decades, have received considerable attention due to the chemical compositions of their extracts, with compounds which have been shown to have beneficial effects in several diseases. Our work had the objective of reviewing the benefits of five Garcinia species (G. brasiliensis, G. gardneriana, G. pedunculata, G. cambogia, and G. mangstana). These species provide a rich natural source of bioactive compounds with relevant therapeutic properties and anti-inflammatory effects, such as for the treatment of skin disorders, wounds, pain, and infections, having demonstrated antinociceptive, antioxidant, antitumoral, antifungal, anticancer, antihistaminic, antiulcerogenic, antimicrobial, antiviral, vasodilator, hypolipidemic, hepatoprotective, nephroprotective, and cardioprotective properties. This demonstrates the relevance of the genus as a rich source of compounds with valuable therapeutic properties, with potential use in the prevention and treatment of nontransmissible chronic diseases.

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“…On the 7 th and 14 th day after the last STZ injection, a fasting glucose level were measured using a glucometer. Mice which were labeled as diabetic mice were mice with the fasting blood glucose levels greater than 126 mg/dL (8,13,14).…”

Section: Experimental Designmentioning

confidence: 99%

Renoprotection by Garcinia mangostana L. pericarp extract in streptozotocin-induced diabetic mice

Ansori¹,

Kuncoroningrat²,

Hayaza³

et al. 2019

IJVS

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The purpose of this study was to evaluate the renoprotective effect of the Garcinia mangostana L. pericarp extract (GMPE) on plasma creatinine and renal proximal tubules of streptozotocin-induced diabetic mice. This study used 36 male Balb/c strain mice. The samples were divided into 6 groups, namely KN (normal control), KD (diabetic control), KM (metformin control), and P (treatment group) comprising: P1 (50 mg GMPE/kg body weight), P2 (100 mg GMPE/kg body weight), as well as P3 (200 mg GMPE/kg body weight). The GMPE and metformin suspension were administered orally for 14 days on the diabetic mice. The diabetes was induced by intraperitoneal injection of STZ multiple at low-dose of 30 mg/kg body weight daily for five consecutive days. On day 15, mice were terminated. Data of plasma creatinine and renal proximal tubule damage levels or the number of swelling and necrosis cells were analyzed. Interestingly and it showed that administration of GMPE could reduce the plasma creatinine level and ameliorate renal proximal tubules of streptozotocin-induced diabetic mice. In conclusion, the renoprotective effect of GMPE in streptozotocin-induced diabetic mice was associated with the attenuation in oxidative stress and inflammatory, which also had antidiabetic and antioxidant activities.

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Hepatoprotective Effect of Gamma-mangostin for Amelioration of Impaired Liver Structure and Function in Streptozotocin-induced Diabetic Mice

Cited by 30 publications

References 20 publications

Sambiloto (Andrographis paniculata) Extract Improves the Performance of Animal Model Infected with Escherichia coli

Sambiloto (Andrographis paniculata) Extract Improves the Performance of Animal Model Infected with Escherichia coli

Medicinal Potential of Garcinia Species and Their Compounds

Renoprotection by Garcinia mangostana L. pericarp extract in streptozotocin-induced diabetic mice

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