Effects of Hepatoprotective Compounds from the Leaves of <i>Lumnitzera racemosa</i> on Acetaminophen-Induced Liver Damage <i>in Vitro</i>

Abstract

Phytochemical investigation of the n-BuOH fraction of the mangrove plant Lumnitzera racemosa WILLD. (Combretaceae) led to the isolation of one new flavonoid glycoside; myrcetin 3-O-methyl glucuronate (1), one new phenolic glycoside; lumniracemoside (2) and one new aliphatic alcohol glycoside; n-hexanol 1-Orutinoside (3), in addition to seven known compounds (4-10). The structures of these compounds were determined by spectroscopic analyses (UV, IR, high resolution-electrospray ionization (HR-ESI)-MS, one-and two-dimensional (1D-and 2D)-NMR). Compound 7 showed the highest hepatoprotective activity against acetaminophen-induced hepatotoxicity using human HepG2 cells at protection % value of 34.2 3.1%, while compounds 1, 2, 3, 6, and 9 showed weak to moderate hepatoprotective activity (11.6-18.9%). Almost all of these compounds showed stronger 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity compared with the standard Trolox. These results suggest the usefulness of this plant extract and the isolated compounds as promising hepatoprotective agents.

The Anticancer and Antioxidant Effects of Muscadine Grape Extracts on Racially Different Triple-negative Breast Cancer Cells

“…On the other hand, the genotypes A22-4-1/O41-3-1/A19-13-8 and D7-16-1/O41-3-1 showed the highest potency in inhibiting cell growth in MM-231 and MM-468, respectively. Taking in account that the beneficial properties of muscadine grapes are related to a variety of bioactive components that enhance antioxidant capacity and consequently anticancer activity (37,59,60), the genotypes A19-13-8 and D7-16-1 may be strong candidates for future breast cancer studies, having high antioxidant and anticancer activity, as well as a high phenolic content.…”

“…Measurement of the antioxidative activity. The antioxidative activity was measured by DPPH radical scavenging activity (37). Ten mg of the dried grape extracts dissolved in DMSO (1 ml) was used as a stock solution.…”

Natural Products for Prevention and Treatment of Chemical‐Induced Liver Injuries

“…In another study in the human HepG2 cell line, Lumnitzera racemosa Willd. Extract exerted the capability of scavenging radicals induced by APAP (Darwish et al., ). Furthermore, total saponins of Rosa laevigata Michx fruit showed the property of dose‐dependently preventing injury by inducing autophagy and inhibiting inflammation and apoptosis (Dong et al., ).…”

Corilagin Represses Epithelial to Mesenchymal Transition Process Through Modulating Wnt/β-Catenin Signaling Cascade

“…A number of agents derived from Mother Nature have been reported to be efficacious against tumor growth and progression [ 18 , 19 , 20 , 21 , 22 ]. Corilagin (CLG) is one such unique component of the tannin family [ 23 ], which can be found in a wide range of medical plants such as Longan, Lumnitzera racemose , Terminalia catappa L, and Phyllanthus species [ 24 , 25 , 26 ]. CLG has been reported to possess many pharmacological and biological properties including anti-inflammatory, hepatoprotective, anti-microbial, antihypertensive, antidiabetic, and anti-tumor activities [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ].…”