Hepatoprotective effect of ethanolic extract of Curcuma longa on thioacetamide induced liver cirrhosis in rats

Salama, Suzy Munir; Abdulla, Mahmood Ameen; AlRashdi, Ahmed S.; Ismail, Salmah; Alkiyumi, Salim Said; Golbabapour, Shahram

doi:10.1186/1472-6882-13-56

Cited by 124 publications

(104 citation statements)

References 49 publications

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“…They reported that at least 235 compounds, primary phenolic compounds and terpenoids have been identified from the species, including 22 diarylheptanoids and diarylpentanoids, 6 monomeric phenylpropene and 2 other phenolic compounds, 68 monoterpenes, 105 sesquiterpenes, 4 diterpenes, 3 triterpenoids, 4 steroids, 5 fatty acids, and 16 other compounds. Adaramoye et al, 2010;Baxla et al, 2013;Kim et al, 2012;Kim et al, 2014;Salama et al, 2013;Sengupta et al, 2011;Varalakshmi and Abhinov, 2015 (Unnikrishnan and Nishteswar, 2015). Even turmeric is traditionally applied on fresh cuts to stop bleeding by the rural and tribal population of India (Shivalingu et al, 2015), but there is no report explaining the possible involvement of turmeric in stopping the bleeding.…”

Section: Phytochemical Substancesmentioning

confidence: 99%

Antithrombotic activity of turmeric (<italic>Curcuma longa</italic>): A review

Sirisidthi

Kosai

Jiraungkoorskul

et al. 2016

IJARe

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The venous and arterial thromboembolic disorders are still be the major cause of morbidity and mortality worldwide. Now a days, the concept of "healthy diets" is very popular in the present lifestyle. So, the use of antithrombotic agents is of considerable interest in the role of natural food products and their bioactive components in the prevention and treatment of these disorders. Moreover, epidemiologic studies have provided evidence that foods with the thrombolytic/fibrinolytic effect could reduce the risk of thrombosis. "Blood thinner foods" have the antiplatelet, anticoagulant, and/or fibrinolytic properties. Natural foods that contain salicylates can mimic some of the antiplatelet effects of cardiovascular drug like aspirin. Fruits (i.e., grapefruit, guava, kiwi, pineapple, and watermelon), vegetables (i.e., alfalfa, beans, corn, potato, radish, and zucchini), and spices (i.e., chili, curry, ginger, rosemary and turmeric) are reported that they are containing salicylates compounds. Turmeric (Curcuma longa) is a small rhizomatous perennial herb belonging to Zingiberaceae family originating from Southeastern Asia. It is a folk remedy for applying on fresh cuts to stop bleeding and for the healing of wound. Further, turmeric has been shown to possess anticancer, antidiabetic, antifertility, anti-inflammatory, antimicrobial and antioxidant properties. Its phytochemical substances are alkaloids, curcuminoids, flavonoids, glycosides, saponins, which all of these contribute to its remedial properties. This article provides a brief overview of the antithrombotic activity of turmeric, C. longa to further provide an up-to-date review showing its importance.

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Section: Phytochemical Substancesmentioning

confidence: 99%

Antithrombotic activity of turmeric (<italic>Curcuma longa</italic>): A review

Sirisidthi

Kosai

Jiraungkoorskul

et al. 2016

IJARe

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“…Recent studies indicate that, turmeric and ginger have a hepatoprotective characteristic (Bardi et al, 2013;Salama et al, 2013). The hepatoprotective activities are mainly as result of their antioxidant properties.…”

Section: Discussionmentioning

confidence: 99%

Attenuation of Acetone Induced Liver and Kidney Injury by Ginger and Turmeric Root Powder in Chickens

El‐Rahman

Elwan

El-Shafei

et al. 2018

AJAS

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Ginger and turmeric are commonly used in food as spices with wellreported antioxidant activity. However, hepatoprotective and nephroprotective effects of ginger and turmeric have not been adequately studied. Therefore, the current study used chicken model with acetone induced liver and kidney injuries to evaluate the hepatoprotective and nephroprotective activities of ginger and turmeric because metabolic functions of chicken and human liver is similar. Eighty cocks were randomized into 5 experimental groups of chicks. The first one served as control. While the second group was received 350mg acetone/kg body weight (given in drinking water) per day for 30 days. The third, fourth and fifth groups were received ginger, turmeric and mix of ginger and turmeric by 1% in food respectively after treatment with acetone. Hematological parameters, liver and renal function tests, hepatic oxidative stress enzymes, as well as, histopathological examination scores were determined. Results indicated that, administration of acetone induces alteration in various hematological parameters, hepatic enzymes and hepatic oxidative stress enzymes in chickens. Dietary supplementation of ginger (GEN) and turmeric (TUR) caused a significant amelioration in some hematological parameters in acetone treated chickens. GEN and TUR treatments could reduce damage induced by acetone in alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), gamma-glutamyl transpeptidase (GGT), glucose, total protein and their fractions levels. Furthermore, acetone promoted a significant increase in urea, uric acid and creatinine levels, while treatment with GEN or TUR or GEN+TUR at the same time of treatment with acetone maintained urea and uric acid concentrations at a level similar to the control group. Interestingly, GEN, TUR and GEN+ TUR treatments significantly ameliorated effects of acetone on chickens by improving the levels of the main antioxidant enzymes (superoxide dismutase SOD, glutathione-S-transferase GST) and malondialdehyde (MDA) a reliable marker of lipid peroxidation in the cells. Histologically, acetone appeared to be hepatotoxic in chick's. Hepatocytes were sensitive to the treatment with acetone and contained large number of congested blood vesicles, cytoplasmic vacuoles, pyknotic nuclei, and lymphocytic infiltration in treated animals. Turmeric and ginger treatments improved the vast majority of hepatic changes. Our findings broadly confirmed that, the supplementation of ginger and turmeric significantly alleviated liver and kidney functions, hema-

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“…Combined treatment of curcumin and gingermaximize the protection of liver from injury and fibrogenesis due to CCl4 intoxication.curcumin and ginger returned collagen fiber distribution to almost normal pattern. [12][13][14][15][16][17] …”

Section: ] [6]mentioning

confidence: 99%

Hepatoprotective Activity of Spices

2017

IJSR

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Abstract:In history, spices have often been more valuable than gold or precious stones, and the trade of spices has been an extraordinarily influential factor. Many researchers have attempted to explain why spices are pleasant to taste. This work intends to aid researchers in the study of natural products useful in the treatment of liver diseases.The present work constitutes a review of the spices of natural origin with hepatoprotective activity.

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Hepatoprotective effect of ethanolic extract of Curcuma longa on thioacetamide induced liver cirrhosis in rats

Cited by 124 publications

References 49 publications

Antithrombotic activity of turmeric (<italic>Curcuma longa</italic>): A review

Antithrombotic activity of turmeric (<italic>Curcuma longa</italic>): A review

Attenuation of Acetone Induced Liver and Kidney Injury by Ginger and Turmeric Root Powder in Chickens

Hepatoprotective Activity of Spices

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