Hepatoprotective Constituents in Plants 14. Effects of Soyasapogenol B, Sophoradiol, and Their Glucuronides on the Cytotoxicity of tert-Butyl Hydroperoxide to HepG2 Cells1)

Glycyrrhizin Attenuates MPTP Neurotoxicity in Mouse and MPP+-Induced Cell Death in PC12 Cells

“…GL and GA reduce oxidative tissue damage due to tert-butyl hydroperoxide or ischemia-reperfusion injury (Nagai et al, 1991;Kinjo et al, 2003). Nevertheless, the effect of licorice compounds against the MPTP/MPP + toxicity remains uncertain.…”

“…Increasing evidence indicates that glycyrrhizin (GL), a triterpenoid saponin found in Glycyrrhiza glabrata, and its hydrolyzed metabolite 18β-glycyrrhetinic acid (GA) have anti-inflammatory, anti-cancer and anti-hepatotoxic effects (Jeong et al, 2002;Matsui et al, 2004;Agarwal et al, 2005). GL and GA have an anti-oxidant ability and reduce oxidative damage due to carbon tetrachloride, tert-butyl hydroperoxide or ischemia-reperfusion injury (Nagai et al, 1991;Jeong et al, 2002;Kinjo et al, 2003). GA attenuates tumor necrosis factor-α-, lipopolysaccharide-induced cell death in human hepatoblastoma cell line and cultured liver cells (Yoshikawa et al, 1999;Zheng & Lou, 2003).…”

Effects of Hepatoprotective Compounds from the Leaves of <i>Lumnitzera racemosa</i> on Acetaminophen-Induced Liver Damage <i>in Vitro</i>

“…The concentration of vehicle (DMSO) in each well is adjusted to contain 1%. [39][40][41] DPPH Radical Scavenging Assay The absorbance with various concentrations of the tested compounds dissolved in MeOH (100 µL) in a 96-well microtiter plate was measured at 515 nm as A blank . Then, 200 µM DPPH solution (100 µL) was added to each well, followed by incubation at room temperature for 30 min.…”

Soy and Soy-Based Foods: Role in Health and Nutrition

“…For instance, saponins appear to inhibit the infectivity of the AIDS virus (Nakashima et al 1989;Vlietinck et al 1998) and the herpes simplex virus type 1 (Hayashi et al 1997). Soyasaponins are reported to be hepatoprotective (Kinjo et al 2003) and have also shown a preventive effect on the growth of human colon cancer cells (Tsai et al 2010). The chemical structure significantly influences the saponins bioactivity; thus, individual soyasaponin I exhibits lipid peroxidation inhibitory effects in vitro, antiinflammatory properties in mice with TNBS-induced colitis (Lee et al 2010), and potentially reduces metastatic ability of cancer cells (Chang et al 2006).…”