Natural Products for Prevention and Treatment of Chemical‐Induced Liver Injuries

Meng, Xiao; Li, Ya; Li, Sha; Gan, Ren‐You; Li, Hua-Bin

doi:10.1111/1541-4337.12335

Cited by 71 publications

(45 citation statements)

References 237 publications

(193 reference statements)

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“…Many dietary natural products possess the abilities to protect against liver diseases [ 18 , 19 , 20 ]. They have shown the potential in improving the integrity of the gut mucosa, modulating the composition of the microbiota, reducing the toxic metabolites and translocated bacteria in the liver [ 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

Meng

et al. 2018

Nutrients

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A variety of dietary natural products have shown hepatoprotective effects. Increasing evidence has also demonstrated that gut microorganisms play an important role in the hepatoprotection contributed by natural products. Gut dysbiosis could increase permeability of the gut barrier, resulting in translocated bacteria and leaked gut-derived products, which can reach the liver through the portal vein and might lead to increased oxidative stress and inflammation, thereby threatening liver health. Targeting gut microbiota modulation represents a promising strategy for hepatoprotection. Many natural products could protect the liver from various injuries or mitigate hepatic disorders by reverting gut dysbiosis, improving intestinal permeability, altering the primary bile acid, and inhibiting hepatic fatty acid accumulation. The mechanisms underlying their beneficial effects also include reducing oxidative stress, suppressing inflammation, attenuating fibrosis, and decreasing apoptosis. This review discusses the hepatoprotective effects of dietary natural products via modulating the gut microbiota, mainly focusing on the mechanisms of action.

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Section: Introductionmentioning

confidence: 99%

Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

Meng

et al. 2018

Nutrients

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“…It is reported that these wastes contain a variety of phytochemicals, especially phenols and flavonoids like anthocyanins, resveratrol, tannin and quercetin [ 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. These bioactive components possess various outstanding bioactivities, such as antibacterial, anticancer, antioxidant, anti-inflammation and hepatic and cardiovascular protection effects [ 9 , 10 , 11 , 12 , 13 ], and have great safety and effectiveness advantages in preventing chronic diseases [ 14 , 15 , 16 , 17 ]. They can be used as raw materials to produce functional foods, food additives and pharmaceuticals [ 18 , 19 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Potential of Grape Wastes as a Natural Source of Bioactive Compounds

et al. 2018

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Grapes are widely used in the wine and juice industries, which can lead to massive amounts of waste, mostly grape peels and seeds. The antioxidant capacities, total phenolic and flavonoid contents and phenolic profiles of peels and seeds from 30 grape varieties were systemically assessed. The antioxidant activities of fat-soluble, water-soluble and insoluble-bound fractions of grape peels and seeds were evaluated using ferric-reducing antioxidant power and Trolox equivalent antioxidant capacity assays, and their total phenolic contents and total flavonoid contents were determined by the Folin-Ciocalteu method and AlCl3 colorimetry, respectively. It was found that the antioxidant capacities were diverse among different grape peels and seeds. Moreover, several phenolic compounds were identified and quantified, including gallic acid, cyanidin-3-glucoside, epicatechin, catechin gallate, ferulaic acid, rutin and resveratrol, which could contribute to the antioxidant capacities of these grape peels and seeds. Several grape wastes with strong antioxidant activity could be abundant sources of natural bioactive compounds, and have the potential for development into functional foods, food additives and pharmaceuticals.

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“…Some natural products have been found to protect against liver injuries [166][167][168][169][170]. Tea has also shown a beneficial effect on diet-and chemical-induced disorders in liver, including hepatic oxidative stress damage, inflammation, steatosis, and fibrosis [41,171,172].…”

Section: Hepato-protective Effectmentioning

confidence: 99%

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

Tang

Meng

Gan

et al. 2019

IJMS

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212

135

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Tea is widely consumed all over the world. Generally, tea is divided into six categories: White, green, yellow, oolong, black, and dark teas, based on the fermentation degree. Tea contains abundant phytochemicals, such as polyphenols, pigments, polysaccharides, alkaloids, free amino acids, and saponins. However, the bioavailability of tea phytochemicals is relatively low. Thus, some novel technologies like nanotechnology have been developed to improve the bioavailability of tea bioactive components and consequently enhance the bioactivity. So far, many studies have demonstrated that tea shows various health functions, such as antioxidant, anti-inflammatory, immuno-regulatory, anticancer, cardiovascular-protective, anti-diabetic, anti-obesity, and hepato-protective effects. Moreover, it is also considered that drinking tea is safe to humans, since reports about the severe adverse effects of tea consumption are rare. In order to provide a better understanding of tea and its health potential, this review summarizes and discusses recent literature on the bioactive components, bioavailability, health functions, and safety issues of tea, with special attention paid to the related molecular mechanisms of tea health functions.

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Natural Products for Prevention and Treatment of Chemical‐Induced Liver Injuries

Cited by 71 publications

References 237 publications

Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

Potential of Grape Wastes as a Natural Source of Bioactive Compounds

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

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